CAS 566-27-8; 7b-hydroxycholesterol - �뵺�羺�ٷ��ַ

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货号

品牌

产品名称

规格

包装、参考价格

C912548

MACKLIN

7β-hydroxy Cholesterol

98%

420元/1mg; 1449元/5mg;

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储存：-20°C，密闭，干燥

H6891

Sigma-Aldrich

7β-Hydroxycholesterol

≥95%

1977.95元/1 MG; 5568.24元/5 MG;

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产品说明

应用

7β-羟胆固醇在人内皮细胞中可用于研究氧固醇诱导的凋亡。

包装

10 mg in poly bottle
1, 5 mg in glass bottle

生化/生理作用

7β-羟基胆固醇是一种氧固醇，即胆固醇氧化的酶促或非酶促产物。氧固醇具有细胞毒性，在单核细胞、平滑肌细胞和内皮细胞中可诱导死亡。氧固醇诱导的细胞凋亡机制可能涉及胱氨酸蛋白酶或DNA片段化。7β-羟基胆固醇的水平升高与包括动脉粥样硬化在内的心血管疾病风险提高相关。

制备说明

无论是否加热，β-羟基胆固醇在乙醇中都会生成澄清、无色至淡黄色的溶液。

基本信息

经验(实验)分子式	C₂₇H₄₆O₂
分子量	402.65
MDL编号	MFCD00058406
PubChem化学物质编号	24895774
NACRES	NA.77

产品性质

质量水平	200
测定	≥95%
形式	powder
官能团	hydroxyl
运输	ambient
储存温度	room temp
SMILES string	[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)C
InChI	1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3
InChI key	OYXZMSRRJOYLLO-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

700035P

Avanti

7β-Hydroxycholesterol

cholest-5-en-3β,7β-diol, powder

1789.68元/5 MG; 2808.58元/10 MG; 5682.45元/25 MG;

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产品说明

一般描述

7β-hydroxycholesterol (7β-OHC) is an oxysterol synthesized by the oxidation of the low-density lipoprotein (LDL). It is primarily catabolized to bile acid in the liver.

应用

7β-hydroxycholesterol has been used:

as an internal oxysterol standard in liquid chromatography–mass spectrometry (LC-MS) for the quantification of sterols associated with cholesterol biosynthesis in neurospheres post inhibitor AY9944 treatment
to reconstitute high-density lipoprotein (HDL) for anti-apoptotic studies in insulinoma cell line INS1e
as a cholesterol oxidation product standard in ultra high-performance liquid chromatography (UHPLC) coupled with high- resolution quadrupole time-of-flight (Q-TOF) mass spectrometry

生化/生理作用

7β-hydroxycholesterol (7β-OHC) favors apoptosis via caspase 8 based mitochondrial pathway. It also hinders cancer cell survival by generating reactive oxygen species(ROS). The levels of 7β-OHC are elevated in the cerebrospinal fluid of multiple sclerosis and Alzheimer′s disease (AD) patients. 7β-OHC also promotes oxiapoptophagy and demyelination. It activates mitogen-activated protein kinases and modulates intracellular Ca²⁺ homeostasis and may contribute to the disorganization of Golgi and endoplasmic reticulum membranes.

包装

5 mL Amber Glass Screw Cap Vial (700035P-25mg)
5 mL Amber Glass Screw Cap Vial (700035P-10mg)
5 mL Amber Glass Screw Cap Vial (700035P-5mg)

基本信息

经验(实验)分子式	C₂₇H₄₆O₂
分子量	402.65
NACRES	NA.25

产品性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 10 mg (700035P-10mg) pkg of 1 × 25 mg (700035P-25mg) pkg of 1 × 5 mg (700035P-5mg)
manufacturer/tradename	Avanti Polar Lipids 700035P
运输	dry ice
储存温度	−20℃
InChI	1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20?,21-,22+,23+,24+,25+,26+,27-/m1/s1
InChI key	OYXZMSRRJOYLLO-ISPKDCJXSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable