CAS 724741-75-7; stf-31 - �뵺�羺�ٷ��ַ

CAS:

724741-75-7

分子式:

C₂₃H₂₅N₃O₃S

分子量:

423.53

英文名称:

stf-31

4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-n-3-pyridinyl-benzamide

用途:

STF-31是一种选择性葡萄糖转运蛋白GLUT1抑制剂。STF-31特异性靶向作用于通过GLUT1的葡萄糖摄取，从而选择性杀死RCCs。STF-31显著抑制VHL-缺失细胞中60%的乳酸产生和胞外酸化，并通过减少葡萄糖转运减少糖酵解。[1]在表达NAPRT1的细胞中，STF-31通过抑制NAMPT酶活性表现出细胞毒性。[2] STF-31对hPSCs是有毒的，并且足以从混合的培养物中选择性清除hPSCs。[3]

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

S793659

MACKLIN

STF-31

10mM in DMSO

516元/1ml;

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储存：-20°C

S872879

MACKLIN

STF-31

99%

375元/5mg; 1211元/25mg;

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储存：-20℃
状态：白色到米黄色粉末

SML1108

Sigma-Aldrich

STF-31

≥98% (HPLC)

1399.43元/5 MG; 5643.95元/25 MG;

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产品说明

应用

STF-31 has been used in glucose transporter 1 (GLUT1) inhibition.

包装

5, 25 mg in glass bottle

生化/生理作用

STF-31 selectively inhibits the glucose transporter GLUT1 and selectively impairs cancer cell growth of kidney and other types of cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor protein. Inactivation of VHL increases the activity of hypoxia-inducible factor transcription factor HIF, which in turn stimulates the transcription of genes involved in glucose metabolism, including the GLUT1 gene. VHL-deficient cancer cells, which include about 80% of renal cell carcinomas, are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. STF-31 binds directly to the GLUT1 transporter, blocking glucose uptake, resulting in necrosis in VHL-deficient cancer cells, but not in normal cells or cancer cells with intact VHL.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₂₃H₂₅N₃O₃S
分子量	423.53
MDL编号	MFCD04153828
PubChem化学物质编号	329825483

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	−20℃
SMILES string	O=C(NC1=CN=CC=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2
InChI	1S/C23H25N3O3S/c1-23(2,3)19-10-12-21(13-11-19)30(28,29)25-15-17-6-8-18(9-7-17)22(27)26-20-5-4-14-24-16-20/h4-14,16,25H,15H2,1-3H3,(H,26,27)
InChI key	NGQPRVWTFNBUHA-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable