CAS 701232-20-4; t863 - �뵺�羺�ٷ��ַ

CAS:

701232-20-4

分子式:

C₂₂H₂₆N₄O₃

分子量:

394.47

英文名称:

t863

t-863

2-((1,4-trans)-4-(4-(4-amino-7,7-dimethyl-7h-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid

trans-4-[4-(4-amino-7,7-dimethyl-7h-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid

用途:

T863 是选择性，有口服活性的二酰基甘油酰基转移酶1 (DGAT1) 抑制剂，能结合DGAT1的酰基辅酶A结合位点，抑制三酰甘油在细胞内的合成。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

T877741

MACKLIN

T863

≥98%

699元/5mg; 999元/10mg; 1599元/25mg; 4999元/100mg;

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储存：2-8℃

SML0539

Sigma-Aldrich

T863

≥98% (HPLC)

1714.02元/5 MG; 5250.73元/25 MG;

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产品说明

应用

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:

to provide the opportunity to precisely control the DGAT inhibition
to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
to specifically block neutral lipid synthesis and lipid droplet formation in HT-1080 cells
to block lipid droplet (LD) formation

包装

5, 25 mg in glass bottle

生化/生理作用

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

基本信息

经验(实验)分子式	C₂₂H₂₆N₄O₃
分子量	394.47
MDL编号	MFCD11977270
PubChem化学物质编号	329825541
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 15 mg/mL (clear solution)
储存温度	2-8℃
SMILES string	CC1(C)Oc2ncnc(N)c2N=C1c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
InChI	1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
InChI key	FUIYMYNYUHVDPT-HDJSIYSDSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

434662

Fluorochem

2-((1R,4R)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid

95%

12716元/250mg; 31746元/1g;

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基本信息

CAS Number	701232-20-4
MDL Number	MFCD11977270