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CAS: 55779-48-1
分子式: C26H21N3O3
分子量: 423.4632
沸点: 641.4℃ at 760 mmHg
英文名称: 
coelenterazine
推荐供应商
货号品牌产品名称规格包装、参考价格
C873581MACKLIN天然腔肠素95%956元/1mg;   2125元/5mg;   7355元/25mg;   14710元/100mg;   咨询
储存:-20℃
状态:棕色黄色固体
C766688MACKLIN天然腔肠素10mM in DMSO999元/1ml;   咨询
储存:-20℃, 干燥, 避光
181289J&KCoelenterazine95%1881元/1MG;   咨询

基本信息

分子式C26H21N3O3
分子量423.46
MDL编码MFCD00467176
存储条件Freezer -20℃

安全信息

防范说明P262
WGK3
C2230Sigma-AldrichCoelenterazine, nativesolid2397.92元/50 μG;   咨询

产品说明

一般描述

腔肠素是萤光素分子,可被多种萤光素酶利用,如 海肾属刺虾属绿叶水母中存在的荧光素酶。

应用

天然腔肠素用于:

  • 水母发光蛋白测定
  • 在 COS-7 细胞中使用水母发光蛋白测量离子霉素或 PMA 诱导的细胞内钙离子浓度
  • 在生物发光成像中分析病毒依赖性荧光素酶活性的存在

生化/生理作用

当 Ca 2 + 与复合物结合时,水母发光蛋白复合物的发光基团被氧气氧化并在 465 nm 处发光;用于测量细胞内 Ca 2 + 浓度,灵敏度高,动态范围大。

注意

避免光照

基本信息

经验(实验)分子式C26H21N3O3
分子量423.46
MDL编号MFCD00467176
PubChem化学物质编号24892477
NACRESNA.32

产品性质

测定≥95% (TLC)
质量水平200
形式solid
溶解性methanol and ethanol: soluble
储存温度−20℃
SMILES stringOc1ccc(CC2=NC3=C(Cc4ccccc4)NC(=CN3C2=O)c5ccc(O)cc5)cc1
InChI1S/C26H21N3O3/c30-20-10-6-18(7-11-20)15-23-26(32)29-16-24(19-8-12-21(31)13-9-19)27-22(25(29)28-23)14-17-4-2-1-3-5-17/h1-13,16,27,30-31H,14-15H2
InChI keyYHIPILPTUVMWQT-UHFFFAOYSA-N

安全信息

危险声明H413
预防措施声明P273 - P501
危险分类Aquatic Chronic 4
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)
233900Sigma-AldrichCoelenterazine-CAS 122384-88-7-CalbiochemA cell-permeable aequorin luminophore that acts as a very sensitive and specific chemiluminescence probe of the superoxide anion.3897.31元/250 μG;   咨询

产品说明

一般描述

Coelenterazine (CTZ), a small prosthetic group, is a luciferin or light-producing compound present in luminous marine organisms. The imidazopyrazinone ring in CTZ is responsible for its luminous properties. This chemiluminescent dye is soluble in methanol and poorly soluble in water. CTZ can be oxidized with the help of bovine serum albumin (BSA) and several other luciferases.

应用

Coelenterazine - CAS 122384-88-7 – Calbiochem may be used:

  • to determine superoxide production
  • to determine free radical production
  • in cell suspension buffer for in vivo reconstitution of aequorin

包装

250 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Coelenterazine (CTZ) is a cell-permeable aequorin luminophore that acts as a very sensitive and specific chemiluminescence probe of the superoxide anion. It can also be used for detecting changes in intracellular Ca2+ in cells that have been transfected with apoaequorin cDNA. CTZ functions as a powerful antioxidant. It serves as a substrate for multidrug resistance protein 1 (MDR1) P-glycoprotein (ATP-binding cassette sub-family B member 1 (ABCB1)/Pgp) and can bind with apoaequorin to form the active aequorin complex. It can be mainly used to quantify the formation of superoxide in neutrophils.

警告

Toxicity: Standard Handling (A)

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C26H21N3O3
分子量423.46
MDL编号MFCD00467176

产品性质

质量水平100
测定≥90% (TLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 brown
溶解性methanol: 1 mg/mL
ethanol: soluble
运输ambient
储存温度−20℃
InChI1S/C26H21N3O3/c30-20-10-6-18(7-11-20)15-23-26(32)29-16-24(19-8-12-21(31)13-9-19)27-22(25(29)28-23)14-17-4-2-1-3-5-17/h1-13,16,27,30-31H,14-15H2
InChI keyYHIPILPTUVMWQT-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
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