基因名：

GRIN3B

产品别名９�p style="text-indent: 2em;">GluN3B� NR3B� GRIN3B� glutamate ionotropic receptor NMDA type subunit 3B� glutamate ionotropic receptor NMDA type subunit 3B� glutamate receptor ionotropic, NMDA 3B� N-methyl-D-aspartate receptor subtype 3B� NMDA receptor subunit 3B� NMDA type glutamate receptor subunit NR3B� NMDAR3B� glutamate [NMDA] receptor subunit 3B� glutamate receptor, ionotropic, N-methyl-D-aspartate 3B� N-甲基-D-天氡氨酸离子能谷氨酸受体3B(GRIN3B)� 谷氨酸受�?A� 谷氨酸受�?B�

背景信息９�div style="text-indent: 2em;">Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neuro-degeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to 7. The kainate/AMPA receptors are primarily responsible for fast excitatory neurotransmission by glutamate, whereas the NMDA receptors exhibit slow kinesis of Ca2+ ions and a high permeability for Ca2+ ions. One such NMDA receptor, NR3B, is expressed in motor neurons and forms cation channels impermeable to calcium, which can resist many open-channel blockers. NR3B functions in the brain as an excitatory glycine receptor, modifying the normal role of glycine as an inhibitory neurotransmitter.