靶标９�p style="text-indent: 2em;">SMG7

产品别名９�p style="text-indent: 2em;">C1orf16� EST1C� SGA56M� SMG7� SMG7 nonsense mediated mRNA decay factor� SMG7 nonsense mediated mRNA decay factor� nonsense-mediated mRNA decay factor SMG7� EST1 telomerase component homolog C� EST1-like protein C� breast cancer-associated antigen SGA-56M� ever shorter telomeres 1C� smg-7 homolog, nonsense mediated mRNA decay factor�

背景信息９�div style="text-indent: 2em;">SMG7, nonsense mediated mRNA decay factor(SMG7) Homo sapiens This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011],