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CAS: 56-12-2
分子式: C4H9NO2
分子量: 103.12
熔点: 197-204℃
中文名称: 
氨酪酸
γ-氨基丁酸
4-氨基丁酸
氨酷酸
英文名称: 
4-Aminobutyric acid;4-Aminobutanoic acid;GABA
.gamma.-Aminobutyric acid
4-amino-Butanoic acid
4-amino-butyric aci
4-aminobutanoic acid
4-aminobutyric acid
acide amino-4- butyrique
4-amino-butanoic aci
df 468
gaba
gamarex
gamma-amino-n-butyric acid
gamma-aminobuttersaeure
gamma-aminobutyric acid
gammalon
piperidic acid
piperidinic acid
aminobutyric acid
gamma
gamma aminobutyric acid
gammaaminobutyricacid
gamma.-Aminobutyric acid
-Aminobutanoic acid
-Aminobutyric acid
Butanoic acid,4-amino-
4-Amino-N-butyric acid
展开更多英文名
性质描述: 白色或近白色结晶性粉末。熔点203℃（分解）。极易溶于水，微溶于热乙醇，不溶于冷乙醇、乙醚和苯。熔化时分解成吡咯烷酮和水。
生产方法: 有合成法和发酵法。1.合成法由吡咯烷酮开环制得。将生石灰用蒸馏水消化成石灰乳，抽入水解反应釜，加吡咯烷酮，升温至125-130℃，反应压力保持在0.29MPa，保温反应10-14h以上。反应结束后降温至30℃出料过滤，用蒸馏水洗涤。滤液加碳酸氢铵，直至无钙离子检出，再加活性炭在80℃保温脱色30min，60℃过滤，用蒸馏水洗，洗液与滤液合并，在60℃减压浓缩至析出结晶，加入乙醇，冷却、过滤、干燥，得成品，收率为85%以上。2.发酵法 使用大肠杆菌作为菌种。发酵培养基为麸皮水解液、玉米浆、蛋白胨、硫酸镁和氯化钠等。以豆油为消沫剂，用量约为0.1%，发酵单位约为100酶单位/ml发酵液。在提炼过程中，利用大肠杆菌脱羧酶的作用，将L-谷氨酸转化为γ-氨酪酸在水溶液中能解离成阳离子的特性，采用强酸性苯乙烯系阳离子交换树脂进行离子交换，氨水洗脱，提取，再经树脂纯化，浓缩、结晶、干燥后即得成品。
用途: 医药中间体。4-氨基丁酸有降低血脂作用适用于治疗和预防各类型肝昏迷。治疗小儿麻痹症、脑溢血，并可作煤气中毒解毒剂。也用于生化研究和有机合成。
推荐供应商
货号品牌产品名称规格包装、参考价格
A861398MACKLINγ-氨基丁酸分析对照品108元/100mg;   咨询
储存：2-8ºC
状态：白色到灰白色粉末
A800350MACKLINγ-氨基丁酸99%30元/5g;   49元/25g;   64元/100g;   220元/500g;   799元/2.5kg;   2995元/10kg;   咨询
储存：室温
状态：白色到灰白色粉末或晶体
A799484MACKLINγ-氨基丁酸化妆品级41元/1g;   144元/5g;   567元/25g;   1441元/100g;   5025元/500g;   咨询
储存：室温
状态：白色到灰白色粉末或晶体
A794384MACKLINγ-氨基丁酸10mM in Water480元/1ml;   咨询
储存：-20°C
状态：液体
A0282TCI4-Aminobutyric Acid>99.0%(T)250元/25G;   450元/100G;   1350元/500G;   咨询

基本信息

纯度/分析方法>99.0%(T)
分子式/分子量C4H9NO2 = 103.12
外观与形状(20℃)固体
Reaxys-RN906818
PubChem物质ID87561936
SDBS (AIST Spectral DB)1075
Merck Index (14)430
MDL编号MFCD00008226

技术规格

AppearanceWhite powder to crystaline
Purity(Nonaqueous Titration)min. 99.0 %
Solubility in Wateralmost transparency

物性(参考值)

熔点195 ℃(dec.)

相关法规

RTECS#ES6300000
207891J&K4-Aminobutanoic acid98%81元/25G;   162元/100G;   646元/500G;   咨询

基本信息

分子式C4H9NO2
分子量103.12
熔点195
MDL编码MFCD00008226
Beilstein906818
Merck14,430
EINECS 编号200-258-6

一般描述

O-ring sealing components are used in machines required to seal the fluids or gases. Column end piece tend to trap liquid around the O-ring sealing, to avoid such a problem the upper column end piece can be redesigned.

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK2
RTECSES6300000
TSCA是
A11016Alfa Aesar4-Aminobutyric Acid97%628元/100g;   2472元/500g;   6584元/2500g;   咨询

应用
In the production of polymers, food additives, and pharmaceuticals. Acrylic acid and methacrylic acids are well known precursors of polymers.

备注
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

基本信息

MDL
MFCD00008226

EINECS
200-258-6

分子式
C4H9NO2

分子量
103.12

熔点
ca 195° dec.

灵敏度
Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in water.

Beilstein
906818

Merck
14,430

安全信息

RTECS
ES6300000

TSCA
是

C10328Alfa Aesar4-Aminobutyric Acid99+%372元/25g;   819元/100g;   3312元/500g;   9512元/2.5kg;   咨询

基本信息

Ref#
10328

MDL
8226

分子式
C4 H9 N O2

分子量
103.12

形态
White crystalline powder

R11155Alfa Aesarγ-Aminobutanoic acid (Gaba) Standard solution100ppm210元/1ml;   咨询
A2129Sigma-Aldrichγ-Aminobutyric acid≥99%218.1元/10 G;   344.81元/25 G;   1016.11元/100 G;   4035.69元/500 G;   6019.59元/1 KG;   咨询

产品说明

应用

γ-氨基丁酸(GABA)用于：

  • 制备GABA-BSA(牛血清蛋白)-GA(戊二醛)复合物，用于GABA免疫染色对照。
  • 核磁共振(MRS)高分子抑制检测。
  • GABA肠内给药，降低管腔内液体分泌

生化/生理作用

GABA(γ-氨基丁酸)是一种氨基酸，作为中枢神经系统中的抑制性神经递质，在外周组织中也可用作神经调节剂。其可与GABAA受体结合，抑制信号接收神经活性。GABAA受体能够在神经细胞细胞膜形成通道。一旦和GABA结合，受体被激活，允许带负电的分子，比如氯离子通过通道，进入细胞。这会降低细胞兴奋度。
GABA能神经元参与肌肉松弛，抗焦虑治疗，镇静和麻醉。GABA也可以影响心率和血压。
大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。

基本信息

线性分子式NH2(CH2)3COOH
分子量103.12
Beilstein906818
EC 号200-258-6
MDL编号MFCD00008226
PubChem化学物质编号24278167
NACRESNA.32

产品性质

质量水平200
测定≥99%
mp195 ℃ (dec.) (lit.)
SMILES stringNCCCC(O)=O
InChI1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChI keyBTCSSZJGUNDROE-UHFFFAOYSA-N
Gene Informationhuman ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Gabbr1(81657), Gabra1(29705), Gabra2(29706), Gabrb2(25451), Gabrg2(29709), Slc6a1(79212), Slc6a12(50676)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
03835Supelcoγ-Aminobutyric acidanalytical standard1194.79元/250MG;   咨询

产品说明

一般描述

γ-氨基丁酸是一种主要的抑制性神经递质，存在于小脑、下丘脑、丘脑和海马。通过谷氨酸脱羧酶 (GAD) 催化的 L -谷氨酸脱羧形成。

生化/生理作用

大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。

基本信息

线性分子式NH2(CH2)3COOH
分子量103.12
Beilstein906818
EC 号200-258-6
MDL编号MFCD00008226
PubChem化学物质编号329747825
NACRESNA.24

产品性质

质量水平100
等级analytical standard
测定≥97.0% (HPLC)
保质期limited shelf life, expiry date on the label
analyte chemical class(es)amino acids, peptides, proteins
technique(s)HPLC: suitable
杂质≤1.0% water
mp195 ℃ (dec.) (lit.)
application(s)cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
格式neat
SMILES stringNCCCC(O)=O
InChI1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChI keyBTCSSZJGUNDROE-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
8.00302Sigma-Aldrich4-Aminobutyric Acidfor synthesis381.21元/100 G;   26670元/25 KG;   咨询

产品说明

分析说明

Assay (HClO₄): ≥ 98.0 %
Identity (IR): passes test

基本信息

经验(实验)分子式C4H9NO2
分子量103.12
MDL编号MFCD00008226
EC索引号200-258-6

产品性质

质量水平200
mp200-202 ℃
储存温度2-30℃
InChI1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChI keyBTCSSZJGUNDROE-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
A5835Sigma-Aldrichγ-Aminobutyric acidBioXtra, ≥99%710元/10 G;   1483.69元/25 G;   2979.75元/100 G;   咨询

产品说明

一般描述

γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean, germinated rice, and in some fermented foods.

应用

γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats. It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.

包装

10 mg in autosample vial

生化/生理作用

γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions. It is crucial for the normal central nervous system (CNS) functioning. A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects. GABA might show beneficial effects on stress and sleep in humans. γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.
大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。

基本信息

线性分子式NH2(CH2)3COOH
分子量103.12
Beilstein906818
EC 号200-258-6
MDL编号MFCD00008226
PubChem化学物质编号24891025
NACRESNA.26

产品性质

质量水平200
产品线BioXtra
测定≥99%
形式powder
technique(s)ligand binding assay: suitable
杂质<0.0005% Phosphorus (P)
<0.1% Insoluble matter
灼烧残渣<0.1%
颜色 white
mp195 ℃ (dec.) (lit.)
溶解性H2O: 0.5 M at 20 ℃, clear, colorless
痕量阴离子chloride (Cl-): <0.04%
sulfate (SO42-): <0.05%
痕量阳离子Al: <5 mg/kg
Ca: <20 mg/kg
Cu: <5 mg/kg
Fe: <5 mg/kg
K: <50 mg/kg
Mg: <50 mg/kg
NH4+: <500 mg/kg
Na: <70 mg/kg
Pb: <10 mg/kg
Zn: <5 mg/kg
SMILES stringNCCCC(O)=O
InChI1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChI keyBTCSSZJGUNDROE-UHFFFAOYSA-N
Gene Informationhuman ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Gabra1(29705), Gabra2(29706), Olr1750(294204), Slc6a1(79212), Slc6a12(50676)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
Y0001404Vigabatrin impurity DEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。

包装

Unit quantity: 50 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

线性分子式NH2(CH2)3COOH
分子量103.12
Beilstein906818
MDL编号MFCD00008226
PubChem化学物质编号329831405
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
mp195 ℃ (dec.) (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringNCCCC(O)=O
InChI1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChI keyBTCSSZJGUNDROE-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
43811Supelcoγ-Aminobutyric acidcertified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland1898.19元/50 mg;   咨询

产品说明

一般描述

该认证标准物质(CRM)根据ISO/IEC 17025和ISO 17034生产和认证。该CRM可追溯到来自NMI的原材料，如 NIST或NMIJ。
证书上给出了定量核磁共振法认证的内容，包括不确定性和失效日期。
请访问http://www.sigma-aldrich.com下载您的证书。

生化/生理作用

大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。

法律信息

TraceCERT is a registered trademark of sigma-aldrich Co. LLC

基本信息

线性分子式NH2(CH2)3COOH
分子量103.12
Beilstein906818
EC 号200-258-6
MDL编号MFCD00008226
PubChem化学物质编号329756408

产品性质

质量水平300
等级certified reference material
TraceCERT®
产品线TraceCERT®
保质期limited shelf life, expiry date on the label
analyte chemical class(es)amino acids, peptides, proteins
储存条件under inert gas
technique(s)gas chromatography (GC): suitable
mp195 ℃ (dec.) (lit.)
application(s)food and beverages
格式neat
储存温度2-8℃
SMILES stringNCCCC(O)=O
InChI1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChI keyBTCSSZJGUNDROE-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
PHL83415γ-Aminobutyric acidphyproof® Reference Substance3048.57元/100 MG;   咨询

产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化/生理作用

大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

线性分子式NH2(CH2)3COOH
分子量103.12
Beilstein906818
MDL编号MFCD00008226

产品性质

等级primary reference standard
产品线phyproof® Reference Substance
测定≥98.0% (HPLC)
形式crystals
manufacturer/tradenamePhytoLab
mp195 ℃ (dec.) (lit.)
SMILES stringNCCCC(O)=O
InChI1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChI keyBTCSSZJGUNDROE-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1020023USPγ-Aminobutyric acidUnited States Pharmacopeia (USP) Reference Standard3572.92元/50 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

线性分子式NH2(CH2)3COOH
分子量103.12
Beilstein906818
MDL编号MFCD00008226
PubChem化学物质编号329748981

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp195 ℃ (dec.) (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringNCCCC(O)=O
InChI1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChI keyBTCSSZJGUNDROE-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
317856Fluorochem4-Aminobutyric Acid97%220元/1g;   264元/25g;   396元/100g;   792元/250g;   2112元/1kg;   咨询

基本信息

CAS Number56-12-2
MDL NumberMFCD00008226
Melting Point197-204℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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