CAS 646995-35-9; cinaciguat hydrochloride - �뵺�羺�ٷ��ַ

CAS:

646995-35-9

分子式:

C₃₆H₄₀ClNO₅

分子量:

602.16

英文名称:

cinaciguat hydrochloride

bay582667 hydrochloride

4-[[(4-carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid hydrochloride

4-[((4-carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid hydrochloride

bay 58-2667 hydrochloride

unii-59k0y58uad hydrochloride

用途:

Cinaciguat hydrochloride 是一种有效的可溶性鸟苷酸环化酶 (GC) 活化剂，在血小板中 EC50 值为 15 nM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

C878001

MACKLIN

Cinaciguat hydrochloride

≥99%

1191元/2mg; 2083元/5mg;

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储存：2-8℃

SML1532

Sigma-Aldrich

Cinaciguat hydrochloride

≥98% (HPLC)

2532.84元/5 MG; 10154.5元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.
Cinaciguat, also known as BAY 58-2667, is a novel activator of guanylate cyclase. It is used in the treatment of acute decompensated heart failure (ADHF). It has been reported that cinaciguat possesses cardiovascular effects.

基本信息

经验(实验)分子式	C₃₆H₃₉NO₅ · HCl
分子量	602.16
MDL编号	MFCD28127267
PubChem化学物质编号	329825948
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	−20℃
SMILES string	OC(C(C=C1)=CC=C1CN(CCCCC(O)=O)CCC2=CC=CC=C2OCC3=CC=C(CCC4=CC=CC=C4)C=C3)=O.[H]Cl
InChI	1S/C36H39NO5.ClH/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28;/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41);1H
InChI key	LLHMBJOVHATVSP-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable