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CAS: 58-39-9
分子式: C21H26ClN3OS
分子量: 403.97
中文名称: 
羟哌氯丙嗪
过非那嗪
英文名称: 
Triafon
4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazineethano
1',1-(2-idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina
1-(2-hydroxyethyl)-4-(3-(2-chloro-10-phenothiazinyl)propyl)piperazine
4(3-(2-chloro-10h-phenothiazin-10-yl)propyl)-1-piperazineethano
4-[3-(2-chloro-10h-phenothiazin-10yl)propyl]-1-piperazineethano
2-chloro-10-3-(1-(2-hydroxyethyl)-4-piperazinyl)propyl phenothiazine
2-chloro-10-[3-[1-(2-hydroxyethyl)-4-piperazinyl]propyl]phenothiazine
4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazineethanol
4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol
chlorperphenazine
chlorpiprazine
decentan
emesinal
etaperazin
etaperazine
ethaperazine
fentazin
gamma-(4-(beta-hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine
perfenazina
perfenazine
perphenan
perphenazin
perphenazine
pzc
sch 3940
thilatazin
tranquisan
trifaron
trilafon
trilifan
triphenot
展开更多英文名
性质描述: 白色或类白色结晶性粉末。熔点94-100℃;沸点278-281℃(0.133kPa),214-218℃(0.02kPa)。极易溶于氯仿,溶于乙醇(153mg/ml)、丙酮(82mg/ml),几乎不溶于水。对光敏感,几乎无臭,味微苦。
生产方法: N-(2-羟乙基)哌嗪与1,3-溴氯丙烷缩合得到1-(3-氯丙基)-4-(2-羟乙基)哌嗪。然后,将其与2-氯吩噻嗪缩合,制得奋乃静粗品。用乙酸乙酯重结晶,即得成品。
用途: 该品作用与氯丙嗪相似,具有抗精神病、降低体温、止吐和镇静等作用。适用于各类型的精神分裂症,对幻觉、妄想、焦虑、紧张和激动症状有效。亦可用于恶心、呕吐、呃逆及由焦虑、激动引起的失眠等。
推荐供应商
货号品牌产品名称规格包装、参考价格
P1970TCIPerphenazine>97.0%(T)(HPLC)1095元/5G;   3860元/25G;   咨询

基本信息

纯度/分析方法>97.0%(T)(HPLC)
分子式/分子量C21H26ClN3OS = 403.97
外观与形状(20℃)固体
储存温度0-10℃
应避免的情况光,加热
Reaxys-RN54730
PubChem物质ID253660321
Merck Index (14)7183
MDL编号MFCD00056798

技术规格

AppearanceWhite to Orange to Green powder to crystal
Purity(HPLC)min. 97.0 area%
Purity(Nonaqueous Titration)min. 97.0 %
Melting point95.0 to 99.0 ℃

物性(参考值)

熔点97 ℃
水溶性不溶
在水中的溶解度28.3 mg/l   24 ℃
溶解性(易溶于)氯仿
溶解性(可溶于)丙酮,乙醇
溶解度(极微溶)乙醚

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H413 : 可能对水生生物造成长期持续有害影响。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P273 : 避免释放到环境中。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#TL7175000
207906J&KPerphenazine99%212元/1G;   773元/5G;   2424元/25G;   咨询

基本信息

分子式C21H26ClN3OS
分子量403.97
MDL编码MFCD00056798
存储条件Store at 2-8℃

安全信息

图形或危害标志
提示语Warning
危险说明H302
H317
防范说明P280
WGK3
C46849Alfa AesarPerphenazine1361元/1g;   2883元/5g;   8550元/25g;   咨询

基本信息

分子式
C21 H26 Cl N3 O S

分子量
403.98

P6402Sigma-AldrichPerphenazine1119.63元/1 G;   1642.3元/5 G;   咨询

产品说明

一般描述

Perphenazine is an antipsychotic drug used in treating schizophrenia. It modulates antioxidant levels and helps in the management of oxidative injury in schizophrenia. However, it is less effective than the clozapine drug group in improving response to oxidative injury.

包装

1, 5 g in glass bottle

生化/生理作用

D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

特点和优势

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P6402.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

基本信息

经验(实验)分子式C21H26ClN3OS
分子量403.97
EC 号200-381-5
MDL编号MFCD00056798
PubChem化学物质编号24278642
NACRESNA.77

产品性质

质量水平200
创始人Schering Plough
储存温度2-8℃
SMILES stringClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
InChI1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChI keyRGCVKNLCSQQDEP-UHFFFAOYSA-N
Gene Informationhuman ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), OPRS1(10280)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H317
预防措施声明P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352
危险分类Acute Tox. 4 Oral - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
P0550000PerphenazineEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C21H26ClN3OS
分子量403.97
MDL编号MFCD00056798
PubChem化学物质编号329820043
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
InChI1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChI keyRGCVKNLCSQQDEP-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H317
预防措施声明P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352
危险分类Acute Tox. 4 Oral - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
Y0001045Perphenazine for system suitabilityEuropean Pharmacopoeia (EP) Reference Standard1259.15元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

包装

Unit quantity: 5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C21H26ClN3OS
分子量403.97
MDL编号MFCD00056798
PubChem化学物质编号329831236
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
InChI1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChI keyRGCVKNLCSQQDEP-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H317
预防措施声明P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352
危险分类Acute Tox. 4 Oral - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHR3079SupelcoPerphenazinepharmaceutical secondary standard, certified reference material3006.17元/500 mg;   咨询

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

生化/生理作用

D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC7546 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C21H26ClN3OS
分子量403.97
MDL编号MFCD00056798

产品性质

等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 500 mg
application(s)pharmaceutical
药典可追溯性traceable to USP 1511000
储存温度2-30℃
SMILES stringClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
InChI1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChI keyRGCVKNLCSQQDEP-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H317
预防措施声明P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352
危险分类Acute Tox. 4 Oral - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP422PerphenazineBritish Pharmacopoeia (BP) Reference Standard1861.35元/100 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C21H26ClN3OS
分子量403.97
EC 号200-381-5
MDL编号MFCD00056798
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
SMILES stringClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
InChI1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChI keyRGCVKNLCSQQDEP-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H317
预防措施声明P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352
危险分类Acute Tox. 4 Oral - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1511000USPPerphenazineUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C21H26ClN3OS
分子量403.97
MDL编号MFCD00056798
PubChem化学物质编号329750721
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
InChI1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChI keyRGCVKNLCSQQDEP-UHFFFAOYSA-N
Gene Informationhuman ... DRD2(1813)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H317
预防措施声明P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352
危险分类Acute Tox. 4 Oral - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
094523Fluorochem2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]-piperazin-1-yl]ethanol98%330元/1g;   836元/5g;   2596元/25g;   咨询

基本信息

CAS Number58-39-9
MDL NumberMFCD00056798
Melting Point95-99℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H317: May cause an allergic skin reaction.
防范说明 P261: Avoid breathing .
P264: Wash thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P333 + P313: If skin irritation or rash occurs: Get medical advice/attention.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to local regulations..
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