CAS 550-24-3; 2,5-dihydroxy-3-undecyl-p-benzoquinon

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货号

品牌

产品名称

规格

包装、参考价格

E860566

MACKLIN

恩贝酸

分析对照品,98%

385元/10mg;

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储存：-20°C
状态：固体

445118

J&K

Embelin

98%

1825.9元/20MG;

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基本信息

分子式	C₁₇H₂₆O₄
分子量	294.39
MDL编码	MFCD00016369
EINECS 编号	208-979-8
存储条件	Store at 2-8℃

安全信息

WGK

E1406

Sigma-Aldrich

Embelin

≥98% (HPLC), powder

1402.36元/10 MG; 4883.16元/50 MG;

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产品说明

一般描述

恩贝酸是一种天然的苯醌衍生物，最早从白花酸滕果植物中提取。它在结构上类似于泛醌。

应用

使用恩贝酸：

研究其对活化T细胞(NFATc1)荧光素酶活性的核因子kB配体(RANKL)诱导的核因子的受体激活剂的影响
研究其在介导帕金森病(PD)机制中的作用′
治疗全鼠胚胎，以确定其对X连锁抑制细胞凋亡蛋白(XIAP)活性的影响

包装

10 mg in glass bottle

生化/生理作用

恩贝酸具有抗氧化、线粒体解耦联和抗生育特性。它还具有抗糖尿病、抗惊厥、抗焦虑和抗微生物活性等作用。恩贝酸是一种有效的神经保护剂，也可作为脑卒中的辅助治疗。
恩贝酸(Embelin)是XIAP(X连锁凋亡抑制蛋白)的抑制剂；体内抗肿瘤和抗炎活性。

基本信息

经验(实验)分子式	C₁₇H₂₆O₄
分子量	294.39
EC 号	208-979-8
MDL编号	MFCD00016369
PubChem化学物质编号	24724473
NACRES	NA.77

产品性质

质量水平	200
测定	≥98% (HPLC)
形式	powder
溶解性	DMSO: >10 mg/mL H₂O: insoluble
作用机制	DNA synthesis \| interferes
抗生素抗菌谱	Gram-negative bacteria Gram-positive bacteria parasites
SMILES string	CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
InChI	1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
InChI key	IRSFLDGTOHBADP-UHFFFAOYSA-N
Gene Information	human ... XIAP(331)

安全信息

象形图
警示用语：	Warning
危险声明	H361f
预防措施声明	P201 - P308 + P313
危险分类	Repr. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

PHL89654

Embelin

phyproof^® Reference Substance

3048.57元/100 MG;

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产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化/生理作用

恩贝酸(Embelin)是XIAP(X连锁凋亡抑制蛋白)的抑制剂；体内抗肿瘤和抗炎活性。

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

经验(实验)分子式	C₁₇H₂₆O₄
分子量	294.39
MDL编号	MFCD00016369

产品性质

等级	primary reference standard
产品线	phyproof^® Reference Substance
测定	≥90.0% (HPLC)
manufacturer/tradename	PhytoLab
application(s)	food and beverages
格式	neat
SMILES string	CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
InChI	1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
InChI key	IRSFLDGTOHBADP-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H361f
预防措施声明	P201 - P308 + P313
危险分类	Repr. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

178493

Sigma-Aldrich

Apoptosis Activator III, Embelin-CAS 550-24-3-Calbiochem

The Apoptosis Activator III, Embelin, also referenced under CAS 550-24-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

1700.13元/10 MG;

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产品说明

一般描述

A cell-permeable, benzoquinone compound that exhibits anti-tumor properties. Shown to specifically antagonize X-linked inhibitor of apoptosis- (XIAP) mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC₅₀ = 4.1 µM in a competitive binding assay using Smac peptide). Also selectively induces caspase-9-mediated apoptosis in prostate cancer cells expressing high levels of XIAP (IC₅₀ = 3.7 µM for PC-3 cells and 5.7 µM for LnCap cells), while exhibiting lesser effects toward cells with low levels of XIAP (IC₅₀ = 19.3 µM for WI-38 cells and 20.1 µM for PrEC cells). Reported to sensitize XIAP-overexpressing Jurkat cells to Etoposide- (Cat. No. 341245) induced apoptosis. A non-competitive PCAF (p300/CBP associated factor)-specific lysine acetyltransferase (KAT) inhibitor (IC₅₀ = 7.2 µM).
A cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP (X-linked inhibitor of apoptosis)-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC₅₀ = 4.1 µM in a competitive binding assay with Smac peptide). Selectively induces caspase-9-mediated apoptosis in prostate cancer cells with high levels of XIAP (IC₅₀ = 3.7 and 5.7 µM for PC-3 and LnCap, respectively), while exhibiting much less effect towards cells with low level XIAP (IC₅₀ = 19.3 and 20.1 µM for WI-38 and PrEC, respectively). Also shown to sensitize XIAP overexpressing Jurkat cells to Etoposide -induced apoptosis. A non-competitive PCAF (p300/CBP associated factor)-specific lysine acetyltransferase (KAT) inhibitor (IC₅₀ = 7.2 µM).

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
BIR3
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 4.1 µM in antagonizing XIAP (X-linked inhibitor of apoptosis)-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 in a competitive binding assay with Smac peptide

警告

Toxicity: Standard Handling (A)

分析说明

Single spot by TLC

其他说明

Modak, R., et al. 2013. ACS Chem. Biol.8, In press.
Nikolovska-Coleska, Z., et al. 2004. J. Med. Chem.47, 2430.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₇H₂₆O₄
分子量	294.39
MDL编号	MFCD00016369

产品性质

质量水平	100
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	orange
溶解性	DMSO: 10 mg/mL methanol: 5 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
InChI key	IRSFLDGTOHBADP-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H361f
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Repr. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

032344

Fluorochem

2,5-Dihydroxy-3-undecyl-[1,4]benzoquinone

97%

19294元/1g;

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基本信息

CAS Number	550-24-3
MDL Number	MFCD00016369