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CAS: 53501-41-0
分子式: C14H10ClN3O4S
分子量: 351.8
英文名称: 
pit-1
n-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide
用途: PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding with an IC50 value of 31 μM.
推荐供应商
货号品牌产品名称规格包装、参考价格
P911359MACKLINPIT-198%718元/5mg;   咨询
储存:-20°C,密闭,干燥
SML0122Sigma-AldrichPit-1≥98% (HPLC)897.48元/5 MG;   3631.56元/25 MG;   咨询

产品说明

应用

Pit-1 may be used in PIP3-mediated cell signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

Pit-1 is a small-molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonist that binds and blocks the pleckstrin domain. It shows inhibitory effects on tumor angiogenesis and metastasis by interfering with the activation of Akt.
PIT-1 is a PIP3-PH domain antagonist
PIT-1 represents a new class of molecules referred to as PITenins, or PITs. PITs inhibit the binding of PIP3 to the PH domains of several target proteins, including Akt and PDK1, without affecting interactions against PIP2-selective PH domains. PIT-1 inhibits PI3K-PKD-1-Akt dependent phosphorylation in cell based assays, including the phosphorylation of Akt-1, 2 and 3.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C14H10ClN3O4S
分子量351.76
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to tan
溶解性DMSO: ≥14 mg/mL
储存温度2-8℃

安全信息

象形图GHS07GHS09
警示用语:Warning
危险声明H302 - H400
预防措施声明P273 - P301 + P312 + P330
危险分类Acute Tox. 4 Oral - Aquatic Acute 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
CAS号首数字顺序排列: 1 2 3 4 5 6 7 8 9
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