CAS 5725-91-7; 7-ethoxyresorufin - �뵺�羺�ٷ��ַ

位置：首页 > 资料中心 > 化工字典 > 5725-91-7

CAS:

5725-91-7

分子式:

C14H11NO3

分子量:

241.24

熔点:

223-225℃

英文名称:

7-ethoxyresorufin

ethoxyresorufin

o(7)-ethylresorufin

用途:

7-Ethoxyresorufin is a fluorimetric substrate and suicide inhibitor of CYP (cytochrome P450). Also shown to inhibit several reductase enzymes, specifically CYPOR (NADPH-P450 reductase). The binding to CYP (cytochrome P450) is thought to inhibit the vasorelaxant response to acetylcholine. 7-Ethoxyresorufin has also demonstrated inhibition of NO synthesis by uncoupling neuronal NOS1 (nitric oxide synthase); it is a noncompetitive inhibitor of neuronal NOS1 with respect to L-arginine with a Ki value of 0.76 +/- 0.06 μM. 7-Ethoxyresorufin is a substate of CYP1A1.

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

R864269

MACKLIN

乙氧基试卤灵

≥95% (UV)

600元/5mg; 1855元/25mg; 4655元/100mg; 8997元/250mg;

咨询

储存：-20°C
状态：橙色到红色-橙色和红色粉末或晶体

934512

J&K

Resorufin ethyl ether

95%

2882元/5MG;

咨询

基本信息

分子式	C₁₄H₁₁NO₃
分子量	241.25
熔点	223-225
MDL编码	MFCD00037661
Beilstein	225973
存储条件	Freezer -20℃

安全信息

WGK	3
TSCA	否

E3763

Sigma-Aldrich

Resorufin ethyl ether

1253.81元/1 MG; 4329.56元/5 MG;

咨询

产品说明

一般描述

试卤灵(Resorufin)是刃天青的还原产物，也称为阿尔玛蓝(Alamar Blu)。它在较长的波长下发射荧光，并且其羟基可进行灵活的修饰。
试卤灵被用作不同细胞色素 P (CYP) 亚型的标记物或底物。试卤灵乙醚是 3-甲基胆蒽处理动物的微粒体代谢的首选试卤灵乙醚。

应用

试卤灵乙醚适用于研究细胞色素 P450 同工酶 1A1 和 1A2 的脱烷基活性，其中芳基烷基和烷基异硫氰酸盐及其谷胱甘肽、半胱氨酸和 A′-乙酰半胱氨酸结合物用作抑制剂。适合于研究细胞色素 P450 活性 (CYP1A1) 的乙氧基试卤灵-O-脱乙基酶 (EROD) 活性。

包装

1, 5 mg in glass bottle

底物

细胞色素 P450 连接酶 CXPIA1/2 的荧光底物

基本信息

经验(实验)分子式	C₁₄H₁₁NO₃
分子量	241.24
Beilstein	225973
MDL编号	MFCD00037661
PubChem化学物质编号	24894527
NACRES	NA.47

产品性质

测定	≥98% (TLC)
质量水平	200
形式	powder
mp	223-225 ℃ (lit.)
溶解性	chloroform: 9.80-10.20 mg/mL, clear, orange
储存温度	−20℃
SMILES string	CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F
InChI	1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3
InChI key	ZOSYTBPPLWBBKM-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

46121

Sigma-Aldrich

Resorufin ethyl ether

suitable for fluorescence, ≥95% (UV)

4209.24元/5 MG; 16836.8元/25 MG;

咨询

产品说明

应用

7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

其他说明

Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450

基本信息

经验(实验)分子式	C₁₄H₁₁NO₃
分子量	241.24
Beilstein	225973
MDL编号	MFCD00037661
PubChem化学物质编号	329757074
NACRES	NA.32

产品性质

质量水平	100
测定	≥95% (UV)
mp	223-225 ℃ (lit.)
溶解性	DMF: soluble DMSO: soluble alcohols: soluble
荧光	λ_ex 464 nm; λ_em 540 nm in methanol(lit.) λ_ex 571 nm; λ_em 585 nm in dealkylase(lit.)
适用性	suitable for fluorescence
储存温度	2-8℃
SMILES string	CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F
InChI	1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3
InChI key	ZOSYTBPPLWBBKM-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9