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CAS: 828934-41-4
分子式: C15H18ClO4·Na
分子量: 320.74
中文名称: 
(+)-依托莫西 钠盐 水合物
r(+)-2-[6-(4-氯苯氧基)己基]-环氧乙烷-2-羧酸 钠盐 水合物
英文名称: 
(+)-etomoxir sodium salt hydrate
r(+)-2-[6-(4-chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt hydrate
用途: Etomoxir是不可逆的肉碱棕榈酰基转换酶(CPT-1)的抑制剂,肉碱棕榈酰基转换酶位于线粒体内膜的外侧。Etomoxir还是PPARα的直接激动剂。Etomoxir与CPT-1的催化部位不可逆地结合。抑制CPT-1活性,上调脂肪酸氧化酶活性。Etomoxir对转录的影响可归因于1.能量代谢的变化,增加葡萄糖的利用;2. PPARα的激活[1]。Etomoxir减少MOG特异性T细胞的促炎性细胞因子的产生并促进其凋亡[2]。Etomoxir在小儿胶质母细胞瘤细胞系SF188中减少其耗氧率和ATP、NADPH生成[3]。
推荐供应商
货号品牌产品名称规格包装、参考价格
E792982MACKLINEtomoxir (Na salt)10mM in DMSO707元/1ml;   咨询
储存:-20°C
E872869MACKLINEtomoxir (Na salt)99%394元/5mg;   991元/25mg;   2725元/100mg;   咨询
储存:-20℃
状态:白色到淡-黄色粉末或晶体
236020Sigma-AldrichEtomoxir-CAS 828934-41-4-CalbiochemA cell-permeable, irreversible, and stereospecific compound that is shown to inhibit carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells.3945.15元/5 MG;   咨询

产品说明

警告

Toxicity: Toxic (F)

其他说明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C15H18ClO4 · Na · H2O
分子量338.76

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 50 mg/mL
运输wet ice
储存温度2-8℃

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P264 - P270 - P301 + P310 - P405 - P501
危险分类Acute Tox. 3 Oral
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
E1905Sigma-Aldrich(+)-Etomoxir sodium salt hydrate≥98% (HPLC), powder2490.59元/5 MG;   8553.69元/25 MG;   咨询

产品说明

一般描述

(+)-依托莫西钠盐水合物属于环氧乙烷羧酸基团化合物,调节脂肪酸前体代谢通道。它有利于T细胞氧化压力并且防止T细胞分化。它能抑制脂肪酸代谢,促使饥饿和食物摄入。依托莫西削弱髓源抑制性细胞介导的肿瘤,可能具有治疗潜在价值。

应用

(+)-依托莫西钠盐水合物可用作乳腺肿瘤细胞系和小鼠肿瘤肉毒碱棕榈酰转移酶1(CTP-1)的抑制剂。它还可以用于人原发性前列腺上皮细胞和淋巴细胞的脂肪酸氧化抑制物。

包装

5, 25 mg in glass bottle
气密保存,隔绝光照

生化/生理作用

不可逆O—肉毒碱棕榈酰转移酶1(CTP-1)抑制剂;PPARα 激活剂

基本信息

经验(实验)分子式C15H18ClO4 · Na · H2O
分子量338.76
MDL编号MFCD11044452
PubChem化学物质编号24724474
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white
溶解性H2O: freely soluble
储存温度2-8℃
SMILES stringO.[Na+].[O-]C(=O)[C@@]2(CCCCCCOc1ccc(Cl)cc1)CO2
InChI1S/C15H19ClO4.Na.H2O/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;;/h5-8H,1-4,9-11H2,(H,17,18);;1H2/q;+1;/p-1/t15-;;/m1../s1
InChI keyWENJLJJSJDAJDN-QCUBGVIVSA-M

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P264 - P270 - P301 + P310 + P330 - P405 - P501
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
516300FluorochemSodium (R)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate95+%14762元/250mg;   36960元/1g;   咨询

基本信息

CAS Number828934-41-4
MDL NumberMFCD07787411

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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