基因名：

DAGLA

产品别名９�p style="text-indent: 2em;">C11orf11� DAGL(ALPHA)� DAGLALPHA� NSDDR� DAGLA� diacylglycerol lipase alpha� diacylglycerol lipase alpha� diacylglycerol lipase-alpha� DAGL-alpha� DGL-alpha� neural stem cell-derived dendrite regulator� sn1-specific diacylglycerol lipase alpha� 神经干细胞树突调节蛋白DAGLα�

背景信息９�div style="text-indent: 2em;">Members of the AB hydrolase superfamily have diverse catalytic functions and play a crucial role in the metabolism of lipids. DAGLAlpha (diacylglycerol lipase alpha), also known as NSDDR or C11orf11, is a 1,042 amino acid multi-pass membrane protein that belongs to the AB hydrolase superfamily. Highly expressed in brain and pancreas, DAGL?uses calcium as a cofactor to catalyze the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), a reaction that is required for axonal growth and for retrograde synaptic signaling at mature synapses. DAGLAlpha functions as at optimal pH of 7 and its activity is inhibited by p-hydroxy-mercuri-benzoate and HgCl2. The gene encoding DAGLAlpha maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.