CAS 76150-91-9; 2,2'-(1,4-phenylenebis(oxy))bis(3,5-dichloro-pyridin

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货号

品牌

产品名称

规格

包装、参考价格

B932944

MACKLIN

1,4-双((3,5-二氯吡啶-2-基)氧基)苯

97%

598元/100mg; 1207元/250mg; 3812元/1g;

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储存：2-8°C，干燥，密封

B793437

MACKLIN

1, 4-双((3, 5-二氯吡啶-2-基)氧基)苯

10mM in DMSO

335元/1ml;

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储存：-20°C

T1443

Sigma-Aldrich

TCPOBOP

≥98% (HPLC), solid

952.5元/5 MG;

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产品说明

应用

TCPOBOP 已被用于增强小鼠肝癌细胞中 Mcl-1-斜体启动子的功能。TCPOBOP 也被用于研究组成型雄烷受体 (CAR) 诱导小鼠肝细胞基因表达。

包装

5 mg in glass bottle

生化/生理作用

TCPOBOP 作为 CAR 的剂量依赖性直接激动剂，可增强细胞色素 P450 (CYP) 的核受体 CAR 转活。是苯巴比妥类 CYP 诱导剂中已知最有效的成分。

特点和优势

该化合物是细胞凋亡研究的特色产品。点击此处，发现更多特色细胞凋亡产品。如需了解有关生物活性小分子在其他研究领域的更多信息，请访问sigma.com/ discover-bsm。

制备说明

TCPOBOP 可溶于 DMSO，浓度大于 10 mg/mL。不溶于水。

基本信息

经验(实验)分子式	C₁₆H₈N₂O₂Cl₄
分子量	402.06
MDL编号	MFCD00057368
PubChem化学物质编号	24278723

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	white
溶解性	DMSO: >10 mg/mL H₂O: insoluble
储存温度	2-8℃
SMILES string	Clc1cnc(Oc2ccc(Oc3ncc(Cl)cc3Cl)cc2)c(Cl)c1
InChI	1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H
InChI key	BAFKRPOFIYPKBQ-UHFFFAOYSA-N
Gene Information	human ... NR1I3(9970)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

580563

Sigma-Aldrich

TCPOBOP-CAS 76150-91-9-Calbiochem

The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.

2538.8元/25 MG;

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产品说明

一般描述

A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.
The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. Acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR (human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Also suppresses the multidrug resistance gene expression in the mouse liver.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Cytochrome P450 (CYP)-inducing agents
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol.156, 91.
Moore, L.B., et al. 2000. J. Biol. Chem.275, 15122.
Tzameli, I., et al. 2000. Mol. Cell. Biol.20, 2951.
Forman, B.M., et al. 1998. Nature395, 612.
Honkakoski, P., et al. 1998. Mol. Pharmacol.53, 597.
Russell, A.L., et al. 1994. Int. J. Cancer58, 550.
Smith, G., et al. 1993. Biochem. J.289, 807.
Dargani, T.A., et al. 1990. Carcinogenesis11, 1153.
Poland, A., et al. 1980. Mol. Pharmacol.18, 571.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₆H₈Cl₄N₂O₂
分子量	402.06
MDL编号	MFCD00057368

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	−20℃
InChI	1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H
InChI key	BAFKRPOFIYPKBQ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable