CAS 54573-75-0; 7,10(19),22-tetraene-1,3-diol, (1-alpha,3-beta,5z,7e,22e)-10-secoergosta-5

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货号

品牌

产品名称

规格

包装、参考价格

D797006

MACKLIN

度骨化醇

10mM in DMSO

899元/1ml;

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储存：-20°C

D808072

MACKLIN

度骨化醇

98%

254元/1mg; 542元/5mg;

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储存：-20°C
状态：白色到灰白色粉末或固体或块状

D5526

TCI

Doxercalciferol

>98.0%(HPLC)

690元/5MG; 2390元/25MG;

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基本信息

纯度/分析方法	>98.0%(HPLC)
分子式/分子量	C₂₈H₄₄O₂ = 412.66
外观与形状(20℃)	固体
储存温度	-20℃
应避免的情况	加热
Reaxys-RN	4716774
Merck Index (14)	3436
MDL编号	MFCD00871065

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Specific rotation [a]20/D	+46.0 to +50.0 deg(C=0.5,EtOH)
Elemental analysis(Carbon)	79.90 to 83.10 %

物性(参考值)

熔点	140 ℃
最大吸收波长	265(EtOH) nm

安全信息

图形或危害标志
信号词	危险
危险性说明	H300 : 吞咽致命。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P270 : 使用本产品时不要进食、饮水或吸烟。 P264 : 作业后彻底清洗皮肤。 P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。 P405 : 存放处须加锁。

相关法规

RTECS#

VS2950000

运输信息

UN编号	UN2811
类别	6.1
包装类别	I
监管条件代码(*)

483486

J&K

Doxercalciferol

98%

417元/1MG; 855元/5MG;

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基本信息

分子式	C₂₈H₄₄O₂
分子量	412.65
熔点	140
MDL编码	MFCD01076571
存储条件	Freezer -20℃

生化/生理作用

Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4.Doxercalciferol is a vitamin D2 analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D2. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR.

安全信息

图形或危害标志
提示语	Danger
危险说明	H300
防范说明	P501 P270 P264 P301+P310+P330 P405
UN号码	2811
危险分类	6.1
包装等级	I
RTECS	VS2950000

D0196

Sigma-Aldrich

Doxercalciferol

≥98% (HPLC), solubility: >10 mg/mL in DMSO

1214.38元/1 MG; 4845.94元/5 MG;

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产品说明

包装

1, 5 mg in glass bottle

生化/生理作用

Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4.
Doxercalciferol is a vitamin D₂ analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D₂. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR.

基本信息

经验(实验)分子式	C₂₈H₄₄O₂
分子量	412.65
MDL编号	MFCD00871065
PubChem化学物质编号	329798592
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
溶解性	DMSO: >10 mg/mL
运输	wet ice
储存温度	−20℃
SMILES string	CC(C)[C@@H](C)\C=C\[C@@H](C)[C@H]1CC[C@H]2C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C
InChI	1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
InChI key	HKXBNHCUPKIYDM-CGMHZMFXSA-N
Gene Information	human ... VDR(7421)

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P264 - P301 + P310
危险分类	Acute Tox. 1 Oral
储存分类代码	6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

1225601

USP

Doxercalciferol

United States Pharmacopeia (USP) Reference Standard

12401.6元/2 X 20 MG;

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产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4.
Doxercalciferol is a vitamin D₂ analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D₂. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式	C₂₈H₄₄O₂
分子量	412.65
MDL编号	MFCD00871065
PubChem化学物质编号	329749675
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	USP
application(s)	pharmaceutical (small molecule)
格式	neat
SMILES string	CC(C)[C@@H](C)\C=C\[C@@H](C)[C@H]1CC[C@H]2C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C
InChI	1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
InChI key	HKXBNHCUPKIYDM-CGMHZMFXSA-N
Gene Information	human ... VDR(7421)

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 1 Oral
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable