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关键词:       仅模糊查询
CAS: 79559-97-0
分子式: C17H18Cl3N
分子量: 342.69
中文名称: 
盐酸舍曲林
英文名称: 
4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphthalenamin hydroch
(1S-cis)-lorid
sertraline hydrochloride
setraline hcl
Sertraline HCl
Sertraline HCI
用途: 抗抑郁药。
推荐供应商
货号品牌产品名称规格包装、参考价格
S838258MACKLIN(1S,4S)-4-(3,4-二氯苯基)-N-甲基-1,2,3,4-四氢萘-1-胺 盐酸盐solid, 98%(HPLC)59元/250mg;   91元/1g;   252元/5g;   1042元/25g;   3008元/100g;   咨询
储存：室温
状态：白色到灰白色固体
S0507TCISertraline Hydrochloride>98.0%(T)(HPLC)460元/1G;   1530元/5G;   咨询

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C17H17Cl2N・HCl = 342.69
外观与形状(20℃)固体
相关CAS RN79617-96-2
Reaxys-RN5783715
PubChem物质ID87558859
SDBS (AIST Spectral DB)51798
Merck Index (14)8467
MDL编号MFCD00895772

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Nonaqueous Titration)min. 98.0 %
Melting point245.0 to 249.0 ℃
Specific rotation [a]20/D+35.0 to +41.0 deg(C=2,MeOH)

物性(参考值)

熔点245 ℃
比旋光度 [α]D38° (C=2,MeOH)
溶解性(可溶于)甲醇

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。

相关法规

RTECS#QJ0352070
949909J&KSertraline Hydrochloride98%, 一种抗抑郁药物, 选择性5-羟色胺再吸收抑制剂(SSRI)385元/1G;   1922元/5G;   咨询

基本信息

分子式C17H17Cl2N·HCl
分子量342.69
熔点245-249
比旋光度([α]20D)+38 (C=2, MeOH)
MDL编码MFCD00895772

产品描述

Sertraline HCl是一种5-HT抑制剂， Ki值为13 nM.

靶点（IC50 & Targe）

5-HT,13nM(Ki)

体外研究

Sertraline比fluvoxamine，zimelidine，norzimelidine，fluoxetine 或 chlorimipramine能够更好的选择性抑制5-HT的吸收，而对NE吸收的抑制较弱。然而，Sertraline对阻断5-HT摄取与DA摄取的选择性比这些药剂低。[1]

体内研究

Sertraline HCl (32微摩尔/千克，腹腔注射)抑制超过50%的5-羟色胺吸收到大鼠纹状体突触体。Sertraline HCl逆转PCA 引起的5-羟色胺消耗，比氯丙咪嗪有效6倍，比阿米替林有效60倍。Sertraline急性重复性给药降低全血中5-羟色胺含量。在抗抑郁Porsolt 游泳测试中，Sertraline HCl大大降低小鼠的不动性。对大鼠多次重复给药后，sertraline HCl减少边缘前脑腺苷酸环化酶对去甲肾上腺素的环AMP响应，以及[3H] dihydroalprenolol与皮脂膜的结合。[1]

动物实验

Animal Models: 大鼠，小鼠

Formulation: 在水或混合物（体积百分比），5%乙醇 + 5%乳化剂-EL-620 + 90%生理盐水中。

Dosages: --

Administration: 腹腔注射

(Only for Reference)

参考文献

[1] Koe BK, et al. J Pharmacol Exp Ther, 1983, 226(3), 686-700.

[2] Koe BK. J Pharmacol Exp Ther, 1976, 199(3), 649-661.

安全信息

防范说明P262
WGK3
RTECSQJ0352070
C46219Alfa AesarSertraline Hydrochloride1327元/1g;   5021元/5g;   咨询

基本信息

Ref#
46219

分子式
C17H17Cl2N.HCl

分子量
1346.35

GHS危害和防范说明

GHS符号

Hazard Statements
H302
Harmful if swallowed.

Precautionary Statements
P301+P330+P331 P312 P264

Y0000828Sertraline HydrochlorideEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Sertraline hydrochloride is a SSRI i.e selective serotonin reuptake inhibitor. It is mainly used in treating psychiatric disorders. It also is effective in treating hypotension occurring in disorders like neurocardiogenic syncope and idiopathic orthostatic hypotension which is affected by autonomic dysfunction.

生化/生理作用

选择性 5-羟色胺再摄取抑制剂，抗抑郁药。

包装

Unit quantity: 200 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C17H17NCl2 · HCl
分子量342.69
MDL编号MFCD00895772
PubChem化学物质编号329831175
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
InChI1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI keyBLFQGGGGFNSJKA-XHXSRVRCSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07GHS09
警示用语：Warning
危险声明H302 - H400
预防措施声明P273 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0000866Sertraline for peak identificationEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Sertraline hydrochloride is a SSRI i.e selective serotonin reuptake inhibitor. It is mainly used in treating psychiatric disorders. It also is effective in treating hypotension occurring in disorders like neurocardiogenic syncope and idiopathic orthostatic hypotension which is affected by autonomic dysfunction.

生化/生理作用

选择性 5-羟色胺再摄取抑制剂，抗抑郁药。

包装

Unit quantity: 5.4 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C17H17NCl2 · HCl
分子量342.69
MDL编号MFCD00895772
PubChem化学物质编号329831197
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
InChI1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI keyBLFQGGGGFNSJKA-XHXSRVRCSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07GHS09
警示用语：Warning
危险声明H302 - H400
预防措施声明P273 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0000867Sertraline for system suitabilityEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Sertraline hydrochloride is a SSRI i.e selective serotonin reuptake inhibitor. It is mainly used in treating psychiatric disorders. It also is effective in treating hypotension occurring in disorders like neurocardiogenic syncope and idiopathic orthostatic hypotension which is affected by autonomic dysfunction.

