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CAS: 79-33-4
分子式: C3H6O3
分子量: 90.08
沸点: 125℃
熔点: 53 °C
中文名称: 
L-(+)-乳酸
L-无水乳酸
L-2-羟基丙酸
(S)-(+)-2-羟基丙酸
(S)-2-羟基丙酸
2-羟基丙酸
α-羟基丙酸
2-羟基丙酸
英文名称: 
2-hydroxy-, (S)-Propanoic acid
l-lactic aci
(+)-lactic acid
(S)-(+)-lactic acid
(S)-2-hydroxypropanoic acid
(S)-2-hydroxypropionic acid
(S)-lactic acid
d-lactic acid
espiritin
l-(+)-lactic acid
l-lactic acid
paralactic acid
ph 90
purac
sarcolactic acid
tisulac
l(+)-lactic acid
L-(+)-Lactic acid solution
Lactic acid solution
L-Lactic acid,anhydrous
propanoic acid,2-hydroxy-,(S)-
L-2-hydroxypropanoic acid
(+)-Milchsαure
(S)-Milchsαure
L-Milchsαure
Fleisch-Milchsαure
展开更多英文名
推荐供应商
货号品牌产品名称规格包装、参考价格
L812603MACKLINL-乳酸分析对照品, ≥98%155元/100mg;   咨询
储存:2-8°C
状态:白色粉末或晶体
L812673MACKLINL-(+)-乳酸ACS, ≥85%40元/100ml;   101元/500ml;   396元/2.5L;   1399元/10L;   咨询
储存:2~8°C,干燥,密封
状态:无色粘稠液体
L794459MACKLINL-乳酸10mM in DMSO475元/1ml;   咨询
储存:-20°C
状态:液体
L812422MACKLINL-乳酸高纯级,90%66元/100ml;   100元/250ml;   167元/500ml;   637元/2.5L;   2316元/10L;   4532元/25L;   咨询
储存:2~8°C,干燥,密封
状态:无色到浅黄色液体

1. 具有柔和的酸味,酸味持续时间久,是天然的酸味剂; 2. 作为pH调节用的常用有机酸,通常会有强烈的酸味,而L-乳酸酸味温和适中,无不良气味,不会对最终产品的风味产生负面影响,最适宜作为pH调节剂; 3. 具有防腐作用,通过pH调节,可降低病原微生物的生长,延长食品的货架期; 4. 为弱挥发性液态有机酸,浓度变化小,不易蒸发,便于使用

L812421MACKLINL-乳酸耐热级,88%100元/500ml;   356元/2.5kg;   1139元/10kg;   咨询
储存:2~8°C,干燥,密封
状态:无色粘稠液体
L812604MACKLINL-乳酸98%202元/1g;   559元/5g;   2283元/25g;   咨询
储存:2~8°C,干燥,密封
L812674MACKLINL-(+)-乳酸手性级,90%41元/100ml;   130元/500ml;   569元/2.5L;   2016元/10L;   咨询
储存:2~8°C,干燥,密封
状态:无色到黄色液体

1. 具有柔和的酸味,酸味持续时间久,是天然的酸味剂; 2. 作为pH调节用的常用有机酸,通常会有强烈的酸味,而L-乳酸酸味温和适中,无不良气味,不会对最终产品的风味产生负面影响,最适宜作为pH调节剂; 3. 具有防腐作用,通过pH调节,可降低病原微生物的生长,延长食品的货架期; 4. 为弱挥发性液态有机酸,浓度变化小,不易蒸发,便于使用

L0165TCIL-Lactic Acid>85.0%(T)235元/25G;   590元/500G;   咨询

基本信息

纯度/分析方法>85.0%(T)
分子式/分子量C3H6O3 = 90.08
外观与形状(20℃)液体
储存在惰性气体下存放于惰性气体之中
应避免的情况湿气 (吸湿)
Reaxys-RN1720251
PubChem物质ID87572116
Merck Index (14)5337
MDL编号MFCD00064266

技术规格

AppearanceColorless to Almost colorless clear liquid
Purity(Neutralization back titration)min. 85.0 %
Specific rotation [a]20/D-10.0 to -15.0 deg(C=2.5, 1.5mol/L NaOH sol.)

