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CAS: 573-58-0
分子式: C32H22N6Na2O6S2
分子量: 696.69
熔点: >360 °C(lit.)
中文名称: 
棉红
刚果红AT
4,4'-二苯基-双[1-偶氮-2)-1-氨基萘-4-二磺酸钠]
二苯基4,4'-[(偶氮-2-)-1-氨基萘-4-磺酸钠
直接大红4B
直接朱红
刚果红
直接煮红
直接大红 4B
风果红
直接刚果红
煮大红
直接大红
二苯基-4,4-二[(偶氮-2)-1-氨基萘-4-磺酸钠
展开更多中文名
英文名称: 
Congo Red,indicator grade
abcol congo red
Sodium diphenyl diazo-bis-naphthylamine-4-sulfonate
Direct red C.R.Y.
C.T.NO,22120
Sodi-um diphenyl-bis-(azo-naphthionate)
Direct scarlet 4B
C.I. Direct red 28
3,3'-(4,4'-biphenylenebis(azo))bis(4-amino-1-naphthalenesulfonic aci disodi
1-naphthalenesulfonic acid, 3,3'-((1,1'-biphenyl)-4,4'-diylbis(azo))bis(4-amino
1-naphthalenesulfonic acid, 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis[4-amino
atlantic congo red
atul congo red
azocard red congo
benzo congo red
brasilamina congo 4b
c.i. 22120
c.i. direct red 28, disodium salt
cerven kongo
cerven prima 28
congo red
congo red 4b
congo red 4bx
congo red cr
congo red h
congo red ici
congo red l
congo red m
congo red n
congo red r
congo red rs
congo red w
congo red ws
cotton red 4bc
cotton red 5b
cotton red l
diacotton congo red
direct red 28
direct red c
direct red dc-cf
direct red k
erie congo 4b
haemomedical
haemonorm
hemorrhagyl
hispamin congo 4b
kayaku congo red
kongorot
mitsui congo red
natrium-salz der diphenyl-bis-azo-bis-naphthylamin-4-sulfonsaeure
peeramine congo red
red k
sodium diphenyldiazo-bis(alpha-naphthylaminesulfonate)
sodium diphenyldiazo-bis-alpha-naphthylamine-sulfonate
solucongo
sugai congo red
tertrodirect red c
trisulfon congo red
vondacel red cl
展开更多英文名
性质描述: 棕红色粉状物,易溶于热水,溶于10份冷水,溶液呈黄红色;溶于乙醇呈橙色;极微溶于丙酮,几乎不溶于醚。溶于乙醇呈橙色,微溶于丙酮。在浓硫酸中呈深蓝色,稀释后呈浅蓝色有蓝针对沉淀。其水溶液加浓盐酸生成戏光蓝色沉淀;加乙酸生成呈蓝光紫色转为较红的蓝色沉淀。在浓烧碱中不溶解。对酸、盐敏感,即使从空气中吸收二氧化碳,也会使色泽变蓝暗,但用稀纯碱液处理可恢复原来色泽。
生产方法: 由联欢苯胺重氮化后,与1,4-氨基萘磺酸钠进行偶合,而后经盐析、过滤及干燥而制得。具体操作为:取48.4g联苯胺溶于300ml盐酸(含浓盐酸20ml)中,加冰冷至5℃以下,加30ml浓盐酸后,加入由14.4g亚硝酸钠配成的10%的水溶液。重氮化结束后,将重氮盐溶液慢慢加入150g对氨基萘磺酸钠和少量水配成的溶液中,放置半小时后,在充分搅拌下慢慢加入35g碳酸钠,使溶液呈碱性,加热至约80℃后,冷却,过滤,用饱和盐水洗涤,干燥即得成品。工业制备原料消耗(kg/t)联苯胺(100%) 200氨基萘磺酸钠(100%) 520亚硝酸钠(工业) 160盐酸(31%) 330纯碱(工业) 340精盐 2500太古油 9乙醇 60乙酸钠 35元明粉 50
用途: 曾广泛用于棉、粘胶的染色,因其遇酸极易转变为蓝色,以及无适当处理方法使之提高其湿处理牢度,故自不溶性偶氮染料和直接耐酸大红4BS问世以来,该品在染色中的使用量逐减减少,但在造纸工业中用量颇大。还可作为酸碱指标剂,即刚果红试纸,pH3.0(蓝紫)-5.0(红)。另外还用于生物染色,分析试剂。
推荐供应商
货号品牌产品名称规格包装、参考价格
C796693MACKLIN刚果红指示剂1%(w/v) in water298元/500ml;   咨询
储存:室温
状态:液体
C794461MACKLIN刚果红10mM in DMSO463元/1ml;   咨询
储存:-20°C
C799116MACKLIN刚果红指示剂级49元/100g;   235元/500g;   710元/2.5kg;   咨询
储存:室温
状态:红色到红棕色粉末
C804149MACKLIN刚果红生物染料50元/25g;   92元/100g;   339元/500g;   1258元/2.5kg;   咨询
储存:室温
状态:粉末
D6210MACKLIN刚果红 直接红 28生物技术级39元/2g;   99元/10g;   378元/50g;   1196元/250g;   3580元/1kg;   咨询
储存:室温
状态:粉末
C0550TCICongo Red>98.0%(HPLC)680元/25G;   咨询

