CAS 75541-83-2; 2-(4-氟苯甲酰基氨基)甲基苯甲酸酯; exo 1

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货号

品牌

产品名称

规格

包装、参考价格

E877521

MACKLIN

Exo1

99%

450元/10mg; 1576元/50mg; 4208元/250mg;

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储存：2-8℃
状态：白色到灰白色固体

E792547

MACKLIN

Exo1

10mM in DMSO

583元/1ml;

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储存：-20°C

E8280

Sigma-Aldrich

Exo 1

≥98% (HPLC), solid

730.08元/5 MG; 2457.91元/25 MG;

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产品说明

应用

Exo 1 已被用作 BRB80 缓冲液的组成成分，以被用于研究外壳蛋白 1 (COPI) 介导的膜运输。它也被用作高尔基体抑制剂来研究其对长散布的核元件 1 (L1) 逆转录转座的影响。

包装

5, 25 mg in glass bottle

生化/生理作用

Exo 1 是一种可渗透细胞的邻氨基苯甲酸甲酯类似物，可促进二磷酸腺苷 (ADP)-核糖基化因子 (ARF) 1 从高尔基体膜释放。它还可抑制内质网 (ER) 和高尔基体之间的膜运输。
可逆的胞吐抑制剂；高尔基体ARF 1(ADP-核糖基化因子)GTPase激活剂。

基本信息

经验(实验)分子式	C₁₅H₁₂NFO₃
分子量	273.26
MDL编号	MFCD00028104
PubChem化学物质编号	24724477
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
溶解性	DMSO: soluble 19 mg/mL
SMILES string	COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2
InChI	1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)
InChI key	KIAPWMKFHIKQOZ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

341220

Sigma-Aldrich

Exo1-CAS 75541-83-2-Calbiochem

A cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells by inducing tubulation and collapsing of the Golgi membrane.

2118.65元/25 MG;

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产品说明

一般描述

A cell-permeable methylanthranilate analog that reversibly blocks vesicular traffic from the ER to the Golgi in mammalian cells (IC₅₀ = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and re-directing the traffic back to the ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor, Brefeldin A (BFA) (Cat. No. 203729), the effects appear to be limited to the Golgi, as no effects are detected on endocytic organelles, such as endosomes and trans-Golgi network (TGN). The inhibitory mechanism and target(s) appear to be different from those of BFA, thus making it a valuable alternative that complements BFA in membrane trafficking studies.
A cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells (IC₅₀ = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and redirecting the traffic back to ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor Brefeldin A (BFA; Cat. No. 203729), its effect seems to be limited to Golgi, as no effect can be detected on endocytic organelles, such as endosomes and TGN (trans-Golgi network). Its inhibitory mechanism and target(s) appear to be quite different from those of BFA and thus serves as a valuable alternative that complements BFA in membrane traffic studies.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 20 µM inhibiting vesicular traffic from ER to Golgi in BSC1 cells
Product does not compete with ATP.
Primary Target
Golgi ARF1 GTPase
Reversible: yes

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Feng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA100, 6469.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₅H₁₂FNO₃
分子量	273.26
MDL编号	MFCD00028104

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMF: 25 mg/mL DMSO: 25 mg/mL ethanol: 5 mg/mL methanol: 5 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)
InChI key	KIAPWMKFHIKQOZ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable