CAS 78186-34-2; bis((4,5-dihydro-1h-imidazol-2-yl)hydrazone)-10-anthracenedicarboxaldehyde

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CAS:

78186-34-2

分子式:

C₂₂H₂₂N₈

分子量:

398.46

英文名称:

bis((4,5-dihydro-1h-imidazol-2-yl)hydrazone)-10-anthracenedicarboxaldehyde

bisantrene

用途:

Bisantrene 是一种高效的抗肿瘤药物，靶向作用于真核生物的II型拓扑异构酶 (II topoisomerases)。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

B860568

MACKLIN

比生群

>96%

916元/25mg; 1651元/50mg; 2872元/100mg;

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储存：-20°C

B4563

Sigma-Aldrich

Bisantrene dihydrochloride

≥98% (HPLC)

1046.75元/10 MG; 4148.05元/50 MG;

咨询

产品说明

应用

Bisantrene (NSC 337766), and its derivatives are topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor.

包装

10, 50 mg in glass bottle

生化/生理作用

Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein.
Bisantrene is an anthracene bishydrazone derivative, which has antitumor activity.

基本信息

经验(实验)分子式	C₂₂H₂₂N₈·2HCl
分子量	471.39
MDL编号	MFCD01743164
PubChem化学物质编号	329773240
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
溶解性	deionized water: 8 mg/mL
储存温度	room temp
SMILES string	Cl.Cl.C1CN=C(N1)N\N=C\c2c3ccccc3c(\C=N\NC4=NCCN4)c5ccccc25
InChI	1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+;;
InChI key	KINULKKPVJYRON-PVNXHVEDSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H400
预防措施声明	P273 - P301 + P312 + P330
危险分类	Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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