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CAS: 65-71-4
分子式: C5H6N2O2
分子量: 126.11
熔点: 316-317℃
中文名称: 
5-甲基-2,4(1H,3H)-嘧啶二酮
5-甲基-脲嘧啶
胸腺嘧啶
5-甲基脲嘧啶
英文名称: 
4(1H,3H)-Pyrimidinedione, 5-methyl-2
3h)-pyrimidinedione, 5-methyl-4(1h
5-methyluracil
thymin (purine base)
thymine
2,4-dihydroxy-5-methylpyrimidine
Thymin
2,4(1H,3H)-Pyrimidinedione,5-methyl-
5-Methyl-2,4(1H,3H)-pyrimidinedione
5-Methyl-2,4-dihydroxypyrimidine
5-Methylpyrimidine-2,4-dione
2,4-Dihydroxy-5-methylpyrimidin
5-Methyl-1H-pyrimidine-2,4-dione
5-Methyl-uracil
展开更多英文名
性质描述: 该品为白色结晶粉末,常温难溶于水,微溶于醇,溶于碱液、酸、甲酰胺,DMF及吡啶。熔点320-330℃。
用途: 5-甲基嘧啶是遗传物质的重要组成部分,是合成抗艾滋病药物AZT、DDT及相关药物的关键中间体,也是合成抗肿瘤,抗病毒药物β-胸苷的起始原料。
推荐供应商
货号品牌产品名称规格包装、参考价格
T794543MACKLIN胸腺嘧啶10mM in DMSO230元/1ml;   咨询
储存:-20°C
T819296MACKLIN胸腺嘧啶99%29元/5g;   49元/25g;   79元/100g;   299元/500g;   1302元/2.5kg;   咨询
储存:室温
状态:白色到灰白色粉末
T0234TCIThymine>98.0%(T)(HPLC)105元/5G;   330元/25G;   970元/100G;   咨询

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C5H6N2O2 = 126.12
外观与形状(20℃)固体
Reaxys-RN607626
PubChem物质ID87576220
SDBS (AIST Spectral DB)1089
Merck Index (14)9398
MDL编号MFCD00006026

技术规格

AppearanceWhite powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Neutralization titration)min. 98.0 %

物性(参考值)

熔点320 ℃(dec.)
最大吸收波长265(H2O) nm

安全信息

信号词警告
危险性说明H303 : 吞咽可能有害。
防范说明P312 : 如感觉不适,呼叫急救中心/医生。

相关法规

RTECS#XP2100000
207930J&KThymine99%63元/5G;   132元/25G;   331元/100G;   咨询

基本信息

分子式C5H6N2O2
分子量126.11
熔点320
MDL编码MFCD00006026
Beilstein117880
Merck14,9398
EINECS 编号200-616-1

一般描述

胸腺嘧啶是脱氧核糖核酸(DNA)中发现的四个核碱基之一,其他三种包括腺嘌呤、鸟嘌呤和胞嘧啶。

应用

胸腺嘧啶已作为标准含氮碱基,用于高效液相色谱-紫外线(HPLC-UV)(用于定量骨DNA样品)和 拉曼散射实验中。它也已被用作C2C12成肌细胞的补充剂。胸腺嘧啶可用于研究影响DNA结构的化学过程,例如辐射诱导的自由基产生,从而导致碱基发生交联反应和衍生化。它可用于研究与其他核碱基(如腺嘌呤)的氢键动力学和能量参数。胸腺嘧啶可用于基于配位化学和纳米粒子结构开发灵敏的重金属(汞)检测器。

生化/生理作用

用于研究DNA结构的胸腺嘧啶通过辐照方法以进行交联反应和衍生化。胸腺嘧啶二聚体可用来表示DNA损伤。胸腺嘧啶与金属(汞)一起使用可形成胸腺嘧啶-HgII-胸腺嘧啶(T-HgII-T)双链体。在细菌中进行胸腺嘧啶饥饿会导致DNA合成停止,这被称为无胸腺嘧啶死亡。

安全信息

WGK2
RTECSXP2100000
TSCA
A15879Alfa AesarThymine97%817元/25g;   2492元/100g;   10463元/500g;   咨询

应用
Thymine is one of the four nucleobases, along with adenine, guanine and cytosine found in deoxyribonucleic acids (DNA). Thymine may be used to study chemical processes that affect DNA structure, such a radiation induced radical production leading to base cross-linking reactions and derivitizations. Thymine may be used to study the parameters of hydrogen bonding kinetics and energies with other nucleobases such as adenine. Thymine is used to develop sensitive heavy metal (mercury) detectors based on coordination chemistry and nanoparticle structures.

备注
Store in cool dry place.. Keep away from oxidizing agents and acids.

基本信息

MDL
MFCD00006026

EINECS
200-616-1

分子式
C5H6N2O2

分子量
126.12

熔点
316-317°

灵敏度
Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in hot water. Slightly soluble in alcohol.

