CAS 68550-75-4; cilostamide - �뵺�羺�ٷ��ַ

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货号

品牌

产品名称

规格

包装、参考价格

O872977

MACKLIN

Cilostamide

99%

65元/5mg; 273元/25mg; 636元/100mg; 1142元/250mg;

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储存：-20℃
状态：白色到灰白色到米黄色结晶固体

O792370

MACKLIN

Cilostamide

10mM in DMSO

620元/1ml;

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储存：-20°C

C7971

Sigma-Aldrich

Cilostamide

phosphodiesterase inhibitor

5452.52元/5 MG;

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产品说明

生化/生理作用

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC₅₀= 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.
PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.

基本信息

经验(实验)分子式	C₂₀H₂₆N₂O₃
分子量	342.43
MDL编号	MFCD00673958
PubChem化学物质编号	24278337
NACRES	NA.77

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	powder
溶解性	DMSO: 20 mg/mL, clear, colorless to faintly yellow
SMILES string	CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
InChI	1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
InChI key	UIAYVIIHMORPSJ-UHFFFAOYSA-N
Gene Information	human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150) rat ... Pde2a(81743), Pde4a(25638)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

231085

Sigma-Aldrich

Cilostamide-CAS 68550-75-4-Calbiochem

A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 70 nM).

4137.78元/10 MG;

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产品说明

一般描述

A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 70 nM).

包装

10 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Primary Target
PDE 3
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 70 nM against PDE III

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

其他说明

Verghese, M.W., et al. 1995. J. Pharmacol. Exp. Ther. 272, 1313.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₀H₂₆N₂O₃
分子量	342.43
MDL编号	MFCD00673958

产品性质

质量水平	100
测定	≥98% (TLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
InChI key	UIAYVIIHMORPSJ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable