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关键词:       仅模糊查询
CAS: 61718-82-9
分子式: C19H25F3N2O6
分子量: 434.41
熔点: 120-121.5 °C
中文名称: 
马来酸氟伏沙明
英文名称: 
1-pentanone, 5-methoxy-1-(4-(trifluoromethyl)phenyl)-, o-(2-aminoethyl)oxime, (
5-methoxy-4'-trifluoromethylvalerophenone (e)-o-2-aminoethyloxime monomaleate
du 23000
faverin 50
fluvoxamine maleate
luvox
用途: 1.抑郁症及相关症状的治疗 ;2.强迫症症状的治疗
推荐供应商
货号品牌产品名称规格包装、参考价格
F793981MACKLIN马来酸氟伏沙明10mM in DMSO634元/1ml;   咨询
储存：-20°C
F822304MACKLIN马来酸氟伏沙明98%49元/250mg;   93元/1g;   270元/5g;   905元/25g;   2685元/100g;   9721元/500g;   咨询
储存：2~8°C
状态：白色或灰白色粉末
F0858TCIFluvoxamine Maleate>98.0%(T)(HPLC)590元/1G;   1990元/5G;   咨询

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C15H21F3N2O2・C4H4O4 = 434.41
外观与形状(20℃)固体
储存温度0-10℃
应避免的情况加热
相关CAS RN54739-18-3
Reaxys-RN6950808
PubChem物质ID160871270
Merck Index (14)4219
MDL编号MFCD00269809

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Nonaqueous Titration)min. 98.0 %
Melting point120.0 to 124.0 ℃

物性(参考值)

熔点122 ℃
水溶性实际上不溶
溶解性(易溶于)乙醇,氯仿
溶解性(可溶于)甲醇
溶解性(不溶于)乙醚

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。

相关法规

RTECS#SA9230000
360854J&KFluvoxamine Maleate98%, 一种选择性5-羟色胺再摄取抑制剂(SSRI)561元/1G;   1891元/5G;   咨询

基本信息

分子式C15H21F3N2O2·C4H4O4
分子量434.41
熔点120-124
MDL编码MFCD00269809
Beilstein6950808
Merck14,4219
存储条件Freezer -20℃

产品描述

Fluvoxamine maleate是一种选择性5-羟色胺再摄取抑制剂(SSRI)。

靶点（IC50 & Targe）

5-HT

体外研究

Fluvoxamine增加大鼠前额皮质和丘脑中[5-HT]的水平，也增加纹状体中DA的水平。[1] Fluvoxamine maleate可通过脊柱5-HT 2A/2C受体改善触觉异常性疼痛，通过作用于受体或5-HT的神经元起作用。[2]

体内研究

在非结扎小鼠的爪压力测试中，Fluvoxamine maleate也表现出剂量依赖方式的抗伤害感受。Fluvoxamine maleate也诱导急性爪压力测试的抗伤害作用，并且这种作用为5-HT3受体拮抗剂granisetron所拮抗。[2] 在大鼠海马内侧前额叶皮质（mPFC）中，Fluvoxamine（10和30 mg/kg，腹腔注射）以剂量依赖的方式增强了海马-mPFC通路突触效能。[3] 在麻醉大鼠的海马CA1区中，Fluvoxamine（10和30 毫克/千克，腹腔注射）抑制长时程增强（LTP）。Fluvoxamine（30 毫克/千克，腹腔注射）诱导的LTP为5-HT（1A）受体拮抗剂NAN-190（0.5 毫克/千克，腹腔注射）完全逆转，但不是受5-HT（4）受体拮抗剂GR113808（20 毫克/大鼠，脑室注射）以及5-HT的（7）受体拮抗剂DR4004（10 毫克/大鼠，脑室注射）所影响。[4] Fluvoxamine maleate强化了孵育在Krebs-Henseleit溶液分离的大鼠输精管对去甲肾上腺素的响应。Fluvoxamine maleate和Fluoxetine盐酸抑制钾离子对离体大鼠子宫制剂收缩的诱导作用，IC50分别为3.99μM和18.2μM。[5]

参考文献

1] Denys D, et al. Psychopharmacology (Berl),?004, 176(2), 195-203.?

[2] Honda M, et al. Neuropharmacology,?006, 51(4), 866-872.

[3] Ohashi S, et al. Brain Res,?002, 949(1-2), 131-138.

[4] Kojima T, et al. Brain Res,?003, 959(1), 165-168.

[5] Velasco A, et al. Gen Pharmacol,?997, 28(4), 509-512.

