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CAS: 57-41-0
分子式: C15H12N2O2
分子量: 252.27
熔点: 293.5-295℃
中文名称: 
5,5-二苯基乙内酰脲
5,5-二苯基海因
5,5-联苯基乙内酰脲
苯妥英
英文名称: 
Hydantoin,5,5-diphenyl-
5,5-Dipheny
5,5-diphenyl-Hydantoin
Aleviatin
Antisacer
Causoin
Citrullamon
Comital
Comitoina
Convul
Danten
Dantinal
Dantoinal klinos
Dantoine
Denyl
Didan-tdc-250
Difenin
Difetoin
Difhydan
Dihycon
di-Hydan
Dihydantoin
Dilabid
di-Lan
Dilantine
Dilantin
5,5-Diphenylhydantoin
5,5-Diphenylimidazolidin-2,4-dione
5,5-Diphenyl-2,4-imidazolidinedione
di-Phetine
Ditoinate
Elepsindon
5,5-diphenyl-hydantoi
5,5-dwufenylohydantoina
dantoinal
difenilhidantoina
dintoina
diphantoin
diphedan
diphenylhydantoin
diphenylhydantoine
ekko capsules
enkelfel
epamin
epdantoine simple
fenitoina
fentoin
gerot-epilan-d
hidantal
hidantilo
ictalis simple
kessodanten
lepsin
minetoin
nci-c55765
neos-hidantoina
neosidantoina
novantoina
om hidantoina simple
om-hydantoine
phentoin
phenytoin
ritmenal
silantin
sodanton
zentropil
5,5-Diphenylhydanthoin
展开更多英文名
推荐供应商
货号品牌产品名称规格包装、参考价格
D794403MACKLIN5,5-二苯基乙内酰脲标准溶液1000μg/ml, in Purge and Trap Methanol820元/1ml;   咨询
储存:-20°C
D834903MACKLIN5,5-二苯基乙内酰脲99%58元/25g;   168元/100g;   728元/500g;   咨询
储存:室温,密封,干燥
状态:白色-几乎白色晶体-粉末
D794404MACKLIN5,5-二苯基乙内酰脲10mM in DMSO431元/1ml;   咨询
储存:-20°C
D0894TCIPhenytoin>99.0%(T)215元/25G;   1990元/500G;   咨询

基本信息

纯度/分析方法>99.0%(T)
分子式/分子量C15H12N2O2 = 252.27
外观与形状(20℃)固体
Reaxys-RN384532
PubChem物质ID87567495
SDBS (AIST Spectral DB)7403
Merck Index (14)7322
MDL编号MFCD00005264

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Neutralization titration)min. 99.0 %
Solubility in Acetonealmost transparency

物性(参考值)

熔点298 ℃
水溶性不溶
溶解性(微溶于)丙酮,醇
溶解性(不溶于)乙醚,苯,氯仿

安全信息

图形或危害标志
信号词危险
危险性说明H302 : 吞咽有害。
H360 : 可能对生育能力或胎儿造成伤害。
H370 : 会损害器官。
H372 : 长期或反复接触会对器官造成损害。
H340 : 可能造成遗传性缺陷。
H351 : 怀疑致癌。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P260 : 不要吸入粉尘/ 烟/ 气体/ 烟雾/ 蒸气/ 喷雾。
P270 : 使用本产品时不要进食、饮水或吸烟。
P202 : 在阅读并明了所有安全措施前切勿搬动。
P201 : 使用前取得专用说明。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P308+P311 : 如接触到或有疑虑:呼叫急救中心/医生。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#MU1050000
A17013Alfa Aesar5,5-Diphenylhydantoin99%420元/25g;   552元/100g;   2208元/500g;   咨询

基本信息

MDL
MFCD00005264

EINECS
200-328-6

分子式
C15H12N2O2

分子量
252.27

熔点
293-298°

形态
Powder

Beilstein
384532

Merck
14,7322

GHS危害和防范说明

GHS符号

Hazard Statements
H303-H317-H350-H360
May be harmful if swallowed.May cause an allergic skin reaction.May cause cancer.May damage fertility or the unborn child.

Precautionary Statements
P201-P261-P280-P308+P313-P405-P501a
Obtain special instructions before use.Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/protective clothing/eye protection/face protection.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
45-61-22-43
May cause cancer.May cause harm to the unborn child.Harmful if swallowed.May cause sensitization by skin contact.

安全等级
53-20-24-37-45
Avoid exposure - obtain special instructions before use.When using do not eat or drink.Avoid contact with skin.Avoid contact with skin.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

RTECS
MU1050000

TSCA

C17173Alfa Aesar5,5-Diphenylhydantoin99+%446元/5g;   咨询

基本信息

Ref#
17173

MDL
5264

分子式
C15 H12 N2 O2

分子量
252.27

PHR1139SupelcoPhenytoinPharmaceutical Secondary Standard; Certified Reference Material1359.83元/1 G;   咨询

产品说明

一般描述

苯妥英是一种众所周知的芳香族抗惊厥药,它在肝微粒体系统中进行代谢。它是癫痫发作最有效的治疗方法。它属于苯基乙内酰脲类化合物。它可以通过稳定钠通道以降低细胞之间的电导率来阻止癫痫发作期间不必要的大脑活动。
用于质量控制的药物二级标准品,为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

