CAS 944261-79-4; 5-(4-氯苯基)-n-(3,5-二甲氧基苯基)呋喃-2-甲酰胺; a-803467

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CAS:

944261-79-4

分子式:

C₁₉H₁₆ClNO₄

分子量:

357.79

熔点:

128-130˚C

中文名称:

5-(4-氯苯基)-n-(3,5-二甲氧基苯基)呋喃-2-甲酰胺

英文名称:

a-803467

5-4(-chlorophenyl)-n-(3,5-dimethoxyphenyl)furan-2-carboxamide

性质描述:

可溶解于DMSO, Ethanol

用途:

A 803467是Nav1.8钠离子通道阻断剂，IC50为8 nM，比对Nav1.2，1.3，1.5和1.7的抑制性高100倍。

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货号

品牌

产品名称

规格

包装、参考价格

A796367

MACKLIN

5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺

10mM in DMSO

243元/1ml;

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储存：-20°C

A860969

MACKLIN

5-(4-氯苯基)-N-(3,5-二甲氧基苯基)-2-呋喃甲酰胺

>98%

334元/10mg; 1273元/50mg;

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储存：-20℃
状态：白色到棕褐色粉末
物化性质：可溶解于DMSO, Ethanol
折射率：white solid

A3109

Sigma-Aldrich

A-803467

≥98% (HPLC)

2054.54元/10 MG; 6592.33元/50 MG;

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产品说明

一般描述

小分子A-803467是一种有效的选择性Nav1.8钠离子通道阻滞剂。Nav1.8是一种抗河豚毒素(TTX-R)钠离子通道，通过在周围感觉神经元中传递疼痛刺激而产生痛觉；A-803467通过阻滞该通道，能够对多种模型产生不同程度的疼痛减轻作用。 A-803467已被用于进一步探究Nav1.8在传递疼痛刺激中的作用，也可用作镇痛药。
A-803467能够抑制感觉神经元的自发和诱发动作电位。它具有镇痛作用。A-803467能够在体内减少脊髓背角神经元的放电。

包装

10, 50 mg in glass bottle

生化/生理作用

A-803467能够在半数最大无活性和静止状态下阻断Nav1.8，IC₅₀分别为 8 nM和79 nM。A-803467对Nav1.8的选择性比人类Nav1.2、1.3、1.5和1.7高100倍。

特点和优势

该化合物由Abbott开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

基本信息

经验(实验)分子式	C₁₉H₁₆NO₄Cl
分子量	357.79
MDL编号	MFCD10574689
PubChem化学物质编号	329770815
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to tan
溶解性	DMSO: >10 mg/mL
创始人	Abbott
储存温度	room temp
SMILES string	COc1cc(NC(=O)c2ccc(o2)-c3ccc(Cl)cc3)cc(OC)c1
InChI	1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
InChI key	VHKBTPQDHDSBSP-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

047219

Fluorochem

A803467

98%

8558元/50mg; 32054元/250mg;

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基本信息

CAS Number	944261-79-4
MDL Number	MFCD10574689

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .

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