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CAS: 74103-07-4
分子式: C19H24N2O6
分子量: 376.4
中文名称: 
辛太克斯(浮选剂)
英文名称: 
3-dihydro-5-benzoyl- (+-)- compd. with 2-1h-pyrrolizine-1-carboxylic aci
amino-2- (hydroxymethyl)-1,3-propanediol (1:1)
ketorolac tromethamine
syntex
toradol
1h-pyrrolizine-1-carboxylic acid,2,3-dihydro-5-benzoyl-, (+-)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
推荐供应商
货号品牌产品名称规格包装、参考价格
K860219MACKLIN酮咯酸氨丁三醇98%92元/1g;   283元/5g;   968元/25g;   3700元/100g;   咨询
储存：室温,干燥
状态：白色到几乎白色晶体或粉末
K797729MACKLIN酮咯酸氨丁三醇10mM in DMSO116元/1ml;   咨询
储存：-20°C
K0053TCIKetorolac Tromethamine>98.0%(T)(HPLC)430元/1G;   1640元/5G;   咨询

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C15H13NO3・C4H11NO3 = 376.41
外观与形状(20℃)固体
相关CAS RN74103-06-3
Reaxys-RN6463165
PubChem物质ID253661330
Merck Index (14)5306
MDL编号MFCD00887595

技术规格

AppearanceWhite to Light yellow powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Neutralization titration)min. 98.0 %

物性(参考值)

熔点167 ℃
最大吸收波长322(MeOH) nm

安全信息

图形或危害标志
信号词危险
危险性说明H301 : 吞咽会中毒。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#UY7759900

运输信息

UN编号UN2811
类别6.1
包装类别 III
监管条件代码(*)
526973J&KKetorolac Tromethamine98%371元/1G;   1416元/5G;   咨询

基本信息

分子式C15H13NO3·C4H11NO3
分子量376.41
熔点164
MDL编码MFCD00887595
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Danger
危险说明H301
H315
H319
H335
防范说明P301+P310+P330
P302+P352
P305+P351+P338
UN号码2811
危险分类6.1
包装等级III
WGK3
RTECSUY7759900
K1136Sigma-AldrichKetorolac Tris Salt≥99%, crystalline2005.34元/1 G;   7979.47元/5 G;   咨询

产品说明

应用

酮咯酸已被用于：

  • 小鼠腹膜内注射，用于研究酮咯酸对ARC(下丘脑弓状核)POMC(促黑素皮质激素)-EGFP(增强型绿色荧光蛋白)神经元中c-Fos(人类原癌基因)表达的影响。
  • 对小鼠进行治疗，以研究这种治疗方法不会阻止IL-1β介导的抑制小鼠下丘脑外植体分泌Agouti相关蛋白(AgRP)的分泌。
  • 通过将角叉菜胶注射到脚踝作为镇痛药来治疗急性炎症性关节损伤的大鼠

包装

1, 5 g in poly bottle

生化/生理作用

酮咯酸是一种非甾体类药物，具有中度消炎活性，同时也是一种强效的止痛药。在中度至重度术后疼痛患者中，它具有优于吗啡等阿片类止痛片的止痛作用。它会抑制花生四烯酸和胶原蛋白引发的前列腺素合成和血小板聚集。它是一种双重COX-1 / COX-2抑制剂。

注意

如在室温下储存，至少可稳定 2 年。

基本信息

经验(实验)分子式C15H13NO3 · C4H11NO3
分子量376.40
MDL编号MFCD00887595
PubChem化学物质编号24278503
NACRESNA.77

产品性质

生物来源synthetic (organic)
质量水平100
测定≥99%
形式crystalline
溶解性H2O: soluble 15 mg/mL, clear, colorless to faintly yellow (stable at least one month at −20 ℃.)
储存温度room temp
SMILES stringNC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
InChI1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChI keyBWHLPLXXIDYSNW-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742), PTGS2(5743)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301 - H315 - H319 - H335
预防措施声明P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Y0000626Ketorolac trometamol for peak identificationEuropean Pharmacopoeia (EP) Reference Standard1559.78元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H13NO3 · C4H11NO3
分子量376.40
MDL编号MFCD00887595
PubChem化学物质编号329831061
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringNC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
InChI1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChI keyBWHLPLXXIDYSNW-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742), PTGS2(5743)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301 - H315 - H319 - H335
预防措施声明P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
Y0000486Ketorolac trometamolEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H13NO3 · C4H11NO3
分子量376.40
MDL编号MFCD00887595
PubChem化学物质编号329830978
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringNC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
InChI1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChI keyBWHLPLXXIDYSNW-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742), PTGS2(5743)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301 - H315 - H319 - H335
预防措施声明P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHR1140SupelcoKetorolac TromethaminePharmaceutical Secondary Standard; Certified Reference Material1025.53元/500 MG;   咨询

产品说明

一般描述

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。酮咯酸氨丁三醇属于非甾体类抗炎药，其作用方式涉及到抑制前列腺素的合成。它具有抗炎、解热、镇痛作用。

应用

这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
酮咯酸氨丁三醇可作为药物参考标准品，通过反相高效液相色谱和分光光度法技术对药物制剂中的分析物进行定量。

分析说明

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他说明

分析物的数值在批次间变化很大。
该认证参考物质(CRM)根据 ISO 17034和 ISO/IEC 17025进行生产和认证。所有关于客户关系管理的信息都可以在分析证书上找到。

附注

要查看该材料的分析证书示例，请在下方栏位输入 LRAA7191。这只是一个示例证书，可能不是您收到的批次。

基本信息

经验(实验)分子式C15H13NO3 · C4H11NO3
分子量376.40
MDL编号MFCD00887595
PubChem化学物质编号329823160
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to PhEur Y0000486
traceable to USP 1356665
储存温度2-30℃
SMILES stringNC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
InChI1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChI keyBWHLPLXXIDYSNW-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742), PTGS2(5743)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301 - H315 - H319 - H335
预防措施声明P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1356665USPKetorolac TromethamineUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C15H13NO3 · C4H11NO3
分子量376.40
MDL编号MFCD00887595
PubChem化学物质编号329750219
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringNC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
InChI1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChI keyBWHLPLXXIDYSNW-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742), PTGS2(5743)

安全信息

象形图GHS06
警示用语：Danger
危险声明H301 - H315 - H319 - H335
预防措施声明P301 + P330 + P331 + P310 - P305 + P351 + P338
危险分类Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
M02042FluorochemKetrolac.Tromethamine Salt>99%880元/1g;   3256元/5g;   咨询

基本信息

CAS Number74103-07-4
MDL NumberMFCD00887595
Melting Point165-167℃

安全信息

图形或危害标志
危险性说明 H301: Toxic if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9
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