应用

苯妥英可用作药物参考标准品,用于通过电化学、分光光度法和色谱技术测定药物制剂和组合剂型中的分析物。
这些二级标准品是合格的认证标准物质(CRM)。它们适用于多种分析应用,包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

减少癫痫大发作的发生率;可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。

分析说明

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

其他说明

分析物的数值在批次间变化很大。
本有证标准物质 (CRM) 按照 ISO 17034 ISO/IEC 17025 生产和认证。有关本 CRM 使用的所有信息,请参见检验报告。

附注

该材料的检验报告示例请在下面的插槽中输入 LRAB7779。这只是一个示例证书,可能不是您收到的批次。

基本信息

经验(实验)分子式C15H12N2O2
分子量252.27
Beilstein384532
EC 号200-328-6
MDL编号MFCD00005264
PubChem化学物质编号329823159
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp293-295 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to PhEur P1290000
traceable to USP 1535008
储存温度2-30℃
SMILES stringO=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
InChI1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
InChI keyCXOFVDLJLONNDW-UHFFFAOYSA-N
Gene Informationhuman ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H351 - H360FD
预防措施声明P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
P1290000PhenytoinEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

减少癫痫大发作的发生率;可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。

包装

Unit quantity: 120 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H12N2O2
分子量252.27
Beilstein384532
MDL编号MFCD00005264
PubChem化学物质编号329820085
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp293-295 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringO=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
InChI1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
InChI keyCXOFVDLJLONNDW-UHFFFAOYSA-N
Gene Informationhuman ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H351 - H360FD
预防措施声明P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
Y0001167Phenytoin for system suitabilityEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

减少癫痫大发作的发生率;可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H12N2O2
分子量252.27
Beilstein384532
MDL编号MFCD00005264
PubChem化学物质编号329831289
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
mp293-295 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringO=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
InChI1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
InChI keyCXOFVDLJLONNDW-UHFFFAOYSA-N
Gene Informationhuman ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H351 - H360FD
预防措施声明P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
1535008USPPhenytoinUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

减少癫痫大发作的发生率;可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C15H12N2O2
分子量252.27
Beilstein384532
MDL编号MFCD00005264
PubChem化学物质编号329750826
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp293-295 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringO=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
InChI1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
InChI keyCXOFVDLJLONNDW-UHFFFAOYSA-N
Gene Informationhuman ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H351 - H360FD
预防措施声明P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
D4007Sigma-Aldrich5,5-Diphenylhydantoin≥98%573.01元/5 G;   668.52元/100 G;   咨询

产品说明

一般描述

5,5-二苯基海因是一种抗癫痫药,用于治疗强直阵挛性发作、复杂的部分发作和神经外科手术相关发作。它诱导成骨细胞增殖和分化。5,5-二苯基海因用于治疗癫痫。它降低组织的过度兴奋性,可能与小脑萎缩有关。

应用

5,5-二苯基海因/苯妥英已用于苯妥英治疗。它还用于延缓或抑制中内胚层细胞迁移。

包装

5, 100 g in poly bottle

生化/生理作用

减少癫痫大发作的发生率;可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。

基本信息

经验(实验)分子式C15H12N2O2
分子量252.27
Beilstein384532
EC 号200-328-6
MDL编号MFCD00005264
PubChem化学物质编号24278370
NACRESNA.77

产品性质

质量水平100
测定≥98%
mp293-295 ℃ (lit.)
溶解性DMSO: soluble
SMILES stringO=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
InChI1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
InChI keyCXOFVDLJLONNDW-UHFFFAOYSA-N
Gene Informationhuman ... CNR1(1268), CNR2(1269), CYP2C9(1559), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Faah(29347), Scn1a(81574), Scnn1g(24768), Slc6a1(79212)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H351 - H360FD
预防措施声明P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
个人防护装备Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
8.20534Sigma-Aldrich5,5-Diphenylhydantoinfor synthesis614.31元/250 G;   咨询

产品说明

分析说明

Assay (acidimetric): ≥ 98.0 %
Melting range (lower value): ≥ 292 °C
Melting range (upper value): ≤ 295 °C
Identity (IR): passes test

基本信息

经验(实验)分子式C15H12N2O2
分子量252.27
MDL编号MFCD00005264
EC索引号200-328-6

产品性质

质量水平200
测定≥98.0% (acidimetric)
自燃温度550 ℃
效能1635 mg/kg LD50, oral (Rat)
mp292-295 ℃
堆积密度400‑450 kg/m3
储存温度2-30℃
InChI1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
InChI keyCXOFVDLJLONNDW-UHFFFAOYSA-N

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H302 - H351 - H360FD
预防措施声明P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
危险分类Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
358172Fluorochem5,5-Diphenylimidazolidine-2,4-dione>99.0%(T)1320元/25g;   14234元/500g;   咨询

基本信息

CAS Number57-41-0
MDL NumberMFCD00005264
Melting Point293-298℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H350: May cause cancer ..
防范说明 P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P281: Use personal protective equipment as required.
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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