物性(参考值)

比重1.21
比旋光度 [α]D-13° (C=2.5,1.5mol/L NaOH sol.)
折射率1.43
水溶性可溶
溶解性(可溶于)醇,丙酮
溶解性(不溶于)氯仿

安全信息

图形或危害标志
信号词危险
危险性说明H303 : 吞咽可能有害。
H314 : 造成严重皮肤灼伤和眼损伤。
H290 : 可能腐蚀金属。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P234 : 只能在原容器中存放。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P390 : 吸收溢出物,防止材料损坏。
P312 : 如感觉不适,呼叫急救中心/医生。
P303 + P361 + P353 : 如皮肤(或头发)沾染:立即脱掉所有沾污的衣物。用水清洗皮肤/淋浴。
P301 + P330 + P331 : 如误吞咽:漱口。不要诱导呕吐。
P363 : 沾染的衣服清洗后方可重新使用。
P304 + P340 + P310 : 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。立即呼叫急救中心/医生。
P305 + P351 + P338 + P310 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。立即呼叫急救中心/医生。
P406 : 贮存于抗腐蚀/带抗腐蚀衬里的容器中。
P405 : 存放处须加锁。

相关法规

RTECS#OD3100000

运输信息

UN编号UN3265
类别8
包装类别 III
监管条件代码(*)
148977J&KL-(+)-Lactic acid90%134元/100ML;   328元/500ML;   1576元/2.5L;   咨询

基本信息

分子式C3H6O3
分子量90.08
沸点125
闪点110
密度1.2
折光率(n20D)1.4260-1.4280
比旋光度([α]20D)-15.0 to -10.0° (C=2.5, 1.5 mol/L NaOH)
MDL编码MFCD00064266
Beilstein1720251
Merck14,5337
EINECS 编号201-196-2
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H315
H318
防范说明P280
P305+P351+P338
P310
WGK1
RTECSOD2800000
A17268Alfa AesarL-(+)-Lactic acidca 85-90% aq. soln.431元/100g;   1000元/500g;   3769元/2500g;   咨询

应用
It is most commonly used for fluid resuscitation after blood loss due to trauma, surgery, or burn injury. It is used in the agricultural, chemical, leather processing, pharmaceuticals, and cosmetics industries, used as an electroplating agent, food/feed additive, pH regulator, cleaning/washing agent, and tanning agent; used to flavor animal feeds; used as a solvent and intermediate in chemical production, as a pH regulator in fabric finishing, and in paints, coatings, soaps, and cleaning products; used to make large scale and fine chemicals, pulp-paper-paper products, food products, and plastic products, in mining, health services, agriculture-forestry-fishing, and building and construction work.

备注
Store away from strong bases and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

基本信息

MDL
MFCD00064266

EINECS
201-196-2

分子式
C3H6O3

分子量
90.08

熔点
18°

闪点
>110°(230°F)

密度
1.209

折射率
1.4270

灵敏度
Ambient temperatures.

形态
Liquid

溶解性
Fully miscible in water. Soluble in water.

Beilstein
1720251

Merck
14,5337

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H318
Causes skin irritation.Causes serious eye damage.

Precautionary Statements
P280a-P264-P305+P351+P338-P310a-P321-P332+P313
Wear protective gloves and eye/face protection.Wash thoroughly after handling.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Specific treatment (see label).If skin irritation occurs: Get medical advice/attention.

安全信息

危险等级
8

包装组
III

危险类别
38-41
Irritating to skin.Risk of serious damage to eyes.

安全等级
26-37/39
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable gloves and eye/face protection.

RTECS
OD3100000

TSCA

L13242Alfa AesarL-Lactic Acidanhydrous, 98%727元/5g;   2801元/25g;   8162元/100g;   咨询

应用
Useful chiral synthon, building block for depsipeptides.L-Lactic acid is an intermediate in the fermentation of sugar. It plays a vital role in several biochemical processes. It is a major ingredient in processed foods such as yogurt, cottage cheeses, koumiss and kombucha. It gives the sour flavor to sourdough breads. It finds application in pharmaceuticals to prepare water-soluble lactates, topical preparations and cosmetics. It acts as a food preservative, flavoring agent, curing agent, descaler, soap-scum remover and an anti-bacterial agent. It is an active component of lactated Ringer's solution and Hartmann's solution. Further, it is used for fluid resuscitation after blood loss due to trauma and surgery.

备注
Hygroscopic. Store in a cool place. Incompatible with strong bases, strong oxidizing agents, strong reducing agents and metals.

基本信息

MDL
MFCD00064266

EINECS
201-196-2

分子式
C3H6O3

分子量
90.08

熔点
52-54°

沸点
119°/12mm

闪点
>110°(230°F)

密度
1.22

灵敏度
Keep Cold. Hygroscopic. Store under Argon.

形态
Crystalline powder

溶解性
Soluble in water.

Beilstein
1720251

Merck
14,5337

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H318
Causes skin irritation.Causes serious eye damage.

Precautionary Statements
P280b-P305+P351+P338-P337+P313
Wear protective gloves and eye protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.If eye irritation persists: Get medical advice/attention.

安全信息

危险等级
8

包装组
III

危险类别
38-41
Irritating to skin.Risk of serious damage to eyes.

安全等级
26-37/39-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable gloves and eye/face protection.This material and its container must be disposed of as hazardous waste

RTECS
OD3100000

TSCA

C18987Alfa AesarL(+)-Lactic acid90% solution in water687元/250ml;   1407元/1L;   4886元/5L;   咨询

基本信息

Ref#
18987

MDL
64266

分子式
C3 H6 O3

分子量
90.08

闪点
>112

密度
1.2

形态
Colorless liquid

BP26615Alfa AesarL-(+)-LACTIC ACID FREE 5G1754元/5g;   咨询

基本信息

Ref#
F53173

R40026Alfa AesarLactic acidAR Grade6496元/10mg;   11692元/25mg;   32479元/100mg;   咨询

基本信息

MDL
MFCD00064266

EINECS
201-196-2

分子式
C{3}H{6}O{3}

分子量
90.08

熔点
53°

密度
1.200

形态
White powder

安全信息

危险类别
38-41
Irritating to skin.Risk of serious damage to eyes.

安全等级
26-37/39-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable gloves and eye/face protection.This material and its container must be disposed of as hazardous waste

RTECS
OD3100000

TSCA

27714Sigma-AldrichL-(+)-Lactic acid solutionmeets analytical specification of Ph. Eur., BP, 88-92% total acid basis1085.62元/500 ML;   2062.57元/1 L;   3702.54元/2.5 L;   5093.59元/25 KG;   咨询

产品说明

其他说明

l(+)-乳酸盐水溶液
货号27714-4X2.5L将被停产。请订购物理性质和规格相同的单瓶27714-2.5L。
货号27714-6X1L将被停产。请订购物理性质和规格相同的单瓶27714-1L。

基本信息

经验(实验)分子式C3H6O3
分子量90.08
Beilstein1720251
MDL编号MFCD00064266
PubChem化学物质编号57648268
NACRESNA.21

产品性质

质量水平200
测定88-92% total acid basis
质量meets analytical specification of Ph. Eur., BP
杂质 insoluble in ether, complies
methanol, complies (GC)
residual solvents, complies
sugar and orther red. Substances, complies
≤0.0005% heavy metals (as Pb)
灼烧残渣≤0.05% (as SO4)
溶解性water: soluble(lit.)
痕量阴离子chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg
痕量阳离子Ca: ≤100 mg/kg
Fe: ≤10 mg/kg
适用性complies for appearance of solution
SMILES stringC[C@H](O)C(O)=O
InChI1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
InChI keyJVTAAEKCZFNVCJ-REOHCLBHSA-N

安全信息

象形图GHS05
警示用语:Danger
危险声明H314
预防措施声明P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
危险分类Eye Dam. 1 - Skin Corr. 1C
补充剂危害EUH071
储存分类代码8A - Combustible, corrosive hazardous materials
WGKWGK 1
闪点(F)230.0 °F
闪点(C)110 ℃
个人防护装备Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
L1875Sigma-AldrichL-(+)-Lactic acid solution30% in H2O (by weight)933.3元/100 ML;   1546.36元/250 ML;   4214.81元/1 L;   咨询

产品说明

应用

L-(+)-乳酸溶液可用于制备新型的pH敏感的物理交联水凝胶。可通过直接缩聚反应用于制备低分子量聚乳酸。

包装

100, 250 mL in glass bottle

其他说明

l(+)-乳酸盐水溶液

联系

纯度相当于 L 1750。

基本信息

经验(实验)分子式C3H6O3
分子量90.08
Beilstein1720251
MDL编号MFCD00064266
PubChem化学物质编号24896292
NACRESNA.25

产品性质

质量水平200
浓度30% in H2O (by weight)
溶解性water: soluble(lit.)
储存温度2-8℃
SMILES stringC[C@H](O)C(O)=O
InChI1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
InChI keyJVTAAEKCZFNVCJ-REOHCLBHSA-N

安全信息

象形图GHS05
警示用语:Danger
危险声明H315 - H318
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
危险分类Eye Dam. 1 - Skin Irrit. 2
储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)235.4 °F - closed cup
闪点(C)113 ℃ - closed cup
个人防护装备Eyeshields, Gloves, type ABEK (EN14387) respirator filter
69780Sigma-AldrichL-(+)-Lactic acid solution~40% in H2O1866.23元/250 ML;   5526.9元/1 L;   咨询

产品说明

其他说明

l(+)-乳酸盐水溶液

基本信息

经验(实验)分子式C3H6O3
分子量90.08
Beilstein1720251
MDL编号MFCD00064266
PubChem化学物质编号57652208
NACRESNA.25

产品性质

形式liquid
质量水平100
浓度~40% in H2O
杂质≤1% D-lactic acid
SMILES stringC[C@H](O)C(O)=O
InChI1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
InChI keyJVTAAEKCZFNVCJ-REOHCLBHSA-N

安全信息

象形图GHS05
警示用语:Danger
危险声明H315 - H318
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
危险分类Eye Dam. 1 - Skin Irrit. 2
储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)235.4 °F - closed cup
闪点(C)113 ℃ - closed cup
个人防护装备Eyeshields, Gloves, type ABEK (EN14387) respirator filter
L1750Sigma-AldrichL-(+)-Lactic acid≥98%1595.81元/10 G;   7240.46元/100 G;   咨询

产品说明

一般描述

L-(+)-亚油酸是人类和哺乳动物中唯一天然存在的乳酸。在商业上,少数细菌,如 干酪乳杆菌德氏乳杆菌乳酸链球菌 可通过发酵过程产生 L-乳酸。乳酸激活羟基羧酸受体,G-蛋白偶联受体81(GPR81)。

应用

亚油酸已可用于:

  • 作为乳酸脱氢酶反应的底物溶液II的组分
  • 作为存储溶液A中的添加剂
  • 作为人工胃液制剂的补充物,用于评价 乳酸菌 对胃应激的抵抗程度

包装

10, 100 g in glass bottle

生化/生理作用

L-(+)-亚油酸用作乳酸脱氢酶和乳酸氧化酶的底物。

基本信息

经验(实验)分子式C3H6O3
分子量90.08
Beilstein1720251
EC 号201-196-2
MDL编号MFCD00064266
PubChem化学物质编号24896289
NACRESNA.25

产品性质

质量水平200
测定≥98%
作用机制cell membrane | interferes
抗生素抗菌谱Gram-negative bacteria
储存温度2-8℃
SMILES stringC[C@H](O)C(O)=O
InChI1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
InChI keyJVTAAEKCZFNVCJ-REOHCLBHSA-N

安全信息

象形图GHS05
警示用语:Danger
危险声明H315 - H318
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
危险分类Eye Dam. 1 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)230.0 °F - closed cup
闪点(C)110.00 ℃ - closed cup
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
L6402Sigma-AldrichL-(+)-Lactic acidBioXtra, ≥98% (titration)715.19元/1 G;   2081.44元/5 G;   3593.57元/10 G;   咨询

产品说明

包装

1, 5, 10 g in glass bottle

生化/生理作用

L-(+)-亚油酸用作乳酸脱氢酶和乳酸氧化酶的底物。

基本信息

经验(实验)分子式C3H6O3
分子量90.08
Beilstein1720251
EC 号201-196-2
MDL编号MFCD00064266
PubChem化学物质编号24896436
NACRESNA.25

产品性质

质量水平200
产品线BioXtra
测定≥98% (titration)
杂质≤0.005% Phosphorus (P)
≤0.1% Insoluble matter
灼烧残渣≤0.1%
溶解性H2O: 1 M at 20 ℃, clear, colorless
痕量阴离子chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%
痕量阳离子Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%
抗生素抗菌谱Gram-negative bacteria
作用机制cell membrane | interferes
储存温度2-8℃
SMILES stringC[C@H](O)C(O)=O
InChI1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
InChI keyJVTAAEKCZFNVCJ-REOHCLBHSA-N

安全信息

象形图GHS05
警示用语:Danger
危险声明H315 - H318
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
危险分类Eye Dam. 1 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
V900016Sigma-AldrichL-(+)-Lactic acidVetec, reagent grade, 86%282.73元/100 G;   615.87元/500 G;   咨询

产品说明

包装

100, 500 g in glass bottle

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

经验(实验)分子式C3H6O3
分子量90.08
Beilstein1720251
MDL编号MFCD00064266
PubChem化学物质编号329829448

产品性质

等级reagent grade
产品线Vetec
测定86%
SMILES stringC[C@H](O)C(O)=O
InChI1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
InChI keyJVTAAEKCZFNVCJ-REOHCLBHSA-N

安全信息

象形图GHS05
警示用语:Danger
危险声明H315 - H318
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
危险分类Eye Dam. 1 - Skin Irrit. 2
储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)230.0 °F - closed cup
闪点(C)110 ℃ - closed cup
46937SupelcoL-(+)-Lactic acidanalytical standard1523.9元/100 MG;   咨询

产品说明

应用

有关合适的仪器技术的更多信息,请参阅产品的分析证书。想要获得更多支持,请联系技术服务部。

基本信息

经验(实验)分子式C3H6O3
分子量90.08
Beilstein1720251
EC 号201-196-2
MDL编号MFCD00064266
PubChem化学物质编号24870591

产品性质

质量水平100
等级analytical standard
CofAcurrent certificate can be downloaded
包装ampule of 100 mg
technique(s)HPLC: suitable
gas chromatography (GC): suitable
抗生素抗菌谱Gram-negative bacteria
application(s)cleaning products
cosmetics
food and beverages
personal care
格式neat
作用机制cell membrane | interferes
储存温度−20℃
SMILES stringC[C@H](O)C(O)=O
InChI1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
InChI keyJVTAAEKCZFNVCJ-REOHCLBHSA-N

安全信息

象形图GHS05
警示用语:Danger
危险声明H315 - H318
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
危险分类Eye Dam. 1 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)230.0 °F - closed cup
闪点(C)110.00 ℃ - closed cup
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
BIOC-059N-50MGAccuStandardL-(+)-Lactic acid695元/50mg;   咨询
L-(+)-Lactic acidL-(+)-乳酸79-33-4
094601Fluorochem(2S)-2-Hydroxypropanoic acid90%550元/500g;   1056元/1kg;   4444元/5kg;   咨询

基本信息

CAS Number79-33-4
MDL NumberMFCD00064266
Density1.209

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H318: Causes serious eye damage.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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