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CAS: 77-67-8
分子式: C7H11NO2
分子量: 141.17
中文名称: 
乙琥胺
紫浪丁
2-乙基-2-甲基丁二酰亚胺
英文名称: 
3-Ethyl-3-methyl-2,5-pyrrolidinedione
2-ethyl-2-methyl-succinimid
3-ethyl-3-methyl-5-pyrrolidinedione
2-ethyl-2-methylsuccinimide
3-ethyl-3-methyl-2,5-pyrrolidine-dione
3-ethyl-3-methylpyrrolidine-2,5-dione
3-ethyl-3-methylsuccinimide
3-methyl-3-ethylpyrrolidine-2,5-dione
aethosuximide
alpha-ethyl-alpha-methylsuccinimide
alpha-methyl-alpha-ethylsuccinimide
asamid
atysmal
capitus
ci 366
emeside
epileo petit mal
ethosuccimide
ethosuccinimide
ethosuxide
ethosuximide
ethymal
etomal
etosuximid
etosuximida
gamma-methyl-gamma-ethyl-succinimide
h 940
h-490
mesentol
pemal
pemalin
pentinimid
petinimid
petnidan
piknolepsin
pm 671
pyknolepsinum
ronton
simatin
simatin(e)
succimal
succimitin
suxilep
suximal
suxin
suxinutin
thetamid
thilopemal
zaraondan
zarodan
zarondan
zarondan-saft
zarontin
zartalin
展开更多英文名
性质描述: 白色蜡状固体。熔点64-65℃(45-46℃)。易溶于水,极易溶于乙醇,氯仿。有引湿性,几乎无臭,味微苦。
生产方法: 由2-乙基-2-甲基丁二酸(C7H12O4,[631-31-2])用氨水环合而得。将氨水(20%)加入2-乙基-2-甲基丁二酸,至pH为10以上。加热至200-220℃,反应20min。冷至50℃以下,加入氯仿。过滤,滤饼经氯仿洗涤后弃去合并洗、滤液,分取氯仿层。回收氯仿后减压蒸馏,收集150-160℃(2.13kPa)馏分,得乙琥胺。
用途: 是一类较新的抗癫痫药,主要用于癫痫小发作。毒性较小,效果好,为小发作的首选药,应用较普遍。乙琥胺能加重大发作,因此对混有大发作有病人,该品不能单独使用,,必须和苯马比妥或苯妥英纳合用。大鼠口服LD50为1820mg/kg。
推荐供应商
货号品牌产品名称规格包装、参考价格
E795307MACKLIN乙琥胺10mM in DMSO437元/1ml;   咨询
储存:-20°C
E838503MACKLIN乙琥胺98%130元/1g;   490元/5g;   咨询
储存:室温
状态:白色到淡黄色固体
E0746TCIEthosuximide>98.0%(GC)(T)485元/5G;   1255元/25G;   咨询

基本信息

纯度/分析方法>98.0%(GC)(T)
分子式/分子量C7H11NO2 = 141.17
外观与形状(20℃)固体
储存温度0-10℃
储存在惰性气体下存放于惰性气体之中
应避免的情况空气,加热
Reaxys-RN117054
PubChem物质ID87559573
Merck Index (14)3748
MDL编号MFCD00072123

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(GC)min. 98.0 %
Purity(Neutralization titration)min. 98.0 %
Melting point48.0 to 52.0 ℃

物性(参考值)

熔点51 ℃
沸点150 ℃/12 mmHg

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#WN2800000
C46140Alfa AesarEthosuximide796元/5g;   3032元/25g;   8258元/100g;   咨询

基本信息

Ref#
46140

分子式
C7H11NO2

分子量
847.00

GHS危害和防范说明

Hazard Statements
H302 H341 H360D

Precautionary Statements
P301+P330+P331 P312 P264 P201 P280

PH001368Sigma-Aldrich(2-Chloro-5-nitrophenyl)(1-ethyl-3-methyl-1H-pyrazol-5-yl)methanoneAldrichCPR2122.84元/5 MG;   咨询

产品说明

其他说明

Please note that sigma-aldrich provides this product to early discovery researchers as part of a collection of unique chemicals. sigma-aldrich does not collect analytical data for this product. Buyer assumes responsibility to confirm product identity and/or purity. All sales are final.

NOTWITHSTANDING ANY CONTRARY PROVISION CONTAINED IN SIGMA-ALDRICH′S STANDARD TERMS AND CONDITIONS OF SALE OR AN AGREEMENT BETWEEN SIGMA-ALDRICH AND BUYER, SIGMA-ALDRICH SELLS THIS PRODUCT "AS-IS" AND MAKES NO REPRESENTATION OR WARRANTY WHATSOEVER WITH RESPECT TO THIS PRODUCT, INCLUDING ANY (A) WARRANTY OF MERCHANTABILITY; (B) WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE; OR (C) WARRANTY AGAINST INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OF A THIRD PARTY; WHETHER ARISING BY LAW, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE OF TRADE OR OTHERWISE.

基本信息

线性分子式C13H12ClN3O3
MDL编号MFCD12974506

产品性质

SMILES stringO=C(C1=C(Cl)C=CC([N+]([O-])=O)=C1)C2=CC(C)=NN2CC
E7138Sigma-AldrichEthosuximide1124.66元/5 G;   4013.22元/100 G;   咨询

产品说明

应用

乙琥胺已被用于:

  • 证实其对大鼠棘波放电(SWD)的作用
  • 考察其对野生型斑马鱼幼体自发运动和焦虑相关趋触性行为的影响
  • 作为模型药物体内治疗癫痫症(4)

包装

5, 100 g in glass bottle

生化/生理作用

乙琥胺是一种抗惊厥药,同时也是T型钙通道拮抗剂。它可防止失神发作中的棘波放电。

特点和优势

该化合物出现在受体分类和信号转导手册的钙离子通道页。欲浏览其他手册页,点击此处。
该化合物是由辉瑞开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单, 请单击此处。

其他说明

斯克里普斯代谢组学和质谱技术中心独立生成的串联质谱数据可在PDF (E7138.pdf )中查看或下载。斯克里普斯代谢物组学和质谱技术中心的METLIN代谢物数据库中有测试代谢物。要了解更多信息,请访问sigma.com/metlin。

基本信息

经验(实验)分子式C7H11NO2
分子量141.17
EC 号201-048-7
MDL编号MFCD00072123
PubChem化学物质编号24278423
NACRESNA.77

产品性质

质量水平100
溶解性ethanol: 100 mg/mL
创始人Pfizer
SMILES stringO=C1NC(CC1(C)CC)=O
InChI1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI keyHAPOVYFOVVWLRS-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
E2150000EthosuximideEuropean Pharmacopoeia (EP) Reference Standard1213.54元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 55 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C7H11NO2
分子量141.17
MDL编号MFCD00072123
PubChem化学物质编号329799026
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringO=C1NC(CC1(C)CC)=O
InChI1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI keyHAPOVYFOVVWLRS-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHR1413SupelcoEthosuximidePharmaceutical Secondary Standard; Certified Reference Material2945.99元/1 G;   咨询

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Ethosuximide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by micellar liquid chromatography.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3706 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C7H11NO2
分子量141.17
EC 号201-048-7
MDL编号MFCD00072123
PubChem化学物质编号329823384
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to BP 146
traceable to PhEur E2150000
traceable to USP 1264002
储存温度2-8℃
SMILES stringO=C1NC(CC1(C)CC)=O
InChI1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI keyHAPOVYFOVVWLRS-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
68459SupelcoEthosuximideanalytical standard1052.91元/100 MG;   咨询

产品说明

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

基本信息

经验(实验)分子式C7H11NO2
分子量141.17
EC 号201-048-7
MDL编号MFCD00072123
PubChem化学物质编号329760914
NACRESNA.24

产品性质

等级analytical standard
质量水平100
测定≥98.0% (GC)
保质期limited shelf life, expiry date on the label
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)forensics and toxicology
pharmaceutical (small molecule)
veterinary
格式neat
SMILES stringO=C1NC(CC1(C)CC)=O
InChI1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI keyHAPOVYFOVVWLRS-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1264002USPEthosuximideUnited States Pharmacopeia (USP) Reference Standard3231.47元/500 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C7H11NO2
分子量141.17
MDL编号MFCD00072123
PubChem化学物质编号329749785
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringO=C1NC(CC1(C)CC)=O
InChI1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI keyHAPOVYFOVVWLRS-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP146EthosuximideBritish Pharmacopoeia (BP) Reference Standard2208.05元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 200 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C7H11NO2
分子量141.17
EC 号201-048-7
MDL编号MFCD00072123

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringO=C1NC(CC1(C)CC)=O
InChI1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI keyHAPOVYFOVVWLRS-UHFFFAOYSA-N
Gene Informationhuman ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PH001065Sigma-Aldrich4-Ethyl-5-hydroxy-4-methyl-3,4-dihydro-2H-pyrrol-2-oneAldrichCPR2122.84元/25 MG;   咨询

产品说明

其他说明

Please note that sigma-aldrich provides this product to early discovery researchers as part of a collection of unique chemicals. sigma-aldrich does not collect analytical data for this product. Buyer assumes responsibility to confirm product identity and/or purity. All sales are final.

NOTWITHSTANDING ANY CONTRARY PROVISION CONTAINED IN SIGMA-ALDRICH′S STANDARD TERMS AND CONDITIONS OF SALE OR AN AGREEMENT BETWEEN SIGMA-ALDRICH AND BUYER, SIGMA-ALDRICH SELLS THIS PRODUCT "AS-IS" AND MAKES NO REPRESENTATION OR WARRANTY WHATSOEVER WITH RESPECT TO THIS PRODUCT, INCLUDING ANY (A) WARRANTY OF MERCHANTABILITY; (B) WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE; OR (C) WARRANTY AGAINST INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OF A THIRD PARTY; WHETHER ARISING BY LAW, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE OF TRADE OR OTHERWISE.

基本信息

线性分子式C7H11NO2
MDL编号MFCD12974311

产品性质

SMILES stringCC(C1)(CC)C(O)=NC1=O

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
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