CAS 64984-31-2; 抑制剂-μ; pifithrin-μ

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货号

品牌

产品名称

规格

包装、参考价格

P868363

MACKLIN

抑制剂-μ

≥98%

871元/10mg; 1236元/25mg; 2935元/100mg; 5866元/250mg;

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储存：2-8°C

P2048

TCI

Pifithrin-μ

>98.0%(HPLC)(N)

750元/10MG; 4610元/100MG;

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基本信息

纯度/分析方法	>98.0%(HPLC)(N)
分子式/分子量	C₈H₇NO₂S = 181.21
外观与形状(20℃)	固体
储存温度	0-10℃
应避免的情况	加热
Reaxys-RN	2831436
PubChem物质ID	253659832
MDL编号	MFCD00181531

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 98.0 %
Melting point	135.0 to 139.0 ℃

物性(参考值)

熔点

137 ℃

安全信息

图形或危害标志
信号词	警告
危险性说明	H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
防范说明	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。

P0122

Sigma-Aldrich

Pifithrin-μ

≥97% (HPLC), solid

1255.34元/5 MG; 1827.35元/10 MG;

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产品说明

应用

菲丝菌素-μ 已用于:

处理小胶质细胞系以分析其对M1样和M2样表型的神经保护作用
作为热休克蛋白(HSP)-70抑制剂用于处理转染的Marc-145细胞
抑制热休克相关蛋白70(heat shock cognate，Hsc70)以阐明小鼠胚胎干细胞的热休克伴侣蛋白

包装

5, 10 mg in glass bottle

生化/生理作用

Pifithrin- μ是p53结合和抗凋亡的抑制剂，其可直接抑制p53与线粒体以及Bcl-xL和Bcl-2蛋白的结合。PFT μ可从致死γ -辐射诱导的细胞死亡中解救细胞。由于pifithrin- μ仅关闭p53-线粒体途径而不影响p53的转录功能，所以它比pifithrin-α 具有更优的性能。
在缺氧缺血(HI)诱发的新生儿脑病的临床前模型中，菲丝菌素μ(PFT-μ)具有防止细胞死亡的神经保护能力。它通过抑制分子伴侣热休克蛋白(HSP)-70与其底物的相互作用来抑制核因子ΙB(NF-ΙB)通路。

基本信息

经验(实验)分子式	C₈H₇NO₂S
分子量	181.21
MDL编号	MFCD00181531
PubChem化学物质编号	24724568
NACRES	NA.77

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
储存条件	desiccated
溶解性	DMSO: soluble >10 mg/mL, clear H₂O: insoluble
储存温度	2-8℃
SMILES string	NS(=O)(=O)C#Cc1ccccc1
InChI	1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChI key	ZZUZYEMRHCMVTB-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

506155

Sigma-Aldrich

Pifithrin-μ-CAS 64984-31-2-Calbiochem

1903.37元/10 MG;

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产品说明

一般描述

A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
p53 interaction with Bcl-xL and Bcl-2 proteins
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Leu, J., et al. 2009. Mol. Cell36, 15.
Strom, E., et al. 2006. Nat. Chem. Biol.2, 474.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₈H₇NO₂S
分子量	181.21
MDL编号	MFCD00181531

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	off-white
溶解性	DMSO: 50 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChI key	ZZUZYEMRHCMVTB-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

369943

Fluorochem

2-phenylacetylenesulfonamide

>98.0%(HPLC)(N)

11242元/1g;

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基本信息

CAS Number	64984-31-2
MDL Number	MFCD00181531
Melting Point	137℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .