CAS 642008-81-9; brd6989 - �뵺�羺�ٷ��ַ

位置：首页 > 资料中心 > 化工字典 > 642008-81-9

CAS:

642008-81-9

分子式:

C₁₆H₁₆N₄

分子量:

264.325

英文名称:

brd6989

2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile

2-amino-3-cyano-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

A974492

MACKLIN

2-氨基-6-甲基-4-(吡啶-3-基)-5,6,7,8-四氢喹啉-3-甲腈

98%

989元/100mg; 2141元/250mg; 8050元/1g;

咨询

储存：2-8°C, 避光, 惰性气体

SML2208

Sigma-Aldrich

BRD6989

≥98% (HPLC)

859.32元/5 MG; 3469.64元/25 MG;

咨询

产品说明

生化/生理作用

BRD6989 is an inhibitor of cyclin-dependent kinase 8 (CDK8) that upregulates production of interleukin-10 (IL-10). BRD6989 was shown to bind cyclin C–CDK8 complex selectively with an IC50 value ∼200 nM and to inhibit the kinase activity of recombinant cyclin C–CDK8 or cyclin C–CDK19 complexes with IC50 values ∼500 nM and >30 μM, respectively. It enhanced the production interleukin-10 (IL-10) enhances IL-10 production in activated human and murine macrophages and dendritic cells with an EC50 value ∼1 μM.

基本信息

经验(实验)分子式	C₁₆H₁₆N₄
分子量	264.33
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	NC1=NC(CCC(C)C2)=C2C(C3=CN=CC=C3)=C1C#N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9