产品说明

一般描述

Mouse complement C5a is a 77-amino acid peptide generated during complement activation from the α-chain of complement C5. Mouse C5a shares 60% and 82% amino acid sequence identity to human and rat C5a, respectively. The 9 kDa mouse C5a protein expressed in E. coli contains a N-terminal His-Tag sequence.

生化/生理作用

C5a binds to a signaling G-protein coupled receptor (GPCR) (C5aR/CD88), inducing neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells.

外形

Sterile filtered and Lyophilized without additives.

重悬

Reconstitute to a concentration of 1.0 mg/mL in ice-cold water containing 2.5 mg/mL BSA. The solution should be aliquoted and immediately stored at -70℃.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

基本信息

产品性质

安全信息