靶标９�p style="text-indent: 2em;">LDLRAD4

产品别名９�p style="text-indent: 2em;">C18orf1� LDLRAD4� low density lipoprotein receptor class A domain containing 4� low density lipoprotein receptor class A domain containing 4� low-density lipoprotein receptor class A domain-containing protein 4� clone 22� 18号染色体开放阅读框1�

背景信息９�div style="text-indent: 2em;">Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9 SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.