CAS 6632-09-3; nsc57969 - �뵺�羺�ٷ��ַ

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CAS:

6632-09-3

英文名称:

nsc57969

8-hydroxy-7-(piperidinomethyl)quinoline

7-(piperidinomethyl)-8-quinolinol

7-(1-piperidinylmethyl)-8-quinolinol

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货号

品牌

产品名称

规格

包装、参考价格

SML1863

Sigma-Aldrich

NSC57969

≥98% (HPLC)

1117.23元/5 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

NSC57969 is a MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp.

基本信息

经验(实验)分子式	C₁₅H₁₈N₂O
分子量	242.32
MDL编号	MFCD00469245
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	OC1=C(N=CC=C2)C2=CC=C1CN3CCCCC3
InChI	1S/C15H18N2O/c18-15-13(11-17-9-2-1-3-10-17)7-6-12-5-4-8-16-14(12)15/h4-8,18H,1-3,9-11H2
InChI key	WXMFPLZGDXLEMN-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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