产品说明
应用
Fmoc-L-photo-methionine is a diazirine-containing, Fmoc-protected methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907375.
其他说明
Developing diazirine-based chemical probes to identify histone modification ′readers′ and ′erasers ′
Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe
Covalent Capture of Phospho-Dependent Protein Oligomerization by Site-Specific Incorporation of a Diazirine Photo-Cross-Linker
Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)
基本信息
| 经验(实验)分子式 | C21H21N3O4 |
| 分子量 | 379.41 |
产品性质
| 测定 | ≥95% |
| 形式 | powder |
| reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
| application(s) | peptide synthesis |
| 官能团 | Fmoc |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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