生化/生理作用

选择性 5-羟色胺再摄取抑制剂，抗抑郁药。

包装

Unit quantity: 6.2 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C17H17NCl2 · HCl
分子量342.69
MDL编号MFCD00895772
PubChem化学物质编号329831198
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
InChI1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI keyBLFQGGGGFNSJKA-XHXSRVRCSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07GHS09
警示用语：Warning
危险声明H302 - H400
预防措施声明P273 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
5.06188Sigma-AldrichSertraline Hydrochloride-CAS 79559-97-0-Calbiochem2289.97元/10 MG;   咨询

产品说明

一般描述

A very potent uptake inhibitor highly selective for serotonin (Ki = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.

生化/生理作用

Primary Target
5-HT uptake transporter

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.

Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.
Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.
Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C17H17Cl2N · xHCl
分子量306.23 (free base basis)
MDL编号MFCD00895772

产品性质

质量水平100
测定≥99% (HPLC)
形式solid
效能3.3 nM Ki
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 100 mM
ethanol: 50 mM
储存温度2-8℃
InChI1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI keyBLFQGGGGFNSJKA-XHXSRVRCSA-N

安全信息

象形图GHS07GHS09
警示用语：Warning
危险声明H302 - H400
预防措施声明P264 - P270 - P273 - P301 + P312 - P391 - P501
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
S6319Sigma-AldrichSertraline Hydrochloride≥98% (HPLC)2069.62元/10 MG;   6095.01元/50 MG;   咨询

产品说明

应用

在长期准备好的绵羊胎儿中研究了盐酸舍曲林暴露的影响。将其用于糖皮质激素功能测定，研究抗抑郁药对人体糖皮质激素受体功能的影响。

包装

10, 50 mg in glass bottle

生化/生理作用

舍曲林抑制血小板功能，显示抗血小板和内皮保护功能。缓解抑郁症，提高心血管疾病患者的生活质量。 也可开处方治疗帕金森病的抑郁症状。
选择性 5-羟色胺再摄取抑制剂，抗抑郁药。

特点和优势

该化合物由 Pfizer 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
该化合物出现在受体分类和信号转导手册的生物胺转运蛋白页，如需浏览其他手册页，请点击此处。

基本信息

经验(实验)分子式C17H17NCl2 · HCl
分子量342.69
MDL编号MFCD00895772
PubChem化学物质编号24278601
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D +33 to +43°, c = 2.0 in methanol
颜色 white
溶解性DMSO: >20 mg/mL
创始人Pfizer
SMILES stringClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
InChI1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI keyBLFQGGGGFNSJKA-XHXSRVRCSA-N
Gene Informationhuman ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

安全信息

象形图GHS07GHS09
警示用语：Warning
危险声明H302 - H400
预防措施声明P273 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
PHR2535SupelcoSertraline HydrochloridePharmaceutical Secondary Standard; Certified Reference Material5376.34元/200 MG;   咨询

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

生化/生理作用

选择性 5-羟色胺再摄取抑制剂，抗抑郁药。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

基本信息

经验(实验)分子式C17H17NCl2 · HCl
分子量342.69
MDL编号MFCD00895772

产品性质

等级certified reference material
pharmaceutical secondary standard
形式powder
CofAcurrent certificate can be downloaded
包装pkg of 200 mg
药典可追溯性traceable to BP 833
traceable to PhEur Y0000828
traceable to USP 1312539
储存温度2-8℃
SMILES stringClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
InChI1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI keyBLFQGGGGFNSJKA-XHXSRVRCSA-N

安全信息

象形图GHS07GHS09
警示用语：Warning
危险声明H302 - H400
预防措施声明P273 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP883Sertraline HydrochlorideBritish Pharmacopoeia (BP) Reference Standard2244.51元/100 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

选择性 5-羟色胺再摄取抑制剂，抗抑郁药。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C17H17NCl2 · HCl
分子量342.69
MDL编号MFCD00895772
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
InChI1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI keyBLFQGGGGFNSJKA-XHXSRVRCSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07GHS09
警示用语：Warning
危险声明H302 - H400
预防措施声明P273 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1612539USPSertraline HydrochlorideUnited States Pharmacopeia (USP) Reference Standard8255.51元/100 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Sertraline hydrochloride is a SSRI i.e selective serotonin reuptake inhibitor. It is mainly used in treating psychiatric disorders. It also is effective in treating hypotension occurring in disorders like neurocardiogenic syncope and idiopathic orthostatic hypotension which is affected by autonomic dysfunction.

生化/生理作用

选择性 5-羟色胺再摄取抑制剂，抗抑郁药。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C17H17NCl2 · HCl
分子量342.69
MDL编号MFCD00895772
PubChem化学物质编号329751093
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
InChI1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI keyBLFQGGGGFNSJKA-XHXSRVRCSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07GHS09
警示用语：Warning
危险声明H302 - H400
预防措施声明P273 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP897Sertraline hydrochloride impurity standardBritish Pharmacopoeia (BP) Reference Standard1916.08元/20 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

选择性 5-羟色胺再摄取抑制剂，抗抑郁药。

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C17H17NCl2 · HCl
分子量342.69
MDL编号MFCD00895772

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式mixture
储存温度2-8℃
SMILES stringClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
InChI1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI keyBLFQGGGGFNSJKA-XHXSRVRCSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07GHS09
警示用语：Warning
危险声明H302 - H400
预防措施声明P264 - P270 - P273 - P301 + P312 + P330 - P391 - P501
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9
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