CAS 896705-16-1; bmh-21 - �뵺�羺�ٷ��ַ

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CAS:

896705-16-1

分子式:

C₂₁H₂₀N₄O₂

分子量:

360.41

英文名称:

bmh-21

n-[2-(dimethylamino)ethyl]-12-oxo-2h-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide

用途:

BMH-21是一新型DNA嵌入剂(DNA intercalator)，能结合rDNA并抑制RNA polymerase I的转录，不使组蛋白H2AX磷酸化。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

B798208

MACKLIN

BMH-21

10mM in DMSO

546元/1ml;

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储存：-20°C

B860982

MACKLIN

BMH-21

>98%

179元/10mg; 403元/50mg; 623元/100mg;

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储存：-20℃
状态：固体
折射率：light yellow solid

SML1183

Sigma-Aldrich

BMH-21

≥98% (HPLC)

1117.23元/5 MG; 4498.97元/25 MG;

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产品说明

一般描述

BMH-21 is a planar heterocyclic small molecule DNA intercalator.

应用

BMH-21 has been used in cell culture.

包装

5, 25 mg in glass bottle

生化/生理作用

BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines.
BMH-21 has the ability to bind ribosomal DNA and prevent RNA polymerase I (Pol I) transcription and results in the disintegration of the nucleolus. It does not impair DNA damage detection. BMH-21 is considered as an important activator of the p53 pathway.

基本信息

经验(实验)分子式	C₂₁H₂₀N₄O₂
分子量	360.41
MDL编号	MFCD27225377
PubChem化学物质编号	329825705
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	faint yellow to dark orange
溶解性	DMSO: 1 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	O=C(N(C=CC=C1C(NCCN(C)C)=O)C1=N2)C(C2=C3)=CC4=C3C=CC=C4
InChI	1S/C21H20N4O2/c1-24(2)11-9-22-20(26)16-8-5-10-25-19(16)23-18-13-15-7-4-3-6-14(15)12-17(18)21(25)27/h3-8,10,12-13H,9,11H2,1-2H3,(H,22,26)
InChI key	BXYDVWIAGDJBEC-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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