安全信息

图形或危害标志
提示语Warning
危险说明H302
防范说明P264
P270
P301+P312+P330
P501
WGK3
RTECSSA9230000
C46235Alfa AesarFluvoxamine Maleate1336元/1g;   5063元/5g;   咨询

基本信息

Ref#
46235

分子式
C15H21F3N2O2.C4H4O4

GHS危害和防范说明

GHS符号

Hazard Statements
H302
Harmful if swallowed.

Precautionary Statements
P301+P330+P331 P312 P264

Y0000854Fluvoxamine MaleateEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H21F3N2O2 · C4H4O4
分子量434.41
MDL编号MFCD00269809
PubChem化学物质编号329831192
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCOCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O
InChI1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
InChI keyLFMYNZPAVPMEGP-PIDGMYBPSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0000853Fluvoxamine for system suitabilityEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   咨询

产品说明

一般描述

本产品按照发行药典的发行和规定提供。支持本产品的所有信息，包括安全数据表和任何产品信息传单，都是在发行药典的授权下开发和发布的。 如需进一步信息和支持，请访问现行药典网站。

包装

单位数量：1 mg。可进行调整。本品按药典规定提供。有关当前单位数量，请访问 EDQM参考物质目录。

注意

请参见 由EDQM提供的SDS。。

其他说明

可能适用相应的销售限制。

基本信息

经验(实验)分子式C15H21F3N2O2 · C4H4O4
分子量434.41
MDL编号MFCD00269809
PubChem化学物质编号329831191
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCOCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O
InChI1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
InChI keyLFMYNZPAVPMEGP-PIDGMYBPSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
F2802Sigma-AldrichFluvoxamine Maleatesolid1158.6元/10 MG;   4094.18元/50 MG;   咨询

产品说明

应用

马来酸氟伏沙明已被用作测试化合物用于测定溶解度和有效血脑屏障通透性。(2)

包装

10 mg in glass bottle
50 mg in poly bottle

生化/生理作用

马来酸氟伏沙明是一种选择性的神经元5-羟色胺再摄取抑制剂。它可发挥抗抑郁和抗强迫症药物的作用。它可用于治疗强迫症和惊恐障碍。

特点和优势

该化合物出现在受体分类和信号转导手册的生物胺转运体页。想要浏览手册的其他页面，请点击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
该化合物由Solvay开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

基本信息

经验(实验)分子式C15H21F3N2O2 · C4H4O4
分子量434.41
MDL编号MFCD00269809
PubChem化学物质编号24278162
NACRESNA.77

产品性质

质量水平200
形式solid
溶解性H2O: soluble
创始人Solvay
储存温度2-8℃
SMILES stringCOCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O
InChI1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
InChI keyLFMYNZPAVPMEGP-PIDGMYBPSA-N
Gene Informationhuman ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
BP600Fluvoxamine MaleateBritish Pharmacopoeia (BP) Reference Standard1861.35元/100 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H21F3N2O2 · C4H4O4
分子量434.41
MDL编号MFCD00269809
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringCOCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O
InChI1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
InChI keyLFMYNZPAVPMEGP-PIDGMYBPSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHR1793SupelcoFluvoxamine MaleatePharmaceutical Secondary Standard; Certified Reference Material7376.63元/500 MG;   咨询

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA8815 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C15H21F3N2O2 · C4H4O4
分子量434.41
MDL编号MFCD00269809
PubChem化学物质编号329823617
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
形式solid
CofAcurrent certificate can be downloaded
包装pkg of 500 mg
application(s)pharmaceutical (small molecule)
药典可追溯性traceable to BP 600
traceable to PhEur Y0000854
traceable to USP 1285909
储存温度2-30℃
SMILES stringCOCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O
InChI1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
InChI keyLFMYNZPAVPMEGP-PIDGMYBPSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1285909USPFluvoxamine MaleateUnited States Pharmacopeia (USP) Reference Standard8840.83元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C15H21F3N2O2 · C4H4O4
分子量434.41
MDL编号MFCD00269809
PubChem化学物质编号329749904
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCOCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O
InChI1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
InChI keyLFMYNZPAVPMEGP-PIDGMYBPSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP671Fluvoxamine maleate impurity standardBritish Pharmacopoeia (BP) Reference Standard2217.2元/100 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H21F3N2O2 · C4H4O4
分子量434.41
MDL编号MFCD00269809

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式mixture
储存温度2-8℃
SMILES stringCOCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O
InChI1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
InChI keyLFMYNZPAVPMEGP-PIDGMYBPSA-N
Gene Informationhuman ... SLC6A4(6532)

安全信息

象形图GHS07
警示用语：Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 + P330 - P501
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
358115Fluorochem(2-aminoethoxy)({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene})amine; but-2-enedioic acid98%1100元/10mg;   4048元/50mg;   咨询

基本信息

CAS Number61718-82-9
MDL NumberMFCD00269809
Melting Point122℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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