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CAS: 57-66-9
分子式: C13H19NO4S
分子量: 285.36
中文名称: 
对-(二丙基氨磺酸)苯甲酸
丙磺舒
羧苯磺胺
4-(二丙基氨磺酰基)苯甲酸
丙苯尼西德
羧苯磺丙胺
英文名称: 
p-(dipropylsulfamoyl)-benzoic aci
4-((dipropylamino)sulfonyl)benzoic acid
4-(dipropylsulfamoyl) benzoic acid
4-(dipropylsulfamoyl)benzoic acid
4-[(dipropylamino)sulfonyl]benzoic acid
apurina
benacen
benemid
benemide
benuryl
benzoic acid, 4-((dipropylamino)sulfonyl)
4-((dipropylamino)sulfonyl)-benzoic aci
4-[(dipropylamino)sulfonyl]-benzoic aci
col-probenecid
colbenemid
ethamide
nc1-c56097
nci-c56097
p-(dipropylsulfamoyl)benzoic acid
p-(dipropylsulfamyl)benzoic acid
polycillin-brb
probalan
probampacin
probecid
proben
probenecid
probenecid acid
probenemid
probenid
prolongine
robenecid
synergid r
tubophan
uricosid
展开更多英文名
性质描述: 白色结晶性粉末。熔点194-196℃。溶于丙酮,略溶于乙醇或氯仿,几乎不溶于水。溶于稀氢氧化钠溶液,在稀酸中几乎不溶。无臭,味微苦。
生产方法: 对甲苯磺酰胺经重铬酸钠氧化为对羧苯磺酰胺,再用溴丙烷进行烷基化反应,所得丙磺舒钠用乙酸酸化即得丙磺舒。
用途: 抗痛风药。该品为有机酸,脂溶性强,自肾小管分泌排出,又很容易被回吸收。故在丙磺郐存在下,体内某些有机酸在肾小管的运转将受到抑制,减少其他有机酸的排泄。故用于治疗慢性痛风,安全有效。对急性痛风的疼痛和炎症无作用,不适用于急性痛风。
推荐供应商
货号品牌产品名称规格包装、参考价格
B20010Alfa AesarProbenecid98%1199元/2.5g;   4106元/10g;   咨询

应用
It is a uricosuric drug, that is, it increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia. Probenecid was developed as an alternative to caronamide to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effects.

备注
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

基本信息

MDL
MFCD00038402

EINECS
200-344-3

分子式
C13H19NO4S

分子量
285.36

熔点
198-199°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water (partly miscible), solutions of alkali hydroxides,, ethanol (100 mM), acetone, chloroform, sodium hydroxide (1 M), DMSO (100 mM), methanol, dilute acids (practically insoluble), dilute alkalies, and ether (slightly soluble).

Merck
14,7754

GHS危害和防范说明

GHS符号

Hazard Statements
H301-H315-H319-H335
Toxic if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22-36/37/38
Harmful if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
26-36/37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.

欧盟危险品标志

RTECS
DG9400000

TSCA

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