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CAS: 599-79-1
分子式: C18H14N4O5S
分子量: 398.39
熔点: 260-265℃
中文名称: 
柳氮磺胺吡啶
硫氮磺吡啶
水杨酸偶氮磺胺吡啶
磺胺偶氮吡啶
柳氮吡啶
柳氮磺吡啶
英文名称: 
5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid
Salicylazosulfa pyridine
5-((p-(2-pyridylsulfamoyl)phenyl)azo)-salicylic aci
2-hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid
4-(pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene
5-(4-(2-pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid
5-(p-(2-pyridylsulfamoyl)phenylazo)salicylic acid
5-(p-(2-pyridylsulfamyl)phenylazo)salicylic acid
accucol
asulfidine
azopyrin
azopyrine
azosulfidin
azulfidine
2-hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)-benzoic aci
2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]-benzoic aci
benzosulfa
colo-pleon
reupirin
rorasul
s.a.s.-500
salazopyridin
salazopyrin
salazosulfapyridin
salazosulfapyridine
salicylazosulfapyridine
salisulf
sas-500
sasp
si-88
sulcolon
sulfasalazin
sulfasalazine
sulphasalazine
w-t sasp oral
展开更多英文名
性质描述: 其外观为棕黄色微细结晶,无臭。微溶于乙醇,不溶于水、氯仿、乙醚、苯。
生产方法: 2-氨基吡啶与N-乙酰氨基-苯磺酰氯反应,随后水解得到磺酰吡啶胺,即磺胺吡啶,磺胺吡啶重氮化后与水杨酸偶合、酸化即制得柳氮磺胺吡啶。
用途: 肠道磺胺药,与结缔组织有特殊的亲和力,系目前治疗慢性溃疡结膜炎较好的药物。
推荐供应商
货号品牌产品名称规格包装、参考价格
S838221MACKLIN柳氮磺胺吡啶BioChemika, ≥96.0%(TLC)37元/5g;   95元/25g;   335元/100g;   1168元/500g;   咨询
储存:室温
状态:黄色到棕色粉末
S795437MACKLIN柳氮磺胺吡啶10mM in DMSO428元/1ml;   咨询
储存:-20°C
S0580TCISulfasalazine>95.0%(T)(HPLC)970元/25G;   咨询

基本信息

纯度/分析方法>95.0%(T)(HPLC)
分子式/分子量C18H14N4O5S = 398.39
外观与形状(20℃)固体
应避免的情况
Reaxys-RN356241
PubChem物质ID87560165
Merck Index (14)8942
MDL编号MFCD00057363

技术规格

AppearanceLight yellow to Amber to Dark green powder to crystal
Purity(HPLC)min. 95.0 area%
Purity(Neutralization titration)min. 95.0 %

物性(参考值)

熔点246 ℃(dec.)
水溶性不溶
溶解性(微溶于)
溶解性(不溶于)乙醚,苯,氯仿

安全信息

图形或危害标志
信号词警告
危险性说明H351 : 怀疑致癌。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑:求医/就诊。
P405 : 存放处须加锁。

相关法规

RTECS#VO6250000
204189J&KSulfasalazine95%, 抗炎剂333元/1G;   765元/5G;   咨询

基本信息

分子式C18H14N4O5S
分子量398.39
熔点246
MDL编码MFCD00057363
Beilstein356241
Merck14,8942
EINECS 编号209-974-3
存储条件Freezer -20℃

安全信息

图形或危害标志
提示语Warning
危险说明H302
H410
防范说明P264
P270
P273
P301+P312
P330
P391
P501
UN号码3077
危险分类9
包装等级III
WGK2
RTECSVO6250000
C46124Alfa AesarSulfasalazine97%752元/5g;   2240元/25g;   7788元/100g;   咨询

