基本信息

安全信息

图形或危害标志
提示语	Danger
危险说明	H302 H317 H334
防范说明	P261 P280 P342+P311
WGK	1
RTECS	MU2800000
TSCA	是

应用
Nitrofurantoin is a nitrofuran antibiotic that is used as a substrate of bacterial nitrofuran reductase to study the interactions of active metabolites with DNA, ribosomal proteins and metabolic and pro-oxidant processes. It is an antibactericidal compound that has been historically prepared by the reaction of 1-aminohydantoin sulfate and 5-nitro-2-furaldehyde diacetate. It shows activity against many Gram-positive and Gram-negative bacteria. Nitrofurantoin is effective against enterococci, staphylococci, streptococci, corneybacteria, many strains of Escherichia coli.

备注
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Store under dry inert gas. It is hygroscopic in nature. Incompatible with oxidizing agents. It is sensitive to light.

基本信息

MDL
MFCD00003224

EINECS
200-646-5

分子式
C₈H₆N₄O₅

分子量
238.16

熔点
ca 265° dec.

灵敏度
Hygroscopic. Light Sensitive. Store under Nitrogen. Ambient temperatures.

形态
Powder

溶解性
Soluble in water (<0.01 g/100 ml at 19°C), dimethyl sulfoxide and methanol.

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H334-H317
Harmful if swallowed.May cause allergy or asthma symptoms or breathing difficulties if inhaled.May cause an allergic skin reaction.

Precautionary Statements
P284-P261-P280g-P304+P340-P342+P311a-P501a
Wear respiratory protection.Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22-42/43
Harmful if swallowed.May cause sensitization by inhalation and skin contact.

安全等级
22-24-37-45-60
Do not breathe dust.Avoid contact with skin.Avoid contact with skin.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
MU2800000

TSCA
是

安全信息

危险等级
3

安全信息

危险等级
3

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Nitrofurantoin, a synthetic, nitrofuran-derivative, is a widely used urinary antimicrobial compound that is effective against pulmonary fibrosis, neuropathy, hepatitis and hemolytic anemia.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Nitrofurantoin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by voltammetry and chromatography techniques.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA9007 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H317 - H334
预防措施声明	P280 - P301 + P312 + P330 - P302 + P352
危险分类	Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

产品说明

一般描述

呋喃妥因是一种抗生素，能够有效对抗革兰氏阳性和阴性菌。该药主要用于治疗尿路感染。

应用

有关合适仪器技术的更多信息，请参考产品′s分析证书。如需进一步支持，请联系技术服务。
呋喃妥因已被用作高效液相色谱-电化学检测法测定牛奶中呋喃妥因含量的参考标准品。

法律信息

VETRANAL is a registered trademark of sigma-aldrich Chemie GmbH

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H317 - H334
预防措施声明	P261 - P264 - P280 - P301 + P312 - P302 + P352 - P304 + P340 + P312
危险分类	Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 1
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品说明

应用

呋喃妥因是一种硝基呋喃类抗生素，用作细菌硝基呋喃还原酶的底物，研究活性代谢物与 DNA、核糖体蛋白以及代谢和促氧化过程的相互作用。用于研究呋喃妥因引起的毒性 及抗生素耐药性 。呋喃妥因适合于体外杀灭单核细胞增生性李斯特菌。研究描述了使用抗氧化剂减轻呋喃妥因对培养人 WI-38 成纤维细胞的毒性作用。据报道，包括呋喃妥因在内的各种抗生素可引起离体牛乳腺多形核白细胞体外形态特征、活力和吞噬活性的改变。

包装

10, 25, 100, 250 g in glass bottle

生化/生理作用

呋喃妥因是一种抗菌化合物，历史上一直通过 1-氨基乙内酰硫酸酯与 5-硝基-2-呋喃甲醛二乙酸酯反应制备。对许多革兰阳性菌和革兰阴性菌有抗菌活性。呋喃妥因对肠球菌、葡萄球菌、链球菌、角质菌、许多大肠埃希氏菌 菌株和 变形杆菌属的大多数菌株有效 。且 假单胞菌绿脓杆菌 对该化合物的抗性更强。呋喃妥因被细菌黄素蛋白(硝基呋喃还原酶)激活，主动还原调节和损伤核糖体蛋白或其他大分子(如 DNA)的活性中间体。这抑制了导致细胞死亡的 DNA、RNA、蛋白质和细胞壁合成 。呋喃妥因具有较低的耐药潜力，可被哺乳动物迅速代谢，对革兰阳性菌和革兰阴性菌均有活性。它也是一种促氧化剂，由于产生细胞内 H₂O₂ 而具有细胞毒性。为谷胱甘肽还原酶抑制剂。呋喃妥因通过硝基及其自由基阴离子的氧化还原循环产生肝毒性，导致氧化应激。

其他说明

将容器密闭保存在干燥和通风良好的地方。对光敏感。

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H317 - H334
预防措施声明	P280 - P301 + P312 + P330 - P302 + P352
危险分类	Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H317 - H334
预防措施声明	P280 - P301 + P312 + P330 - P302 + P352
危险分类	Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

基本信息

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H317: May cause an allergic skin reaction. H319: Causes serious eye irritation. H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335: May cause respiratory irritation. H361fd: Reproductive toxicity
防范说明	P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear . P285: In case of inadequate ventilation wear respiratory protection. P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P304 + P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P333 + P313: If skin irritation or rash occurs: Get medical advice/attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P342 + P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P362: Take off contaminated clothing and wash before reuse. P363: Wash contaminated clothing before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.