| CAS: | 73069-13-3 | |
| 分子式: | C15H18O2 | |
| 分子量: | 230.3 | |
| 沸点: | 405.0±44.0 °C | |
| 熔点: | 121-123 °C | |
| 英文名称: |
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| 性质描述: | 可溶于甲醇、乙醇、DMSO等有机溶剂，来源于白术 | |
| 用途: | 白术内酯I(Atractylenolide-I)是从白术中提取的一种天然化合物，可诱导细胞凋亡而导致HL-60细胞的细胞毒性，TLR4拮抗剂。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||
| A793909 | MACKLIN | 白术内酯 I | 10mM in DMSO | 480元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||
储存：-20°C, 避光 | |||||||||||||||||||||||||||||||||||||
| A860603 | MACKLIN | 白术内酯 I | 分析对照品, ≥98%(HPLC) | 1299元/10mg; 3700元/50mg; | 咨询 | ||||||||||||||||||||||||||||||||
储存：2-8°C，密封，干燥，避光 状态：白色到灰白色粉末或晶体 物化性质：可溶于甲醇、乙醇、DMSO等有机溶剂，来源于白术 | |||||||||||||||||||||||||||||||||||||
| 796286 | J&K | Atractylenolide I | 98%, 从白术根中得到的倍半萜烯, 具有神经保护, 抗过敏, 抗炎和抗癌等多种生物活性, Atractylenolide I 为 TLR4 的拮抗剂, 同时在 A375 细胞中, 能够降低 JAK2 和 STAT3 的磷酸化水平 | 855元/5MG; 1425元/10MG; | 咨询 | ||||||||||||||||||||||||||||||||
基本信息
产品描述 Atractylenolide I 是A. macrocephala根茎的主要类倍半萜烯类化合物。具有广谱的药理活性，如抗炎、促消化、抗氧化作用。 体外研究 Atractylenolide I在受到LPS激活的腹膜巨噬细胞种，以浓度依赖性方式降低TNF-α的水平，IC50=23.1 μM。它还能够抑制NO的生成，IC50=41 μM。Atractylenolide I抑制iNOS活性的IC50为67.3 μM，对5-lipoxygenase (5-LOX)和cyclooxygenase (COX)没有显著影响。Atractylenolide I作用于白细胞膜和TLR4，通过拮抗TLR4发挥抗炎活性[1]。 体内研究 Atractylenolide I具有抗炎效果。在LPS诱导急性肺损伤的小鼠模型中，Atractylenolide I能显著地减弱LPS诱导的肺的湿干重量比和MPO活性。它还能在气管肺泡灌洗液中，显著抑制TNF-α、IL-6、IL-1β、IL-13和MIF生成，同时还有灌洗液中的中性粒细胞和巨噬细胞，上调其中IL-10的产生。Atractylenolide I能够通过抑制TLR4的表达和NF-κB激活，保护受到LPS诱发的急性肺损伤的小鼠[2]。 细胞实验 Cell lines: 腹膜巨噬细胞 Concentrations: 1-1000 μM Incubation Time: 24 h Method: 将细胞以2 × 104细胞/孔的密度铺于96孔板，加入200μL培养基，于37℃培养24小时，然后更换新的培养基。用1-1000 μM atractylenolide I处理细胞，或是LPS（终浓度10 μg/mL）和atractylenolide I（1-100 μM）组合，或单独处理LPS。37℃处理24小时后，向每孔加入20 μL MTT(5 mg/mL)，4小时后，将细胞溶解于150 μL DMSO。将培养板置于摇床上摇晃10分钟，30分钟后检测吸光值。 (Only for Reference) 动物实验 Animal Models: LPS诱导的急性肺损伤小鼠模型 Formulation: -- Dosages: 5, 10 和 20 mg/kg Administration: i.p. (Only for Reference) 参考文献 [1] Li CQ, et al. Phytother Res. 2007, 21(4):347-53. [2] Zhang JL, et al. Eur J Pharmacol. 2015, 765:94-9. | |||||||||||||||||||||||||||||||||||||
| A2737 | Sigma-Aldrich | Atractylenolide I | ≥98% (HPLC) | 2869.64元/10 MG; | 咨询 | ||||||||||||||||||||||||||||||||
产品说明 一般描述 Atractylenolide I is one of the active ingredients of Rhizoma Atractylodes macrocephala which is obtained from the dried root and stem of Atractylodes Macrocephala Koidz. It is a sesquiterpene compound of hydrophobic nature. 应用 Atractylenolide I is a phytochemical that may be used to study its anti-inflammatory and anti-angiogenesis activities. Atractylenolide I may be used and studied as a postitive modulator of GABA-induced chloride currents I(GABA) and as an inhibitor of aromatases. Atractylenolide I may be used as a reference material in assays to detect its presence in plant root extracts and biological milieu such as plasma. 包装 10 mg in glass bottle 生化/生理作用 Atractylenolide I has been reported to have an anti-inflammatory activity due to its inhibitory effect on tumor necrosis factor-α (TNF-α) and the production of nitric oxide (NO). It also shows anti-cancer nature, thereby being used in the management of gastric cancer cachexia symptoms. Additionally, it has anti-angiogenic, pro-oxidative and cytotoxic characteristics. 基本信息
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| PHL82479 | Atractylenolide I | phyproof® Reference Substance | 8228.03元/10 MG; | 咨询 | |||||||||||||||||||||||||||||||||
产品说明 一般描述 This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG 生化/生理作用 Phytochemical from Traditional Chinese Medicine herbal preparations. Atractylenolide I is an anti-inflammatory that is reported to inhibit angiogenesis. 法律信息 phyproof is a registered trademark of PhytoLab GmbH & Co. KG 基本信息
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