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CAS: 7803-49-8
分子式: H3NO
分子量: 33.03
沸点: >100 °C
熔点: 7℃
中文名称: 
羟胺
英文名称: 
hydroxylamine free-base
hydroxylamine,free base
Hydroxylamine
oxammonium
hydroxyl amine
性质描述: 不稳定的白色大片状或针状结晶。极易吸潮,极易溶于水。当浓度为100%、10%、20%、30%、40%、50%时水溶液的相对密度分别为:1.2040、1.0192、1.0410、1.0637、1.0875、1.1122。该品在热水中分解,微溶于乙醚、苯、二硫化碳、氯仿。熔点32.05℃,沸点70℃(1.33kPa)。
生产方法: 用盐酸羟胺乙醇溶液加乙醇钠,将析出的氢氧化钠迅速滤出,滤液冷至-18℃结晶,过滤,得羟胺。将磷酸羟胺加热蒸馏(1.73kPa下操作),收集135-137℃馏分,亦可得羟胺粗品。
用途: 在有机合成中用作还原剂。
推荐供应商
货号品牌产品名称规格包装、参考价格
H902443MACKLIN羟胺10% solution in H2O80元/25ml;   158元/100ml;   512元/500ml;   1998元/2.5L;   咨询
储存:2-8℃, 避光, 干燥
状态:液体
物化性质:Miscible with water, liquid ammonia and methanol. Slightly miscible with ether, benzene, carbon disulfide and chloroform.
折射率:1.3940
H769244MACKLIN羟胺溶液1% in H2O75元/25ml;   128元/100ml;   420元/500ml;   1760元/2.5L;   咨询
储存:2-8℃, 避光, 干燥
状态:液体
H828371MACKLIN羟胺50% solution in H2O38元/5ml;   77元/25ml;   214元/100ml;   728元/500ml;   2793元/2.5L;   10779元/10L;   咨询
储存:2-8℃, 避光, 干燥
状态:液体
物化性质:Miscible with water, liquid ammonia and methanol. Slightly miscible with ether, benzene, carbon disulfide and chloroform.
折射率:1.3940
H790423MACKLIN羟胺2M in H2O80元/25ml;   142元/100ml;   486元/500ml;   1898元/2.5L;   咨询
储存:2-8℃, 避光, 干燥
状态:液体
物化性质:Miscible with water, liquid ammonia and methanol. Slightly miscible with ether, benzene, carbon disulfide and chloroform.
B22202Alfa AesarHydroxylamine50% aq. soln.747元/100ml;   2979元/500ml;   咨询

应用
Hydroxylamine is a reactant used for the preparation of hydroxyaminoguanidines which are anti-cancer agents, carboxamide derivatives of ofloxacin and human immunodeficiency virus (HIV) integrase inhibitors. It reacts with chlorosulfonic acid to give hydroxylamine-O-sulfonic acid, a useful reagent in the synthesis of caprolactam. It is commonly used as a reducing agent in myriad of organic and inorganic reactions. It acts as an antioxidant for fatty acids. It is widely used to prepare oximes, an important functional group.

备注
It can violently decompose at elevated temperatures. May be shock-sensitive if dry. Do not heat over 500C. Incompatible with bases, oxidizing agents, nitrates, nitrites, heavy metals, rubber, metals, epoxides and polyester.

基本信息

MDL
MFCD00044522

EINECS
232-259-2

分子式
H3NO

分子量
33.03

熔点

沸点
107-114°

闪点
None

密度
1.120

折射率
1.3940

灵敏度
Ambient temperatures.

形态
Liquid

溶解性
Miscible with water, liquid ammonia and methanol. Slightly miscible with ether, benzene, carbon disulfide and chloroform.

Beilstein
1098214

Merck
14,4828

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H313-H315-H318-H317-H351-H335-H373-H400
Harmful if swallowed.May be harmful in contact with skin.Causes skin irritation.Causes serious eye damage.May cause an allergic skin reaction.Suspected of causing cancer.May cause respiratory irritation.May cause damage to organs through prolonged or repeated exposure.Very toxic to aquatic life.

Precautionary Statements
P260-P201-P280-P305+P351+P338-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray.Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

UN#
UN3266

危险等级
8

包装组
III

危险类别
21/22-37/38-40-41-43-48/22-50
Harmful in contact with skin and if swallowed.Irritating to respiratory system and skin.Limited evidence of a carcinogenic effect.Risk of serious damage to eyes.May cause sensitization by skin contact.Harmful: danger of serious damage to health by prolonged exposure if swallowed.Very toxic to aquatic organisms.

安全等级
26-36/37/39-46-61
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.If swallowed, seek medical advice immediately and show this container or label.Avoid release to the environment. Refer to special instructions/safety data sheets.

欧盟危险品标志

RTECS
NC2975000

TSCA

438227Sigma-AldrichHydroxylamine solution50 wt. % in H2O1158.82元/250 ML;   4184.58元/1 L;   咨询

产品说明

一般描述

羟胺是一种弱碱,主要用作有机反应中的还原剂。

应用

作为制备下列化合物的反应物:

  • 心血管药物 Nω-羟基-L-精氨酸(NOHA,一氧化氮前体)的前药
  • 羟基氨基胍,作为抗癌药
  • 非甾体2,3-二氢喹啉糖皮质激素受体激动剂,具有降低的磷酸烯醇丙酮酸羧基激酶(PEPCK)转录激活活性
  • 氧氟沙星的羧酰胺衍生物,具有改善的抗菌特性
  • 基于香豆素类似物的TNF-α转化酶(TACE)抑制剂
  • HIV整合酶抑制剂

包装

50, 250 mL in poly bottle

基本信息

线性分子式NH2OH
分子量33.03
EC 号232-259-2
MDL编号MFCD00044522
PubChem化学物质编号24867438

产品性质

蒸汽压9 mmHg ( 40 ℃)
质量水平200
浓度50 wt. % in H2O
bp>100 ℃
密度1.078 g/mL at 25 ℃
web metadata keyword.defaultOxammonium, Azanol, H2NHO, dihydridohydroxidonitrogen, HOA, NH2OH, Hydroxylamine solution supplier, nitrogen cycle, nitrification, electrophiles, 1-Hexadecylamine, 1-hexadecanylamine, 1-Aminohexadecane, Cetylamine, n-Certylamine, 1-hexadecanamine, HAD, Alamine 6, Amine 16D, Armeen 16, Cetylamin, Crodamine, Palmitylamine, palmityl amine.
SMILES stringNO
InChI1S/H3NO/c1-2/h2H,1H2
InChI keyAVXURJPOCDRRFD-UHFFFAOYSA-N

安全信息

象形图GHS05GHS07GHS08GHS09
警示用语:Danger
危险声明H290 - H302 + H312 - H315 - H317 - H318 - H335 - H351 - H373 - H400
预防措施声明P201 - P273 - P280 - P302 + P352 + P312 - P305 + P351 + P338 + P310 - P308 + P313
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3
靶器官Blood, Respiratory system
储存分类代码8A - Combustible, corrosive hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
467804Sigma-AldrichHydroxylamine solution50 wt. % in H2O, 99.999%739.37元/10 ML;   1618.51元/50 ML;   咨询

产品说明

应用

羟胺溶液(NH2OH)可作为反应物用于制备:

  • 来自醛类的伯酰胺,通过芳烃钌(II)络合物催化。
  • 羟基氨基胍和生物研究用氧氟沙星的甲酰胺衍生物。
  • 用于抗体固定化的Fe3O4/Au (GoldMag)纳米颗粒。

作为制备下列化合物的反应物:
  • 心血管药物 Nω-羟基-L-精氨酸(NOHA,一氧化氮前体)的前药
  • 羟基氨基胍,作为抗癌药
  • 非甾体2,3-二氢喹啉糖皮质激素受体激动剂,具有降低的磷酸烯醇丙酮酸羧基激酶(PEPCK)转录激活活性
  • 氧氟沙星的羧酰胺衍生物,具有改善的抗菌特性
  • 基于香豆素类似物的TNF-α转化酶(TACE)抑制剂
  • HIV整合酶抑制剂

包装

10, 50 mL in poly bottle

基本信息

线性分子式NH2OH
分子量33.03
EC 号232-259-2
MDL编号MFCD00044522
PubChem化学物质编号24870439
NACRESNA.22

产品性质

质量水平100
测定99.999%
浓度50 wt. % in H2O
bp107 ℃
密度1.078 g/mL at 25 ℃
SMILES stringNO
InChI1S/H3NO/c1-2/h2H,1H2
InChI keyAVXURJPOCDRRFD-UHFFFAOYSA-N

安全信息

象形图GHS05GHS07GHS08GHS09
警示用语:Danger
危险声明H290 - H302 - H315 - H317 - H318 - H335 - H351 - H373 - H400
预防措施声明P201 - P273 - P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310 - P308 + P313
危险分类Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3
靶器官Blood, Respiratory system
储存分类代码8A - Combustible, corrosive hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
069272FluorochemHydroxylamine (50% solution in water)97%550元/100ml;   1650元/500ml;   咨询

基本信息

CAS Number7803-49-8
MDL NumberMFCD00044522
Melting Point32.05℃
Density1.101

安全信息

图形或危害标志
危险性说明 H290: May be corrosive to metals.
H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H318: Causes serious eye damage.
H335: May cause respiratory irritation.
H351: Suspected of causing cancer ..
H373: May cause damage to organs ..
H400: Very toxic to aquatic life.
防范说明 P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P233: Keep container tightly closed.
P234: Keep only in original container.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should not be allowed out of the workplace.
P273: Avoid release to the environment.
P280: Wear .
P281: Use personal protective equipment as required.
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P310: Immediately call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P314: Get medical advice/attention if you feel unwell.
P321: Specific treatment (see . on this label).
P322: Specific measures (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P333 + P313: If skin irritation or rash occurs: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P390: Absorb spillage to prevent material damage.
P391: Collect spillage.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P406: Store in corrosive resistant/ container with a resistant inner liner.
P501: Dispose of contents/container to local regulations.
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