CAS 54-25-1; 4h)-dione, 2-beta-d-ribofuranosyl-as-triazine-5(2h

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CAS:

54-25-1

分子式:

C8H11N3O6

分子量:

245.19

熔点:

157-159℃

英文名称:

4h)-dione, 2-beta-d-ribofuranosyl-as-triazine-5(2h

4-triazine-3,5(2h,4h)-dione, 2-beta-d-ribofuranosyl-2

2-beta-d-ribofuranosyl-1,2,4-triazin-3,5(2h,4h)-dion

2-beta-d-ribofuranosyl-1,2,4-triazine-3,5(2h,4h)-dione

2-beta-d-ribofuranosyl-as-triazine-3,5(2h,4h)-dione

3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine riboside

6-azauracil 1-riboside

6-azauracil-beta-d-riboside

6-azauracilribosid

6-azauracilriboside

6-azauridine

6-azur

6-azuridine

azauridine

azur

nsc 32074

ribo-azuracil

riboazauracil

展开更多英文名

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

A871285

MACKLIN

6-氮杂尿苷

99%

80元/100mg; 237元/500mg;

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储存：2-8°C
状态：白色到几乎白色粉末到晶体

A890170

MACKLIN

6-氮杂尿苷

95%

60元/100mg;

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储存：2-8°C
状态：白色到几乎白色粉末到晶体

A0559

TCI

6-Azauridine

>99.0%(HPLC)

320元/10MG;

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基本信息

纯度/分析方法	>99.0%(HPLC)
分子式/分子量	C₈H₁₁N₃O₆ = 245.19
外观与形状(20℃)	固体
储存温度	0-10℃
应避免的情况	加热
Reaxys-RN	32281
PubChem物质ID	87562154
SDBS (AIST Spectral DB)	6208
Merck Index (14)	904
MDL编号	MFCD00006472

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 99.0 area%
Melting point	158.0 to 161.0 ℃
Specific rotation [a]20/D	-130 to -137 deg(C=1、Pyridine)

物性(参考值)

熔点	158 ℃
比旋光度 [α]D	-134° (C=1,Pyridine)

相关法规

RTECS#

XY8575000

A1882

Sigma-Aldrich

6-Azauridine

1043.22元/1 G; 3112.14元/5 G;

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产品说明

一般描述

6-Azauridine is a pyrimidine nucleoside analog.

应用

6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP and it is used in antiviral studies.
6-Azauridine has been used:

in uridine monophosphate synthase (UMPS) activity assay
as an antiviral agent to study its inhibition effect and cytotoxic potential on foot and mouth disease virus
to screen for anticryptosporidial activity
in the pretreatment of HeLa cells to study its effect on inhibition of cellular uridine synthesis before and during chase with 5-bromouridine 5′-triphosphate (BrUTP)
as a reference compound for comparing the antiviral activity and cytotoxic activity against viral host cell lines

包装

1, 5 g in poly bottle

生化/生理作用

6-azauridine is a prodrug, upon conversion to 6-aza-UMP, inhibits uridine monophosphate synthase (UMPS). It is a broad spectrum anti-metabolite. It interferes with pyrimidine biosynthesis and affects the cellular nucleic acid levels. It is considered as a antineoplastic metabolite. It inhibits RNA viruses like chikungunya virus, semliki forest virus, and human coronavirus. It significantly inhibits the growth of Cryptosporidium parasites.

基本信息

经验(实验)分子式	C₈H₁₁N₃O₆
分子量	245.19
EC 号	200-199-6
MDL编号	MFCD00006472
PubChem化学物质编号	24890597
NACRES	NA.51

产品性质

测定	≥99% (TLC)
质量水平	200
形式	powder
mp	157-159 ℃ (lit.)
溶解性	water: 50 mg/mL, clear, colorless
储存温度	2-8℃
SMILES string	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2N=CC(=O)NC2=O
InChI	1S/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)/t3-,5-,6-,7-/m1/s1
InChI key	WYXSYVWAUAUWLD-SHUUEZRQSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H312 + H332 - H351
预防措施声明	P201 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
危险分类	Acute Tox. 4 Oral - Carc. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

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