CAS 919973-83-4; of-1 - �뵺�羺�ٷ��ַ

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货号

品牌

产品名称

规格

包装、参考价格

O797360

MACKLIN

OF-1

10mM in DMSO

648元/1ml;

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储存：-20°C

O872728

MACKLIN

OF-1

99%

680元/5mg;

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储存：-20℃
状态：粉末

1831382

J&K

OF-1

98%, 是BRPF1B和BRPF2 bromodomain抑制剂

808元/5MG; 1283元/10MG;

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基本信息

分子式	C₁₇H₁₈BrN₃O₄S
分子量	440.31
存储条件	Freezer -20℃

产品描述

OF-1是一种有效的 BRPF1B和BRPF2 bromodomain抑制剂，Kd分别为100 nM 和 500 nM。

靶点（IC50 & Targe）

BRPF1B,100nM(Kd)

BRPF2,500nM(Kd)

体外研究

作为BRPF溴结构域的化学探针，OF-1在1μM浓度下增加全长BRPF1B细胞热转移试验中的热稳定性，在5μM浓度下加速BRPF2 FRAP试验中FRAP恢复。此外，OF-1表现出适度的常规细胞毒性。[1]

参考文献

[1] Structural Genomics Consortium (SGC).

安全信息

图形或危害标志
提示语	Warning
危险说明	H302 H410
防范说明	P264 P270 P273 P301+P312 P330 P391 P501
UN号码	3077
危险分类	9
包装等级	III

SML1184

Sigma-Aldrich

OF-1

≥98% (HPLC)

1399.43元/5 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. OF-1 binds to BRPF1B with a K_d of 100 nM , to BRPF2 with a K_d of 500 nM and to BRPF3 with a K_d of 2.4 mM, and shows >100-fold selectivity against most other bromodomains. The closest off-target effects are against BRD4 (39-fold selectivity) and 50% inhibition of TIF1a at 20 μM. For full characterization details, please see OF-1 on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

OF-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₁₇H₁₈BrN₃O₄S
分子量	440.31
MDL编号	MFCD26964046
PubChem化学物质编号	329825706
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	BrC1=CC(C)=C(S(NC(C(OC)=C2)=CC(N3C)=C2N(C)C3=O)(=O)=O)C=C1
InChI	1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
InChI key	YUNQZQREIHWDQT-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H319
预防措施声明	P301 + P310 + P330 - P305 + P351 + P338
危险分类	Acute Tox. 3 Oral - Eye Irrit. 2
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable