| CAS: | 56296-18-5 | |
| 分子式: | C17H18N4 | |
| 分子量: | 278.35 | |
| 中文名称: |
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| 英文名称: |
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| 用途: | DREADD agonist 21 是一种有效的人毒蕈碱乙酰胆碱 M3 受体 (hM3Dq) 激动剂 (EC50=1.7 nM)。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||||
| D878441 | MACKLIN | DREADD agonist 21 | ≥98% | 499元/100mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||||||||||||||||
| D795195 | MACKLIN | DREADD agonist 21 | 10mM in DMSO | 256元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||||
| SML2392 | Sigma-Aldrich | DREADD Agonist 21 dihydrochloride | ≥98% (HPLC) | 1055.93元/5 MG; 4256.1元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||
产品说明 生化/生理作用 Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh). 基本信息
产品性质
安全信息
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