基本信息

纯度/分析方法>98.0%(HPLC)
分子式/分子量C32H22N6Na2O6S2 = 696.66
外观与形状(20℃)固体
Reaxys-RN6765909
PubChem物质ID87565658
Merck Index (14)2498
颜色22120
MDL编号MFCD00004028

技术规格

AppearanceDark red to Brown powder to crystal
Purity(HPLC)min. 98.0 area%
Absorbancemin. 0.270(10 mg/L, pH 5.0, 488.0 to 492.0 nm)
Drying lossmax. 8.0 %
Ignition residue(Sulfate)18.0 to 40.0 %(after drying)
Transition interval(pH)(purple)2.6 to 4.0(dark redish orange)

物性(参考值)

水溶性可溶
溶解性(可溶于)乙醇

安全信息

图形或危害标志
信号词警告
危险性说明H361 : 怀疑对生育能力或胎儿造成伤害。
H351 : 怀疑致癌。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308 + P313 : 如接触到或有疑虑:求医/就诊。
P405 : 存放处须加锁。

相关法规

RTECS#QK1400000
308507J&KCongo Red, indicator指示剂136元/25G;   354元/100G;   咨询

基本信息

分子式C32H22N6Na2O6S2
分子量696.66
熔点>360
MDL编码MFCD00004028
Beilstein3894858
Merck14,2498
EINECS 编号209-358-4

安全信息

图形或危害标志
提示语Danger
危险说明H350
H361d
防范说明P201
P281
P308+P313
WGK3
RTECSQK1400000
TSCA
B24310Alfa AesarCongo Redindicator grade495元/25g;   1377元/100g;   5199元/500g;   咨询

应用
Congo red is useful for staining and visual detection of amyloid deposits. It inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the metabolism of the normal isoform.

备注
Store away from oxidizing agents, acids, reducing agents.

基本信息

MDL
MFCD00004028

EINECS
209-358-4

分子式
C32H22N6Na2O6S2

分子量
696.67

熔点
>360°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water 25 g/L.

Beilstein
3894858

Merck
14,2498

GHS危害和防范说明

GHS符号

Hazard Statements
H350-H361
May cause cancer.Suspected of damaging fertility or the unborn child.

Precautionary Statements
P201-P280-P202-P308+P313-P405-P501a
Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Do not handle until all safety precautions have been read and understood.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
45-63
May cause cancer.Possible risk of harm to the unborn child.

