CAS 656247-17-5; 尼达尼布; bibf 1120 - �뵺�羺�ٷ��ַ

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货号

品牌

产品名称

规格

包装、参考价格

N796015

MACKLIN

尼达尼布

10mM in DMSO

510元/1ml;

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储存：-20°C
状态：浅黄色至黄色固体

N856623

MACKLIN

尼达尼布

99%

30元/25mg; 55元/100mg; 150元/500mg; 189元/1g; 697元/5g; 2567元/25g; 8295元/100g;

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储存：室温,干燥
状态：浅黄色到黄色到绿色粉末或固体

SML2848

Sigma-Aldrich

Nintedanib

≥98% (HPLC)

779.1元/5 MG; 2521.28元/25 MG;

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产品说明

生化/生理作用

Nintedanib (BIBF1120) is an orally active, potent ATP-competitive inhibitor against angiokinases VEGFR-1/2/3 (IC₅₀ = 34/21/13 nM), FGFR-1/2/3/4 (IC₅₀ = 69/37/108/610 nM), PDGFRα/β (IC₅₀ = 59/65 nM), as well as Flt-3, Lck, Lyn, and Src (IC₅₀ = 26, 16, 195, 156 nM, repectively), but not 33 other kinases. Nintedanib exhibits antiangiogenic and antifibrotic efficacy in cultures and in animal models of cancers and pulmonary fibrosis in vivo.

基本信息

经验(实验)分子式	C₃₁H₃₃N₅O₄
分子量	539.62
MDL编号	MFCD11974012

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(NC1=C2)/C(C1=CC=C2C(OC)=O)=C(C3=CC=CC=C3)\NC4=CC=C(C=C4)N(C(CN5CCN(CC5)C)=O)C

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H315 - H318 - H361fd - H372
预防措施声明	P201 - P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
危险分类	Acute Tox. 3 Oral - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - STOT RE 1
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

050741

Fluorochem

Nintedanib

97%

3300元/1g; 8800元/5g;

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基本信息

CAS Number	656247-17-5
MDL Number	MFCD11974012
Melting Point	244-251℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .