CAS 59865-13-3; 环孢菌素; cyclosporin-a

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货号

品牌

产品名称

规格

包装、参考价格

C708929

MACKLIN

环胞霉素A

98.5%

54元/100mg; 96元/1g; 399元/5g; 1699元/25g; 5190元/100g;

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储存：2-8°C

C804822

MACKLIN

环胞霉素A

96%

29元/25mg; 45元/100mg; 80元/1g; 333元/5g; 1485元/25g;

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储存：2~8°C
状态：白色到浅黄色粉末

C795876

MACKLIN

环胞霉素A

10mM in DMSO

459元/1ml;

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储存：-20°C
状态：液体

182347

J&K

Cyclosporin A

99%, 免疫抑制剂

181元/100MG; 931元/1G;

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基本信息

分子式	C₆₂H₁₁₁N₁₁O₁₂
分子量	1202.61
熔点	151
比旋光度([α]20D)	-193.0° to -185.0° (C=0.5, MeOH)
MDL编码	MFCD00274558
Beilstein	3647785
Merck	14,2752
存储条件	Store at 2-8℃

安全信息

图形或危害标志
提示语	Danger
危险说明	H302 H350 H360
防范说明	P201 P308+P313
WGK	3
RTECS	GZ4120000

SML1018

Sigma-Aldrich

Cyclosporin A, Ready Made Solution

1 mg/mL in DMSO

1824.59元/1 ML;

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产品说明

应用

Cyclosporin A has been used to test its toxic effect on perfused 3D proximal tubule model.

生化/生理作用

Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes. It has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca²⁺- and calmodulin-dependent protein phosphatase,inhibiting its enzymatic activity. CsA was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes.At concentrations >10 nM, CsA protected isolated hepatocytes against the action of phalloidin.CsA can inhibit IL₂production resulting from T cell activation via Calcineurin inhibition.
An extensive list of references has been reported, including a comprehensive review of analytical properties.
Cyclosporin A is generally given subsequent to transplant surgery to prevent rejection. In addition to its beneficial effects in organ transplantation, cyclosporin (CyA) exhibits nephrotoxic side effects.

其他说明

Light sensitive

基本信息

经验(实验)分子式	C₆₂H₁₁₁N₁₁O₁₂
分子量	1202.61
EC 号	200-664-3
NACRES	NA.77

产品性质

形式	DMSO solution
质量水平	200
储存条件	protect from light
浓度	1 mg/mL in DMSO
运输	dry ice
储存温度	−20℃
InChI	1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+
InChI key	PMATZTZNYRCHOR-IMVLJIQESA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - closed cup
闪点(C)	87 ℃ - closed cup

Y0002292

Ciclosporin for system suitability A

European Pharmacopoeia (EP) Reference Standard

1654.43元/ ;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pha

生化/生理作用

具有强效免疫抑制性的真菌代谢物。它通过形成抑制钙调磷酸酶(蛋白磷酸酶 2B)的环孢菌素 A-亲环蛋白络合物来抑制 T 细胞受体信号转导通路。抑制通过白介素 1α、脂多糖和TNFα 诱导的一氧化氮合成。能够阻断细胞色素 c 从线粒体的释放。

包装

Unit quantity: 1 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₆₂H₁₁₁N₁₁O₁₂
分子量	1202.61
Beilstein	3647785
MDL编号	MFCD00274558

产品性质

manufacturer/tradename	EDQM
储存温度	2-8℃
SMILES string	CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InChI	1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
InChI key	PMATZTZNYRCHOR-CGLBZJNRSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H350 - H360FD
预防措施声明	P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
危险分类	Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3