安全等级
53-45
Avoid exposure - obtain special instructions before use.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

RTECS
QK1400000

TSCA

C58025Alfa AesarCONGO RED CERTIF BIO STAIN 25G372元/25g;   咨询

基本信息

Ref#
F54449

R11152Alfa AesarDirect Red 28 Standard solution100ppm419元/1ml;   咨询
R12142Alfa AesarDirect Red 28,1000ppm704元/1ml;   咨询
1.01340SupelcoCongo red (C.I. 22120)indicator Reag. Ph Eur851.57元/25 G;   咨询

产品说明

分析说明

Appearance: Red-brown to brownishred powder, eventually with granular parts.
Appearance of solution (1.0 gr/l; water): Almost clear to slightly turbid, red
Transition range: pH 3.0 - pH 5.2violet - orange-red
Loss on drying (110 °C): ≤ 5 %
Sensitivity test: passes test

基本信息

经验(实验)分子式C32H22N6Na2O6S2
分子量696.66
MDL编号MFCD00004028
EC索引号209-358-4

产品性质

agencyreag. Ph. Eur.
质量水平200
蒸汽压<1 Pa
效能143 mg/kg LD50, oral (Rat)
缺失≤5% loss on drying, 110℃
pH值(酸碱度)6.7 (20 ℃, 10 g/L in H2O)
mp>360 ℃
堆积密度600‑700 kg/m3
储存温度2-30℃
InChI1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2
InChI keyIQFVPQOLBLOTPF-UHFFFAOYSA-L

安全信息

象形图GHS08
警示用语:Danger
危险声明H350 - H361d
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Carc. 1B - Repr. 2
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
C6767Sigma-AldrichCongo RedDye content ≥35 %290.41元/25 G;   762.04元/100 G;   咨询

产品说明

应用

  • 刚果红已被用作定量脑组织中淀粉样沉积物的组织化学染色。
  • 它已被用作真菌新隐球菌的细胞壁抑制剂。
  • 它也被用来研究生马铃薯和油炸马铃薯细胞壁的显微结构细节。

包装

25, 100 g in poly bottle

生化/生理作用

刚果红是一种联苯胺基阴离子重氮染料。它是一种与许多淀粉样蛋白结合的组织学染料,用于淀粉样蛋白& # 946;肽聚集的定量。刚果红也可与& # 946;-右旋葡聚糖,以及含有连续& # 946;-(1 & # 8594;4)-连接的D-吡喃葡萄糖基单元和一些半纤维素半乳甘露聚糖反应。

基本信息

经验(实验)分子式C32H22N6Na2O6S2
分子量696.66
颜色索引号22120
Beilstein3894858
EC 号209-358-4
MDL编号MFCD00004028
PubChem化学物质编号24892892
NACRESNA.47

产品性质

形式powder
质量水平200
组成Dye content, ≥35%
technique(s)titration: suitable
pH值(酸碱度)6.7 (10 g/L)
mp>360 ℃ (lit.)
溶解性H2O: 1 mg/mL
application(s)diagnostic assay manufacturing
hematology
histology
储存温度room temp
SMILES string[Na+].[Na+].Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c3ccc(cc3)-c4ccc(cc4)\N=N\c5cc(c6ccccc6c5N)S([O-])(=O)=O
InChI1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/b37-35+,38-36+;;
InChI keyIQFVPQOLBLOTPF-HKXUKFGYSA-L

安全信息

象形图GHS08
警示用语:Danger
危险声明H350 - H361d
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Carc. 1B - Repr. 2
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
个人防护装备Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
C6277Sigma-AldrichCongo Redcertified by the Biological Stain Commission, BioXtra2315.81元/25 G;   咨询

产品说明

应用

刚果红已可用于β淀粉样肽的染色。

包装

25 g in glass bottle

生化/生理作用

刚果红是一种基于联苯胺的阴离子重氮染料。它是一种组织学染料,可与多种淀粉样蛋白结合,用于定量淀粉样蛋白β-肽聚集。刚果红还能与β-D-葡聚糖、含有连续β-(1→4)-键的D-吡喃葡萄糖基单元的多糖以及一些半纤维素半乳糖甘露聚糖发生相互作用。

适用性

经认证可用作明矾苏木精的复染剂,以及用于Puchtler淀粉样蛋白染色的Highman或Churukian修饰。

基本信息

经验(实验)分子式C32H22N6Na2O6S2
分子量696.66
颜色索引号22120
Beilstein3894858
EC 号209-358-4
MDL编号MFCD00004028
PubChem化学物质编号24892852

