基因名：

FARSA

产品别名９�p style="text-indent: 2em;">CML33� FARSL� FARSLA� FRSA� PheHA� RILDBC2� FARSA� phenylalanyl-tRNA synthetase subunit alpha� phenylalanyl-tRNA synthetase subunit alpha� phenylalanine--tRNA ligase alpha subunit� pheRS� phenylalanine tRNA ligase 1, alpha, cytoplasmic� phenylalanine--tRNA ligase alpha chain� phenylalanine-tRNA synthetase alpha-subunit� phenylalanine-tRNA synthetase-like, alpha subunit� phenylalanyl-tRNA synthetase alpha chain� phenylalanyl-tRNA synthetase alpha subunit� phenylalanyl-tRNA synthetase-like, alpha subunit� 慢性粒细胞白血�?3� 苯丙氨酰tRNA合成酶�?FARSa)�

背景信息９�div style="text-indent: 2em;">Aminoacyl-tRNA synthetases consist of a family of enzymes that catalyze the specific aminoacylation of tRNA by their cognate amino acid in the initial step of ribosome-dependent protein biosynthesis. FARSLA, also known as FRSA, CML33, FARSL or PheHA (phenylalanyl-tRNA synthetase, alpha subunit), is a member of the class-II aminoacyl-tRNA synthetase family and is highly expressed in proliferating cells of bone marrow. FARSLA is a cytoplasmic phenylalanine-tRNA synthetase that functions as a heterodimer consisting of a catalytic alpha-subunit and a regulatory beta-subunit. The alpha-subunit is responsible for forming the amino acid binding pocket, mediating the ATP/aminoacyl adenylate binding, and interacts with the acceptor stem of the tRNA. FARSLA functions in a cell cycle-dependent and differentiation-dependent manner.