基本信息

Ref#
46124

分子式
C18H14N4O5S

分子量
505.45

GHS危害和防范说明

GHS符号

Hazard Statements
H317 H334 H351

Precautionary Statements
P302+P352 P285 P304+P341 P342+P311 P280 P308+P313

S0883Sigma-AldrichSulfasalazine97.0-101.5%1003.35元/10 G;   3163.64元/50 G;   5477.56元/100 G;   咨询

产品说明

一般描述

柳氮磺胺吡啶(SSZ)属于磺胺类药物,可代谢为5-氨基水杨酸和磺胺吡啶。SSZ是抗菌剂(磺胺吡啶)和消炎剂(水杨酸)的反应产物。
化学结构:磺胺

应用

柳氮磺胺吡啶在临床研究中用作分析标准品:

  • 研究其对多发性硬化症(MS)患者的治疗潜力。
  • 通过抑制试验动物大鼠骨关节炎进展相关的软骨退变和疼痛研究其作为抗关节炎药物的作用。

此外,还可作为分析参考标准,以通过酶联免疫吸附试验(ELISA)和荧光分光度技术量化生物样本和水样中的分析物。




有关合适仪器技术的更多信息,请参考产品的分析证书。如需进一步支持,请联系技术服务。

包装

10, 50, 100 g in glass bottle

基本信息

经验(实验)分子式C18H14N4O5S
分子量398.39
Beilstein356241
EC 号209-974-3
MDL编号MFCD00057363
PubChem化学物质编号329824182
NACRESNA.24

产品性质

质量水平200
等级analytical standard
测定98.0-101.5%
形式powder
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp260-265 ℃ (dec.) (lit.)
application(s)forensics and toxicology
pharmaceutical (small molecule)
格式neat
作用机制DNA synthesis | interferes
enzyme | inhibits
SMILES stringOC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3
InChI1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
InChI keyNCEXYHBECQHGNR-QZQOTICOSA-N
Gene Informationhuman ... ALOX5(240), PTGS1(5742), PTGS2(5743)

安全信息

象形图GHS08
警示用语:Danger
危险声明H317 - H334
预防措施声明P261 - P280 - P284 - P304 + P340 - P333 + P313 - P342 + P311
危险分类Resp. Sens. 1 - Skin Sens. 1
储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
1636005USPSulfasalazineUnited States Pharmacopeia (USP) Reference Standard2633.96元/125 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C18H14N4O5S
分子量398.39
Beilstein356241
MDL编号MFCD00057363
PubChem化学物质编号329751196
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp260-265 ℃ (dec.) (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringOC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3
InChI1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
InChI keyNCEXYHBECQHGNR-QZQOTICOSA-N
Gene Informationhuman ... ALOX5(240), PTGS1(5742), PTGS2(5743)

安全信息

象形图GHS08
警示用语:Danger
危险声明H317 - H334
预防措施声明P261 - P280 - P284 - P304 + P340 - P342 + P311
危险分类Resp. Sens. 1 - Skin Sens. 1
储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
BP779SulfasalazineBritish Pharmacopoeia (BP) Reference Standard2125.9元/250 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 250 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C18H14N4O5S
分子量398.39
Beilstein356241
MDL编号MFCD00057363
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
mp260-265 ℃ (dec.) (lit.)
格式neat
储存温度2-8℃
SMILES stringOC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3
InChI1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
InChI keyNCEXYHBECQHGNR-QZQOTICOSA-N
Gene Informationhuman ... ALOX5(240), PTGS1(5742), PTGS2(5743)

安全信息

象形图GHS08
警示用语:Danger
危险声明H317 - H334
预防措施声明P261 - P280 - P284 - P304 + P340 - P333 + P313 - P342 + P311
危险分类Resp. Sens. 1 - Skin Sens. 1
储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
358095Fluorochem2-hydroxy-5-(2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl)benzoic acid>95.0%(HPLC)(T)220元/1g;   1914元/25g;   咨询

基本信息

CAS Number599-79-1
MDL NumberMFCD00057363
Boiling Point246℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
H351: Suspected of causing cancer ..
防范说明 P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P281: Use personal protective equipment as required.
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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