CAS 79794-75-5; 氯雷他定; loratadine - �뵺�羺�ٷ��ַ

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

767188

MACKLIN

氯雷他定标准溶液

100μg/mL in Methanol

510元/1ml;

咨询

储存：2-8°C, 避光

L838244

MACKLIN

氯雷他定

> 98 % HPLC, powder

29元/100mg; 36元/500mg; 45元/1g; 62元/5g; 205元/25g; 801元/100g;

咨询

储存：4°C
状态：白色到灰白色固体

L793860

MACKLIN

氯雷他定

10mM in DMSO

362元/1ml;

咨询

储存：-20°C

L0223

TCI

Loratadine

>98.0%(T)(HPLC)

475元/100MG; 1265元/1G;

咨询

基本信息

纯度/分析方法	>98.0%(T)(HPLC)
分子式/分子量	C₂₂H₂₃ClN₂O₂ = 382.89
外观与形状(20℃)	固体
包装和容器	100MG-带有塑料内管的玻璃瓶 (查看图片)
Reaxys-RN	4273483
PubChem物质ID	87560956
Merck Index (14)	5578
MDL编号	MFCD00672869

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(Nonaqueous Titration)	min. 98.0 %
Melting point	135.0 to 139.0 ℃

物性(参考值)

熔点

137 ℃

相关法规

RTECS#

TM6129200

338442

J&K

Loratadine

98%, 一种高效选择性的H1受体拮抗剂

60元/100mg; 131元/1g;

咨询

基本信息

分子式	C₂₂H₂₃ClN₂O₂
分子量	382.88
熔点	137
MDL编码	MFCD00871949
Beilstein	4273483
Merck	14,5578
存储条件	Freezer -20℃

产品描述

Loratadine是一种选择性的histamine H1 receptor拮抗剂，用于治疗过敏。同时还是一种选择性的B(0)AT2抑制剂，其IC50为 4 μM。

靶点（IC50 & Targe）

B(0)AT2,4μM

体外研究

Loratadine被确定为B(0)AT 2的选择性抑制剂，IC 50为4 μM，对SLC6家族的几个其它成员低活性或无活性。[1] 在Der p 1和或抗Fc小量RI预培养的人Fc小量的RI+细胞，Loratadine浓度依赖性抑制组胺和白三烯C4的释放。在抗Fc小量RI激活的纯化HLMC中，Loratadine（0.1 mM）也抑制组胺，白三烯C4和PGD2的释放。在抗Fc小量RI刺激的纯化HSMC中，Loratadine浓度依赖性抑制组胺，类胰蛋白酶，LTC4和PGD 2的释放。[1] 在人脐静脉内皮细胞，Loratadine显著抑制组胺诱导的IL-6和IL-8的分泌。[3] 在转染了hKv1.5通道基因的人Ltk-细胞中，Loratadineh在浓度高于治疗性血浆水平时以浓度，电压，时间和使用依赖性的方式阻断Kv1.5通道。[4]在主支气管或转化（A549）呼吸道上皮细胞中，Loratadineh抑制rhinovirus诱导的ICAM-1的上调。Loratadineh也以剂量依赖的方式抑制鼻病毒感染诱导的ICAM-1的mRNA，并且它们完全抑制鼻病毒诱导的ICAM-1启动子的活化。[5]

参考文献

[1] Cuboni S, et al. J Med Chem, 2014, 57(22), 9473-9479.

[2] Genovese A, et al. Clin Exp Allergy, 1997, 27(5), 559-567.

[3] Molet S, et al. Clin Exp Allergy, 1997, 27(10), 1167-1174.

[4] Delp髇 E, et al. Cardiovasc Res, 1997, 35(2), 341-350.

[5] Papi A, et al. J Allergy Clin Immunol, 2001, 108(2), 221-228.

安全信息

图形或危害标志
提示语	Warning
危险说明	H317 H319
防范说明	P280 P305+P351+P338
UN号码	3077
危险分类	9
包装等级	III
WGK	2
RTECS	TM6129200

PHR1376

Supelco

Loratadine

Pharmaceutical Secondary Standard; Certified Reference Material

1669.88元/1 G;

咨询

产品说明

一般描述

Loratadine belongs to the class of H1-antihistamine drugs, with non-sedating properties, and is widely used in the treatment of allergies.

应用

Loratadine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

非镇静组胺H₁-受体拮抗剂。

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3785 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式	C₂₂H₂₃N₂O₂Cl
分子量	382.88
MDL编号	MFCD00672869
PubChem化学物质编号	329823353
NACRES	NA.24

产品性质

质量水平	300
等级	certified reference material pharmaceutical secondary standard
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable gas chromatography (GC): suitable
application(s)	pharmaceutical (small molecule)
格式	neat
药典可追溯性	traceable to BP 874 traceable to PhEur Y0000688 traceable to USP 1370270
储存温度	2-30℃
SMILES string	CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
InChI	1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI key	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Gene Information	human ... HRH1(3269)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0000688

Loratadine

European Pharmacopoeia (EP) Reference Standard

1277.32元/ ;

咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

非镇静组胺H₁-受体拮抗剂。

包装

Unit quantity: 60 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₂H₂₃N₂O₂Cl
分子量	382.88
MDL编号	MFCD00672869
PubChem化学物质编号	329831098
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
InChI	1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI key	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Gene Information	human ... HRH1(3269)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

Y0000603

Loratadine for system suitability

European Pharmacopoeia (EP) Reference Standard

1572.27元/ ;

咨询

产品说明

一般描述

生化/生理作用

非镇静组胺H₁-受体拮抗剂。

包装

Unit quantity: 15 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₂H₂₃N₂O₂Cl
分子量	382.88
MDL编号	MFCD00672869
PubChem化学物质编号	329831044
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	EDQM
application(s)	pharmaceutical (small molecule)
格式	neat
储存温度	2-8℃
SMILES string	CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
InChI	1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI key	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Gene Information	human ... HRH1(3269)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

L9664

Sigma-Aldrich

Loratadine

≥98% (HPLC), powder

2297.06元/10 MG; 6337.89元/50 MG;

咨询

产品说明

生化/生理作用

氯雷他定是一种非镇静性组胺H1受体拮抗剂。其可抑制双孔结构域钾通道K2P18.1(也称为TRESK或KCNK18)。
非镇静组胺H₁-受体拮抗剂。

特点和优势

该化合物由Schering Plough开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

其他说明

斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDF L9664.pdf 中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息，请访问sigma.com/metlin。

基本信息

经验(实验)分子式	C₂₂H₂₃N₂O₂Cl
分子量	382.88
MDL编号	MFCD00672869
PubChem化学物质编号	24278525
NACRES	NA.77

产品性质

质量水平	200
测定	≥98% (HPLC)
形式	powder
颜色	white
溶解性	DMSO: soluble 50 mg/mL H₂O: insoluble
创始人	Schering Plough
储存温度	2-8℃
SMILES string	CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
InChI	1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI key	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Gene Information	human ... CYP3A4(1576), HRH1(3269), KCNH1(3756), KCNH2(3757), PTAFR(5724) rat ... Hrh1(24448)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

1370270

USP

Loratadine

United States Pharmacopeia (USP) Reference Standard

5402.06元/200 MG;

咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

非镇静组胺H₁-受体拮抗剂。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₂H₂₃N₂O₂Cl
分子量	382.88
MDL编号	MFCD00672869
PubChem化学物质编号	329750256
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
InChI	1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI key	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Gene Information	human ... HRH1(3269)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

BP874

Loratadine

British Pharmacopoeia (BP) Reference Standard

2189.77元/100 MG;

咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

非镇静组胺H₁-受体拮抗剂。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₂H₂₃N₂O₂Cl
分子量	382.88
MDL编号	MFCD00672869
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
InChI	1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI key	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Gene Information	human ... HRH1(3269)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable

BP875

Loratadine impurity standard

British Pharmacopoeia (BP) Reference Standard

1916.08元/25 MG;

咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

非镇静组胺H₁-受体拮抗剂。

包装

Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₂H₂₃N₂O₂Cl
分子量	382.88
MDL编号	MFCD00672869

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	mixture
储存温度	2-8℃
SMILES string	CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
InChI	1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI key	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Gene Information	human ... HRH1(3269)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable