CAS 7415-69-2; guanosine 5'-diphosphate disodium salt

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货号

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产品名称

规格

包装、参考价格

G810380

MACKLIN

5’-二磷酸鸟苷二钠

90%

40元/100mg; 50元/250mg; 120元/1g; 342元/5g; 1099元/25g; 3353元/100g;

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储存：-20°C
状态：白色粉末或晶体

G6285

MACKLIN

5'-鸟苷二磷酸二钠

生物技术级

218元/100mg; 688元/500mg; 1029元/5g; 3242元/25g;

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储存：−20°C
状态：白色粉末

131323

J&K

Guanosine-5'-diphosphate disodium salt

90%

1469元/100MG; 5120元/500MG;

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基本信息

分子式	C₁₀H₁₃N₅Na₂O₁₁P₂
分子量	487.16
MDL编码	MFCD00084665
EINECS 编号	231-026-2
存储条件	Freezer -20℃

安全信息

防范说明	P262
WGK	3
TSCA	否

51060

Sigma-Aldrich

Guanosine 5′-diphosphate disodium salt

≥90% (HPLC)

2240.59元/100 MG; 7770.67元/500 MG;

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产品说明

一般描述

Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.

应用

Guanosine 5′-diphosphate disodium salt has been used:

in fluorescent metal nanoclusters selectivity of guanosine 3′-diphosphate-5′-di(tri)phosphate, ppGpp
in screening of fluorescence emission of hypocrellin A-zinc complex
as a component of assay buffers in the autoradiography of mice brain sections

Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.

生化/生理作用

Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).

基本信息

经验(实验)分子式	C₁₀H₁₃N₅Na₂O₁₁P₂
分子量	487.16
EC 号	231-026-2
MDL编号	MFCD00084665
PubChem化学物质编号	57651304
NACRES	NA.51

产品性质

质量水平	100
生物来源	Porcine brain microbial (Corynebacterium sp) synthetic
测定	≥90% (HPLC)
形式	powder
溶解性	H₂O: 50 mg/mL, clear, colorless
运输	dry ice
储存温度	−20℃
SMILES string	[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
InChI	1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
InChI key	LTZCGDIGAHOTKN-LGVAUZIVSA-L

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)