产品性质

质量水平200
等级certified by the Biological Stain Commission
产品线BioXtra
形式powder
组成Dye content, ≥85%
mp>360 ℃ (lit.)
溶解性H2O: 10 mg/mL
application(s)diagnostic assay manufacturing
hematology
histology
储存温度room temp
SMILES string[Na+].[Na+].Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c3ccc(cc3)-c4ccc(cc4)\N=N\c5cc(c6ccccc6c5N)S([O-])(=O)=O
InChI1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/b37-35+,38-36+;;
InChI keyIQFVPQOLBLOTPF-HKXUKFGYSA-L

安全信息

象形图GHS08
警示用语:Danger
危险声明H350 - H361d
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Carc. 1B - Repr. 2
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
个人防护装备Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
75768SupelcoCongo Redanalytical standard1343.24元/25 MG;   咨询

产品说明

应用

关于适当仪器技术的更多信息,请参见产品的检验报告。联系技术服务部寻求进一步支持。

包装

无底玻璃瓶。内容物在插入的熔锥内。

基本信息

经验(实验)分子式C32H22N6Na2O6S2
分子量696.66
颜色索引号22120
Beilstein3894858
EC 号209-358-4
MDL编号MFCD00004028
PubChem化学物质编号329766696
NACRESNA.24

产品性质

等级analytical standard
质量水平100
测定≥97.0% (HPLC)
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp>360 ℃ (lit.)
application(s)cleaning products
cosmetics
environmental
food and beverages
personal care
格式neat
SMILES string[Na+].[Na+].Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c3ccc(cc3)-c4ccc(cc4)\N=N\c5cc(c6ccccc6c5N)S([O-])(=O)=O
InChI1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/b37-35+,38-36+;;
InChI keyIQFVPQOLBLOTPF-HKXUKFGYSA-L

安全信息

象形图GHS08
警示用语:Danger
危险声明H350 - H361d
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Carc. 1B - Repr. 2
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
个人防护装备Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
234610Sigma-AldrichCongo Red, High Purity-CAS 573-58-0-CalbiochemAn amyloidophylic dye that specifically stains stacked β sheet aggregates.1272.64元/500 MG;   咨询

产品说明

一般描述

An amyloidophylic dye that specifically stains stacked β sheet aggregates. Useful for staining and visual detection of amyloid deposits. Does not bind to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the metabolism of the normal isoform. It is also shown to inhibit Pot1 Binding to Telomeric DNA.
An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.

包装

500 mg in Glass bottle

生化/生理作用

Primary Target
An amyloidophylic dye that specifically stains stacked β sheet aggregates
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).

其他说明

Altschuler, S.E., et al. 2012. Biochemistrin press.
Khurana, R., et al. 2001. J. Biol. Chem.276, 22715.
Fezoui, Y., et al. 2000. Amyloid7, 166.
Fezoui, Y., et al. 2000. Nat. Struct. Biol.7, 1095.
Kramport, M., et al. 2000. Chem. Biol.7, 855.
Kuner, P., et al. 2000. J. Biol. Chem.275, 1673.
Caspi, S., et al. 1998. J. Biol. Chem.273, 3484.
Caughey, B., and Race, A.E. 1992. J. Neurochem.59, 768.
Taylor, D.L., et al. 1974. J. Histochem. Cytochem.22, 1105.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C32H22N6O6S2 · 2Na
分子量696.66
MDL编号MFCD00004028

产品性质

质量水平100
测定≥75% dye basis
形式crystalline solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 rust
溶解性water: 10 mg/mL
ethanol: soluble
运输ambient
储存温度15-25℃
InChI1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2
InChI keyIQFVPQOLBLOTPF-UHFFFAOYSA-L

安全信息

象形图GHS08
警示用语:Danger
危险声明H350 - H361d
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Carc. 1B - Repr. 2
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
DYE-064S-R1AccuStandardDirect Red 28,100 μg/mL in Methanol100 μg/mL in Methanol185元/1mL;   咨询
Direct Red 28刚果红573-58-0100 µg/mL
CAS号首数字顺序排列: 1 2 3 4 5 6 7 8 9
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