CAS 53598-01-9; n<sup>g</sup>-羟基-<sc>l</sc>-精氨酸乙酸盐; n<sup>g</sup>-hydroxy-<sc>l</sc>-arginine acetate salt

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货号

品牌

产品名称

规格

包装、参考价格

N921688

MACKLIN

NG-羟基-L-精氨酸乙酸盐

98% (TLC)

1169元/1mg;

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储存：2-8°C
状态：白色到灰白色粉末

H7278

Sigma-Aldrich

N^G-Hydroxy-L-arginine acetate salt

1333.25元/1 MG; 4625.55元/5 MG;

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产品说明

包装

1, 5 mg in glass bottle

生化/生理作用

通过NO合酶将精氨酸转化为NO和瓜氨酸过程中的中间体。
NG-羟基-L-精氨酸是精氨酸酶的生理抑制剂。

基本信息

经验(实验)分子式	C₆H₁₄N₄O₃ · C₂H₄O₂
分子量	250.25
MDL编号	MFCD00216150
PubChem化学物质编号	24278471
NACRES	NA.77

产品性质

测定	≥98% (TLC)
质量水平	200
形式	powder
mp	204 ℃
溶解性	acetic acid: 10 mg/mL, clear, colorless to faintly yellow
储存温度	2-8℃
SMILES string	CC(O)=O.N[C@@H](CCCNC(=N)NO)C(O)=O
InChI	1S/C6H14N4O3.C2H4O2/c7-4(5(11)12)2-1-3-9-6(8)10-13;1-2(3)4/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10);1H3,(H,3,4)/t4-;/m0./s1
InChI key	VYMCYRPQICLHKC-WCCKRBBISA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

399250

Sigma-Aldrich

N^G-Hydroxy-L-arginine, Monoacetate Salt-CAS 53598-01-9-Calbiochem

Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.

2427.06元/5 MG;

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产品说明

一般描述

Cell-permeable. A key intermediate product in the biosynthesis of nitric oxide from arginine by constitutive nitric oxide synthase (cNOS). Formed by the NADPH-dependent hydroxylation of L-arginine. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450, providing an alternative biosynthetic route for the production of nitric oxide. A potent inhibitor of liver and macrophage arginase (K_i = 150 µM).
Cell permeable. A key intermediate in the biosynthesis of nitric oxide by constitutive nitric oxide synthase (cNOS). NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system. A potent inhibitor of liver and macrophage arginase (K_i = 150 µM).

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
liver and macrophage arginase

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun.193, 963.
Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun.187, 880.
Stuehr, D.J., et al. 1991. J. Biol. Chem.266, 6259.
Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun.176, 528.
Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA88, 11172.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₆H₁₄N₄O₃ · xC₂H₄O₂
分子量	190.20 (free base basis)
MDL编号	MFCD00216150

产品性质

质量水平	100
测定	≥98% (elemental analysis)
形式	solid
效能	150 μM K_i
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	water: 1 mg/mL
运输	ambient
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable