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CAS: 5370-01-4
分子式: C11H18ClNO
分子量: 215.72
熔点: 200-203℃
中文名称: 
盐酸美西津
盐酸美西律
英文名称: 
1-methyl-2-(2,6-xylyloxy)-ethylamin hydrochloride
1-(2,6-dimethylphenoxy)-2-aminopropane hydrochloride
1-(2,6-dimethylphenoxy)-2-propanamine hydrochloride
1-methyl-2-(2,6-xylyloxy)-ethylamine hydrochloride
1-(2,6-dimethylphenoxy)-2-propanamin hydrochloride
ko 1173
koe 1173 hydrochloride
mexitil
1-(2,6-dimethylphenoxy)-2-propanamine hydrochlori
用途: 抗心律失常药。
推荐供应商
货号品牌产品名称规格包装、参考价格
D838212MACKLIN1-(2,6-二甲基苯氧基)-2-丙胺 盐酸盐, 97%97 %89元/5g;   235元/25g;   咨询
储存:室温
状态:白色到几乎白色粉末到晶体
D793377MACKLIN1-(2, 6-二甲基苯氧基)-2-丙胺 盐酸盐, 97%10mM in DMSO311元/1ml;   咨询
储存:-20°C
M2040TCIMexiletine Hydrochloride>98.0%(HPLC)(N)345元/1G;   1015元/5G;   咨询

基本信息

纯度/分析方法>98.0%(HPLC)(N)
分子式/分子量C11H17NO・HCl = 215.72
外观与形状(20℃)固体
Reaxys-RN4209895
PubChem物质ID87560985
SDBS (AIST Spectral DB)52401
Merck Index (14)6169
MDL编号MFCD00216024

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(with Total Nitrogen)min. 98.0 %
Melting point200.0 to 205.0 ℃

物性(参考值)

熔点202 ℃
最大吸收波长272(MeOH) nm
水溶性完全溶解
溶解性(易溶于)

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#KR9310000
C37291Alfa AesarMexiletine Hydrochloride514元/5g;   1440元/25g;   4685元/100g;   咨询

基本信息

Ref#
37291

分子式
C11H17NO.HCl

分子量
123.89

GHS危害和防范说明

GHS符号

Hazard Statements
H302 H315 H319

Precautionary Statements
P301+P330+P331 P312 P302+P352 P337+P313 P280

M2727Sigma-AldrichMexiletine Hydrochloridepowder1468.97元/25 G;   3943.82元/100 G;   咨询

产品说明

一般描述

美西律是一种IB类抗心律失常药,是利多卡因的类似物。它的半衰期为10-12小时,在肝脏中代谢,通过还原、氧化或结合反应消除。

应用

盐酸美西律可作为钠离子通道阻滞剂用于:

  • 中国仓鼠卵细胞
  • 人胚胎肾 (HEK) 细胞,用于全细胞膜片钳研究
  • 表达Nav1.7蛋白的HEK细胞的电生理研究

生化/生理作用

美西律是一种有效的钠离子通道阻滞药。它是一种抗心律失常药,在头疼和神经性疼痛中可作为辅助药物美西律用于治疗钠离子通道病的肌强直症状,并缩短心脏动作电位的去极化时程,但不会对心房不应期造成影响。它对钠通道的抑制作用可有效治疗钾加重性肌强直。

特点和优势

该化合物由 Boehringer Ingelheim 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单,请单击此处。

基本信息

经验(实验)分子式C11H17NO · HCl
分子量215.72
EC 号250-825-7
MDL编号MFCD00216024
PubChem化学物质编号24278542
NACRESNA.77

产品性质

质量水平200
测定≥98% (GC)
形式powder
颜色 white to off-white
溶解性methanol: 50 mg/mL
创始人Boehringer Ingelheim
储存温度2-8℃
SMILES stringCl[H].CC(N)COc1c(C)cccc1C
InChI1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
InChI keyNFEIBWMZVIVJLQ-UHFFFAOYSA-N
Gene Informationhuman ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
M1860000Mexiletine HydrochlorideEuropean Pharmacopoeia (EP) Reference Standard1259.15元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C11H17NO · HCl
分子量215.72
MDL编号MFCD00216024
PubChem化学物质编号329817898
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCl[H].CC(N)COc1c(C)cccc1C
InChI1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
InChI keyNFEIBWMZVIVJLQ-UHFFFAOYSA-N
Gene Informationhuman ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
1443250USPMexiletine HydrochlorideUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C11H17NO · HCl
分子量215.72
MDL编号MFCD00216024
PubChem化学物质编号329750463
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCl[H].CC(N)COc1c(C)cccc1C
InChI1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
InChI keyNFEIBWMZVIVJLQ-UHFFFAOYSA-N
Gene Informationhuman ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P301 + P312 + P330
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
333722FluorochemMEXILETINE HCL95%374元/1g;   1100元/5g;   5038元/25g;   12562元/100g;   咨询

基本信息

CAS Number5370-01-4
MDL NumberMFCD00216024

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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