Beilstein
607626

Merck
14,9398

安全信息

RTECS
XP2100000

TSCA

C15785Alfa AesarThymine99%532元/5g;   866元/25g;   2977元/100g;   11373元/500g;   咨询

基本信息

Ref#
15785

MDL
6026

分子式
C5 H6 N2 O2

分子量
126.11

形态
White crystalline powder

1724532USPZidovudine Related Compound CUnited States Pharmacopeia (USP) Reference Standard10218.8元/100 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C5H6N2O2
分子量126.11
Beilstein117880
MDL编号MFCD00006026
PubChem化学物质编号329751281
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp~320 ℃ (dec.) (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCC1=CNC(=O)NC1=O
InChI1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
InChI keyRWQNBRDOKXIBIV-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
T0376Sigma-AldrichThymine≥99%684.83元/5 G;   822.05元/10 G;   851.36元/25 G;   2386.23元/100 G;   咨询

产品说明

一般描述

胸腺嘧啶是脱氧核糖核酸(DNA)中发现的四个核碱基之一,其他三种包括腺嘌呤、鸟嘌呤和胞嘧啶。

应用

胸腺嘧啶已作为标准含氮碱基,用于高效液相色谱-紫外线(HPLC-UV)(用于定量骨DNA样品)和 拉曼散射实验中。它也已被用作C2C12成肌细胞的补充剂。胸腺嘧啶可用于研究影响DNA结构的化学过程,例如辐射诱导的自由基产生,从而导致碱基发生交联反应和衍生化。它可用于研究与其他核碱基(如腺嘌呤)的氢键动力学和能量参数。胸腺嘧啶可用于基于配位化学和纳米粒子结构开发灵敏的重金属(汞)检测器。

包装

5, 10, 25, 100 g in poly bottle

生化/生理作用

用于研究DNA结构的胸腺嘧啶通过辐照方法以进行交联反应和衍生化。胸腺嘧啶二聚体可用来表示DNA损伤。胸腺嘧啶与金属(汞)一起使用可形成胸腺嘧啶-HgII-胸腺嘧啶(T-HgII-T)双链体。在细菌中进行胸腺嘧啶饥饿会导致DNA合成停止,这被称为无胸腺嘧啶死亡。

基本信息

经验(实验)分子式C5H6N2O2
分子量126.11
Beilstein117880
EC 号200-616-1
MDL编号MFCD00006026
PubChem化学物质编号24899883

产品性质

质量水平200
测定≥99%
mp~320 ℃ (dec.) (lit.)
SMILES stringCC1=CNC(=O)NC1=O
InChI1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
InChI keyRWQNBRDOKXIBIV-UHFFFAOYSA-N
Gene Informationmouse ... Tymp(72962)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
T0895Sigma-AldrichThymineBioReagent, suitable for cell culture361.6元/5 g;   1250.91元/25 g;   咨询

基本信息

经验(实验)分子式C5H6N2O2
分子量126.11
Beilstein117880
EC 号200-616-1
MDL编号MFCD00006026
PubChem化学物质编号24899920
NACRESNA.75

产品性质

质量水平200
生物来源synthetic
产品线BioReagent
测定≥99% (HPLC)
形式powder
technique(s)cell culture | mammalian: suitable
mp~320 ℃ (dec.) (lit.)
溶解性1 M NaOH: 50 mg/mL, clear to hazy, colorless to faintly yellow
web metadata keyword.defaultnucleobase, pyrimidine, 5-FU analogue, thymidine precursor
SMILES stringCC1=CNC(=O)NC1=O
InChI1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
InChI keyRWQNBRDOKXIBIV-UHFFFAOYSA-N
Gene Informationmouse ... Tymp(72962)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
V900437Sigma-AldrichThymineVetec, reagent grade, 99%218.51元/25 G;   咨询

产品说明

包装

25 g in poly bottle

法律信息

Vetec is a trademark of sigma-aldrich International GmbH

基本信息

经验(实验)分子式C5H6N2O2
分子量126.11
Beilstein117880
EC 号200-616-1
MDL编号MFCD00006026
PubChem化学物质编号329829843

产品性质

等级reagent grade
产品线Vetec
测定99%
mp~320 ℃ (dec.) (lit.)
SMILES stringCC1=CNC(=O)NC1=O
InChI1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
InChI keyRWQNBRDOKXIBIV-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
PHR1345SupelcoThymine(Zidovudine Related Compound C)Pharmaceutical Secondary Standard; Certified Reference Material1769.16元/250 MG;   咨询

产品说明

一般描述

Thymine (Zidovudine Related Compound C) is a process related impurity of antiretroviral drug zidovudine. Zidovudine belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors and is generally used in the prevention and treatment of HIV/AIDS.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Thymine (Zidovudine Related Compound C) may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA1097 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C5H6N2O2
分子量126.11
Beilstein117880
EC 号200-616-1
MDL编号MFCD00006026
PubChem化学物质编号329823330
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp~320 ℃ (dec.) (lit.)
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to USP 1754532
储存温度2-30℃
SMILES stringCC1=CNC(=O)NC1=O
InChI1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
InChI keyRWQNBRDOKXIBIV-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
036430Fluorochem5-Methyluracil97%264元/25g;   550元/100g;   咨询

基本信息

CAS Number65-71-4
MDL NumberMFCD00006026
Melting Point316-317℃

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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